{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:14:49Z","timestamp":1784556889504,"version":"3.55.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colonic surgery for Crohn\u2019s disease (CD) frequently involves sparing uninvolved segments of the colon. Few studies have assessed recurrence rates after segmental colectomy (SC). The aim of this study was to determine the rate of and identify the risk factors for postoperative CD recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a multicenter retrospective study from 3 tertiary inflammatory bowel disease (IBD) referral centers of CD patients who underwent SC between 2000 and 2019. We defined endoscopic recurrence as the presence of ulcers in the remaining colon upon postoperative colonoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 108 patients were included. Sixty-nine (63.9%) patients had evidence of postoperative CD endoscopic recurrence. Age at surgery &amp;lt;40\u2009years and disease duration \u2264156\u2009months predicted an increased likelihood for postoperative recurrence (odds ratio [OR], 2.43; P = .031 and OR, 3.29; P = .005, respectively), whereas abdominal perineal resection (OR, 0.21; P = .005), indication for SC of malignancy (OR, 0.14; P = .016), and postoperative use of tumor necrosis factor \u03b1 (TNF\u03b1) inhibitor for prophylactic purposes (OR, 0.38; P = .040) negatively predicted disease recurrence. Disease duration \u2264156\u2009months (OR, 2.86; P = .039) and postoperative TNF\u03b1 inhibitor prophylaxis remained significant (OR, 0.26; P = .013) upon multivariable modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although high rates of recurrence persist within the postoperative phase of SC for CD, the postoperative use of TNF\u03b1 inhibitor for prophylactic purposes for a subset of patients may promote a more durable endoscopic remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf252","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T11:41:19Z","timestamp":1760355679000},"page":"468-473","source":"Crossref","is-referenced-by-count":1,"title":["Disease Outcomes After Segmental Resection of Colonic Crohn\u2019s Disease: A Retrospective Multicenter Study"],"prefix":"10.1093","volume":"32","author":[{"given":"George","family":"Salem","sequence":"first","affiliation":[{"name":"Section of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma College of Medicine , Oklahoma City, OK 73104,","place":["United States"]},{"name":"Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD 21287,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3870-7469","authenticated-orcid":false,"given":"Christopher A","family":"Bouvette","sequence":"additional","affiliation":[{"name":"Section of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma College of Medicine , Oklahoma City, OK 73104,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Hernandez-Rocha","sequence":"additional","affiliation":[{"name":"Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital , Toronto, ON M5T 3L9,","place":["Canada"]},{"name":"Division of Gastroenterology and Hepatology, University of Toronto Temerty Faculty of Medicine , Toronto, ON M5T 3L9,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Hernandez Dominguez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Cat\u00f3lica of Chile , 8380453 Santiago,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Conner","sequence":"additional","affiliation":[{"name":"Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital , Toronto, ON M5T 3L9,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Silverberg","sequence":"additional","affiliation":[{"name":"Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital , Toronto, ON M5T 3L9,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L","family":"Cohen","sequence":"additional","affiliation":[{"name":"Digestive Diseases Institute, Cleveland Clinic Medical Center , Cleveland, OH 44195,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2549-9042","authenticated-orcid":false,"given":"Stefan","family":"Holubar","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Cleveland Clinic Foundation , Cleveland, OH 44195,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lazarev","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD 21287,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"2026072009221480100_izaf252-B1","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1053\/j.gastro.2003.09.029","article-title":"Mortality in inflammatory bowel disease: a population-based cohort study","volume":"125","author":"Card","year":"2003","journal-title":"Gastroenterology"},{"key":"2026072009221480100_izaf252-B2","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1097\/MIB.0000000000000742","article-title":"The economic and health-related impact of Crohn\u2019s disease in the United States: evidence from a nationally representative 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work-loss related costs","volume":"23","author":"Manceur","year":"2020","journal-title":"J Med Econ"},{"key":"2026072009221480100_izaf252-B6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/ibd\/izac050","article-title":"National prevalence of psychological distress and use of mental health care in inflammatory bowel disease","volume":"29","author":"Greywoode","year":"2023","journal-title":"Inflamm Bowel Dis"},{"key":"2026072009221480100_izaf252-B7","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1053\/j.gastro.2013.07.041","article-title":"Risk of surgery for inflammatory bowel diseases has decreased over time: a systematic review and meta-analysis of population-based studies","volume":"145","author":"Frolkis","year":"2013","journal-title":"Gastroenterology"},{"key":"2026072009221480100_izaf252-B8","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/1751-2980.13025","article-title":"Quantifying the rate of recurrence of postoperative Crohn\u2019s 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A meta-analysis","volume":"22","author":"Jain","year":"2021","journal-title":"J Dig Dis"},{"key":"2026072009221480100_izaf252-B9","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMoa0904492","article-title":"Infliximab, azathioprine, or combination therapy for Crohn\u2019s disease","volume":"362","author":"Colombel","year":"2010","journal-title":"N Engl J Med"},{"key":"2026072009221480100_izaf252-B10","first-page":"1","article-title":"ECCO-ESCP Consensus on Surgery for Crohn\u2019s Disease","volume":"12","author":"Bemelman","year":"2018","journal-title":"J Crohns Colitis"},{"key":"2026072009221480100_izaf252-B11","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1463-1318.2005.00903.x","article-title":"A comparison of segmental vs subtotal\/total colectomy for colonic Crohn\u2019s disease: a meta-analysis","volume":"8","author":"Tekkis","year":"2006","journal-title":"Colorectal 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