{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:25:05Z","timestamp":1792794305133,"version":"4.5.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Notaras Scholarship of the University of Sydney and Australia","id":[{"id":"https:\/\/ror.org\/0384j8v12","id-type":"ROR","asserted-by":"crossref"}]},{"name":"New Zealand Training Board in Colon and Rectal Surgery"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ileocolic resections (ICRs) are the most common resections for Crohn\u2019s disease. Historical control groups have often been used for comparison when assessing postoperative recurrence, usually with temporal bias. This study aimed to (1) report contemporary rates of postoperative recurrence requiring repeat surgery (surgical recurrence at anastomosis [surgical recurrence at the ileocolic resection site (SR-ICR)] or surgical recurrence at any site) and the rates of endoscopic recurrence (ER) in the \u201cbiologic era\u201d; and (2) determine risk factors for SR-ICR and ER.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective multicenter study involving 12 tertiary Australian centers was performed. Patients (of any age) who had undergone an ICR for Crohn\u2019s disease between 2007 and 2023 were included. Cox proportional hazards modeling was used to evaluate clinicopathological risk factors for SR-ICR and ER (defined as Rutgeerts grade \u2265i2b).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 875 patients were included (mean 38.7 \u00b1 15.1 years, 51% female). Median follow-up was 63.9\u2009months. Rates of SR-ICR were 4.5% (95% confidence interval [CI], 2.8%-6.1%) and 12.8% (95% CI, 8.8%-16.5%) at 5 and 10 years, respectively. Rates of surgical recurrence at any site were 5.6% (95% CI, 3.8%-7.5%) and 15.1% (95% CI, 11.0%-19.1%) at 5 and 10 years, respectively. Early (within 12 months) ER occurred in 24.7%. On multivariable analysis, smoking (adjusted hazard ratio, 3.49; 95% CI, 1.93-6.29) was the only factor significantly associated with SR-ICR. Smoking, positive microscopic margins, and granulomas were associated with ER, and prophylactic therapy and younger age at diagnosis (&amp;lt;17 years) were protective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The rate of SR at the ileocolic anastomosis in this large Australian cohort was low, recorded to be 1 in 20 at 5 years. Smoking remains the strongest risk factor for both ER and SR. Histopathological factors influence ER and should be considered in future risk prediction models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf244","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T11:57:28Z","timestamp":1759233448000},"source":"Crossref","is-referenced-by-count":2,"title":["Low Rates of Surgical Recurrence Following Ileocolic Resections for Crohn\u2019s Disease in the Biologic Era"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4968-0612","authenticated-orcid":false,"given":"Hugh L","family":"Giddings","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, Royal Prince Alfred Hospital , Sydney, New South Wales,","place":["Australia"]},{"name":"Surgical Outcomes Research Centre, Royal Prince Alfred Hospital , Sydney, New South Wales,","place":["Australia"]},{"name":"Institute of Academic Surgery, Royal Prince Alfred Hospital , Sydney, New South Wales,","place":["Australia"]},{"name":"Faculty of Medicine and Health, University of Sydney , Sydney, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kheng-Seong","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Royal Prince Alfred Hospital , Sydney, New South Wales,","place":["Australia"]},{"name":"Surgical Outcomes Research Centre, Royal Prince Alfred Hospital , Sydney, New South Wales,","place":["Australia"]},{"name":"Faculty of Medicine and Health, University of Sydney , Sydney, New South Wales,","place":["Australia"]},{"name":"Department of Colorectal Surgery, Concord Repatriation General Hospital , Sydney, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Solomon","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Royal Prince Alfred Hospital , Sydney, New South Wales,","place":["Australia"]},{"name":"Surgical Outcomes Research Centre, Royal Prince Alfred Hospital , Sydney, New South Wales,","place":["Australia"]},{"name":"Institute of Academic Surgery, Royal Prince Alfred Hospital , Sydney, New South Wales,","place":["Australia"]},{"name":"Faculty of Medicine and Health, University of Sydney , Sydney, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arteen","family":"Arzivian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St Vincent\u2019s Hospital , Sydney, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Haifer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St Vincent\u2019s Hospital , Sydney, New South Wales,","place":["Australia"]},{"name":"School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales , Sydney, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Concord Repatriation General Hospital , Sydney, New South Wales,","place":["Australia"]},{"name":"Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital , Tan Tock Seng,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Pappas","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Vincent\u2019s