{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:52:35Z","timestamp":1769835155206,"version":"3.49.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Seoul National University Bundang Hospital Research Fund","award":["02-2024-0040"],"award-info":[{"award-number":["02-2024-0040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Opioid use in Asian patients with inflammatory bowel disease (IBD) remains poorly understood. This study aimed to investigate the trends in chronic opioid use, associated clinical factors, and effects of advanced therapy (AT) on opioid use in Korean patients with IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This nationwide cohort study used administrative claims data from the Korean National Health Insurance Service (2010-2022). Chronic opioid use was defined as opioid use for \u226590\u2009days or \u22653 prescriptions within a calendar year. Logistic regression was used to identify clinical factors associated with chronic opioid use. The impact of AT on opioid use was analyzed through pre- and post-initiation comparisons using McNemar\u2019s tests, generalized estimating equations (GEE), and a linear mixed model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Chronic opioid use increased over the study period, with a higher prevalence in Crohn\u2019s disease (CD) than in ulcerative colitis (UC) (CD: 1.38%, UC: 0.53% in 2010; CD: 5.38%, UC: 1.98% in 2020). Among 49 548 newly diagnosed IBD patients, female sex, steroid and immunomodulator treatments, hospitalizations, emergency room visits, and mental disorders were positively associated with chronic opioid use in CD and UC. AT was positively associated with chronic opioid use in UC (odds ratio [OR] 1.627, P\u2009&amp;lt;\u2009.0001) but negatively associated with CD (OR 0.786, P\u2009=\u2009.0013). In CD, AT significantly reduced opioid users (McNemar\u2019s test: P\u2009&amp;lt;\u2009.0001; GEE: OR 0.478, P\u2009&amp;lt;\u2009.0001) and average daily doses (mean difference \u221215.8 morphine milligram equivalents, P\u2009=\u2009.0073).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Chronic opioid use has increased over the past decade among Korean patients with IBD, particularly among those with CD. AT is crucial for reducing opioid use in patients with CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf221","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T11:59:45Z","timestamp":1757073585000},"page":"245-252","source":"Crossref","is-referenced-by-count":1,"title":["Trends and Impacts of Advanced Therapy on Chronic Opioid Use in Asian Patients with Inflammatory Bowel Disease"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4046-8578","authenticated-orcid":false,"given":"Yu Kyung","family":"Jun","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital , Seongnam,","place":["South Korea"]},{"name":"Internal Medicine and Liver Research Institute, Seoul National University College of Medicine , Seoul,","place":["South 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