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It highlights the potential of advanced therapies for this refractory inflammatory bowel disease phenotype with limited treatment options.<\/jats:p>","DOI":"10.1093\/ibd\/izaf216","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:43:18Z","timestamp":1756467798000},"page":"1197-1200","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic Benefit of Upadacitinib in Severe Post-Proctectomy (Class 4) Perianal Crohn\u2019s Disease: A Three-Patient Case Series"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8424-202X","authenticated-orcid":false,"given":"Luke Nathan","family":"Hanna","sequence":"first","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Imperial College London , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baseer","family":"Quraishi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Pelly","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Mark\u2019s Hospital & Academic Institute , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Lung","sequence":"additional","affiliation":[{"name":"Department of Radiology, St Mark\u2019s Hospital & Academic Institute , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2532-7267","authenticated-orcid":false,"given":"Phil","family":"Tozer","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Mark\u2019s Hospital & Academic Institute , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailsa","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Mark\u2019s Hospital & Academic Institute , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2070-4123","authenticated-orcid":false,"given":"Serre-Yu","family":"Wong","sequence":"additional","affiliation":[{"name":"The Dr Henry D. 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