{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:58:56Z","timestamp":1787320736463,"version":"build-2736575974"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["21K08469"],"award-info":[{"award-number":["21K08469"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006004","name":"Tohoku University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006004","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical & Biological Laboratories Co., Ltd."},{"name":"Labor Sciences Research Grants for Research"},{"name":"Intractable Diseases from the Ministry of Health, Labour and Welfare of Japan","award":["U01DK062413"],"award-info":[{"award-number":["U01DK062413"]}]},{"name":"F. Widjaja Inflammatory Bowel Disease Institute of Cedars-Sinai Medical Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn\u2019s disease (CD), have complex pathologies requiring precise diagnostic tools. We evaluated the clinical utility of anti-integrin \u03b1v\u03b26 antibodies in diagnosing UC, focusing on differences between a U.S. cohort (self-reported White) and a Japanese cohort, and additionally assessed whether combining anti-\u03b1v\u03b26 with anti-EPCR improved diagnostic performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum anti-\u03b1v\u03b26 antibody levels were measured in 1138 participants (514 in the U.S. cohort, 624 in the Japanese cohort), including 1093 IBD cases and 45 healthy control subjects. Positivity rates and titers were compared between cohorts, and associations with clinical subphenotypes and anti-EPCR were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Anti-\u03b1v\u03b26 positivity was significantly higher in UC patients (85.4%) than in CD patients (16.4%) or control subjects (0%). Within UC, high positivity was observed across all disease extents, with only minor cohort differences. Longer disease duration was associated with lower positivity in both cohorts. In CD, the U.S. cohort showed higher positivity (23.4%) than the Japanese cohort (10.1%), particularly in colonic CD. Absence of ileal involvement, strictures, or perianal disease was associated with higher positivity. Anti-\u03b1v\u03b26 and anti-EPCR levels were strongly correlated, but their expression patterns differed in primary sclerosing cholangitis\u2013associated IBD. Combining anti-\u03b1v\u03b26 and anti-EPCR improved UC diagnostic accuracy (area under the curve, 0.98; 95% confidence interval, 0.95-1.00) over either antibody alone (P = .00264).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anti-\u03b1v\u03b26 is a valuable biomarker for UC diagnosis. However, this study demonstrated differences in its behavior between U.S. and Japanese cohorts, particularly in CD. Cohort-informed interpretation and combined antibody testing may improve diagnostic precision and disease stratification in IBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf246","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T12:05:39Z","timestamp":1759320339000},"page":"130-140","source":"Crossref","is-referenced-by-count":4,"title":["Differences in Anti-\u03b1v\u03b26 Integrin Antibody Expression between U.S. and Japanese Cohorts in Inflammatory Bowel Disease"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7042-009X","authenticated-orcid":false,"given":"Yoichi","family":"Kakuta","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai, 980-8574,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalin","family":"Li","sequence":"additional","affiliation":[{"name":"F. 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Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center , Los Angeles, CA, 90048,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideya","family":"Iwaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai, 980-8574,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai, 980-8574,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nagai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai, 980-8574,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Shimoyama","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai, 980-8574,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Naito","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai, 980-8574,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rintaro","family":"Moroi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai, 980-8574,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatake","family":"Kuroha","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai, 980-8574,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Shiga","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai, 980-8574,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Kinouchi","sequence":"additional","affiliation":[{"name":"Student Healthcare Center, Institute for Excellence in Higher Education, Tohoku University , Sendai, 980-8576,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6295-3494","authenticated-orcid":false,"given":"Tsuyoshi","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tohoku University Hospital , Sendai, 980-8574,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6885-6492","authenticated-orcid":false,"given":"Hiroshi","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tohoku University Hospital , Sendai, 980-8574,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot P B","family":"McGovern","sequence":"additional","affiliation":[{"name":"F. 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