Private Hospital Northside , Brisbane, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2065-3012","authenticated-orcid":false,"given":"David","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Vincent\u2019s Private Hospital Northside , Brisbane, Queensland,","place":["Australia"]},{"name":"Department of Surgery, Royal Brisbane and Women\u2019s Hospital , Brisbane, Queensland,","place":["Australia"]},{"name":"Faculty of Medicine, University of Queensland , Brisbane, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Deacon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Queensland , Brisbane, Queensland,","place":["Australia"]},{"name":"Department of Gastroenterology and Hepatology, Royal Brisbane and Women\u2019s Hospital , Brisbane, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Radford-Smith","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Queensland , Brisbane, Queensland,","place":["Australia"]},{"name":"Department of Gastroenterology and Hepatology, Royal Brisbane and Women\u2019s Hospital , Brisbane, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nargus","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Royal Prince Alfred Hospital , Sydney, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Royal Adelaide Hospital , Adelaide, South Australia,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Royal Adelaide Hospital , Adelaide, South Australia,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roscoe","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St Vincent\u2019s Hospital , Sydney, New 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Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadon","family":"Karp","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Alfred Health , Melbourne, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Mater Hospital , Brisbane, Queensland,","place":["Australia"]},{"name":"Mater Research, University of Queensland , Brisbane, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Kyo","family":"An","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Mater Hospital , Brisbane, Queensland,","place":["Australia"]},{"name":"Mater Research, University of Queensland , Brisbane, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi Qin","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Liverpool Hospital , Sydney, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Liverpool Hospital , Sydney, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-3533","authenticated-orcid":false,"given":"Lena","family":"Thin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fiona Stanley Hospital , Murdoch, Western Australia,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Greeve","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Monash Health , Melbourne, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Monash Health , Melbourne, Victoria,","place":["Australia"]},{"name":"School of Clinical Sciences, Monash University , Melbourne, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J","family":"Connor","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Liverpool Hospital , Sydney, ,","place":["Australia"]},{"name":"New South Wales , Sydney, ,","place":["Australia"]},{"name":"Faculty of Medicine and Health, University of New South Wales , Sydney,","place":["Australia"]},{"name":"Crohn\u2019s Colitis Cure (CCCure) ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M","family":"Andrews","sequence":"additional","affiliation":[{"name":"Crohn\u2019s Colitis Cure (CCCure) ,","place":["Australia"]},{"name":"Department of Gastroenterology, Royal Adelaide Hospital , Adelaide, South Australia,","place":["Australia"]},{"name":"Faculty of Health Sciences, University of Adelaide , Adelaide, South Australia,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles P","family":"Sparrow","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Alfred Health , Melbourne, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Ghaly","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Concord Repatriation General Hospital , Sydney, New South Wales,","place":["Australia"]},{"name":"School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales , Sydney, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Australia and New Zealand Inflammatory Bowel Disease Consortium (ANZIBDC), Crohn\u2019s Colitis Cure (CCCure), Post Operative Recurrence and Surgical Outcomes following Crohn\u2019s Ileocolic Resections in Australia study (PORSCIA study collaborative)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"2025120303253053400_izaf244-B1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ajg.2009.579","article-title":"The natural history of adult Crohn\u2019s disease in population-based cohorts","volume":"105","author":"Peyrin-Biroulet","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"2025120303253053400_izaf244-B2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/SLA.0000000000003395","article-title":"Decreasing trends in intestinal resection and re-resection in Crohn\u2019s disease: a nationwide cohort 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