{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:33:12Z","timestamp":1792114392241,"version":"4.4.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100011684","name":"Crohn\u2019s & Colitis Foundation","doi-asserted-by":"crossref","award":["828830"],"award-info":[{"award-number":["828830"]}],"id":[{"id":"10.13039\/100011684","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK134814"],"award-info":[{"award-number":["K23DK134814"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Buhlmann Diagnostics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Poor sleep is common in Crohn\u2019s disease (CD), prospectively predicts worse disease course, and is often attributable to insomnia. Cognitive behavioral therapy for insomnia (CBT-I) is the recommended treatment for chronic insomnia disorder. CBT-I improves sleep and may improve pain intensity, pain interference, and inflammation. We sought to investigate whether CBT-I impacts these factors in patients with active CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We recruited patients with insomnia and mild-to-moderate CD symptoms from an inflammatory bowel disease center. Exclusion criteria were other sleep disorders, significant psychiatric concerns, and presence of other common influences on sleep. Participants completed baseline assessments of sleep, pain, and inflammation then were randomized to receive CBT-I immediately, or wait 12\u2009weeks and then repeat the baseline assessment and complete CBT-I. Similar assessments occurred immediately post\u2013CBT-I and 1 month later. CBT-I included sleep restriction, stimulus control, sleep hygiene, arousal reduction, and cognitive therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 26 participants completed the study. In group \u00d7 time analyses, CBT-I led to greater reductions in insomnia severity (P\u2009&amp;lt;\u2009.001) and wake after sleep onset (P\u2009=\u2009.02) than waitlist. In pre- to post-treatment analyses, participants reported significant improvements in subjective measures of sleep continuity, CD symptom severity, pain intensity, and pain interference. C-reactive protein trended toward improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study provides preliminary evidence of efficacy of CBT-I in people with CD. CBT-I improved self-reported sleep and may improve pain and CD symptoms. The results highlight the importance of addressing sleep concerns in inflammatory bowel disease, particularly in people with persistent pain or fatigue. Future trials powered to detect changes in pain and inflammation are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf210","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T11:55:54Z","timestamp":1755690954000},"page":"106-117","source":"Crossref","is-referenced-by-count":3,"title":["Cognitive Behavioral Therapy for Insomnia May Improve Sleep and Pain in Crohn\u2019s Disease: A Waitlist Control Pilot Trial"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6498-3729","authenticated-orcid":false,"given":"Jessica K","family":"Salwen-Deremer","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Dartmouth Hitchcock Medical Center , Lebanon, NH,","place":["United States"]},{"name":"Section of Gastroenterology and Hepatology, Center for Digestive Health, Dartmouth Hitchcock Medical Center , Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J","family":"Westvold","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale School of Medicine , New Haven, CT,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Aschbrenner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dartmouth Hitchcock Medical Center , Lebanon, NH,","place":["United States"]},{"name":"Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth , Hanover, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Psychology and Behavioral Sciences, Johns Hopkins School of Medicine , Baltimore, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2240-6605","authenticated-orcid":false,"given":"Corey A","family":"Siegel","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology, Center for Digestive Health, Dartmouth Hitchcock Medical Center , Lebanon, NH,","place":["United States"]},{"name":"Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth , Hanover, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"2026010301015732400_izaf210-B1","doi-asserted-by":"crossref","first-page":"zpac025","DOI":"10.1093\/sleepadvances\/zpac025","article-title":"A systematic review and meta-analysis of the prevalence of poor sleep in inflammatory bowel disease","volume":"3","author":"Barnes","year":"2022","journal-title":"Sleep Adv"},{"key":"2026010301015732400_izaf210-B2","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.cgh.2013.01.021","article-title":"Sleep disturbance and risk of active disease in patients with Crohn\u2019s disease and ulcerative colitis","volume":"11","author":"Ananthakrishnan","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026010301015732400_izaf210-B3","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1186\/s40064-016-3408-6","article-title":"Sleep disturbances in Japanese patients with inflammatory bowel disease and their impact on disease flare","volume":"5","author":"Uemura","year":"2016","journal-title":"Springerplus"},{"key":"2026010301015732400_izaf210-B4","first-page":"1251","article-title":"Poor sleep quality in Crohn\u2019s disease is associated with disease activity and risk for hospitalization or surgery","volume":"26","author":"Sofia","year":"2020","journal-title":"Inflamm Bowel Dis"},{"key":"2026010301015732400_izaf210-B5","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1007\/s10620-021-07176-y","article-title":"Poor sleep in inflammatory bowel disease is reflective of distinct sleep disorders","volume":"67","author":"Salwen-Deremer","year":"2022","journal-title":"Dig Dis Sci"},{"key":"2026010301015732400_izaf210-B6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/bjhp.12457","article-title":"Do specific types of sleep disturbances represent risk factors for poorer health related quality of life in inflammatory bowel disease? 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