{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:52:40Z","timestamp":1772466760088,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mesenteric fat (MF) wrapping is a characteristic feature of Crohn\u2019s disease (CD). Current assessment methods are limited to binary classification (presence\/absence), restricting their utility in assessing disease progression and treatment response. This study aimed to develop and validate a novel semi-quantitative metric for grading MF wrapping using intestinal ultrasound (IUS), and to evaluate its reliability and clinical relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included 95 ultrasound scans from 63 patients with CD. The novel index described here categorized MF wrapping into 3 categories: none, incomplete, and complete. Images were independently assessed to evaluate inter- and intrarater reliability. Associations between MF wrapping and clinical characteristics, inflammatory markers, and IUS parameters were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Interrater reliability for the MF index was moderate (\u03ba\u2009=\u20090.452), while intrarater reliability was substantial (\u03ba\u2009=\u20090.653), similar to binary assessment (\u03ba\u2009=\u20090.572 and \u03ba\u2009=\u20090.674 for inter- and intrarater reliability, respectively). MF wrapping was significantly associated with increased bowel wall thickness (OR, 6.74; P &amp;lt; .001), loss of bowel wall stratification (OR, 22.05; P &amp;lt; .001), hyperemia (OR, 8.09; P = .002), and presence of strictures (OR, 4.30; P = .002). Smoking status and lower serum albumin were significantly associated with increased MF wrapping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CMFI represents a proof-of-concept tool for semi-quantitative assessment of MF wrapping on IUS. While reproducible and associated with other disease markers, its incremental clinical utility remains to be established through prospective validation and longitudinal outcome studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf268","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:11:51Z","timestamp":1760530311000},"page":"452-460","source":"Crossref","is-referenced-by-count":0,"title":["The Chicago Mesenteric Fat Index: A Novel Metric for Point-of-Care Intestinal Ultrasound Evaluation of Mesenteric Fat Wrapping in Crohn\u2019s Disease"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7393-4950","authenticated-orcid":false,"given":"Jo\u00eblle","family":"St-Pierre","sequence":"first","affiliation":[{"name":"University of Chicago Inflammatory Bowel Disease Center, University of Chicago Medicine, , 60637,","place":["United States"]},{"name":"University of Calgary Inflammatory Bowel Disease Unit, , Calgary, AB, T2N 4Z6,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-5341","authenticated-orcid":false,"given":"Amelia","family":"Kellar","sequence":"additional","affiliation":[{"name":"University of Chicago Inflammatory Bowel Disease Center, University of Chicago Medicine, , 60637,","place":["United States"]},{"name":"University of Chicago Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, , Chicago, IL, 60637,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessa","family":"George","sequence":"additional","affiliation":[{"name":"University of Chicago Inflammatory Bowel Disease Center, University of Chicago Medicine, , 60637,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Miyatani","sequence":"additional","affiliation":[{"name":"University of Chicago Inflammatory Bowel Disease Center, University of Chicago Medicine, , 60637,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1707-8560","authenticated-orcid":false,"given":"Noa","family":"Krugliak Cleveland","sequence":"additional","affiliation":[{"name":"University of Chicago Inflammatory Bowel Disease Center, University of Chicago Medicine, , 60637,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie K","family":"Choi","sequence":"additional","affiliation":[{"name":"University of Chicago Inflammatory Bowel Disease Center, University of Chicago Medicine, , 60637,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanhong","family":"Liao","sequence":"additional","affiliation":[{"name":"University of Chicago Biostatistics Laboratory and Research Computing Group, , Chicago, IL, 60637,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan","family":"Fear","sequence":"additional","affiliation":[{"name":"University of Chicago Inflammatory Bowel Disease Center, University of Chicago Medicine, , 60637,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zach","family":"Fine","sequence":"additional","affiliation":[{"name":"University of Chicago Inflammatory Bowel Disease Center, University of Chicago Medicine, , 60637,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Picker","sequence":"additional","affiliation":[{"name":"University of Chicago Inflammatory Bowel Disease Center, University of Chicago Medicine, , 60637,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5647-1723","authenticated-orcid":false,"given":"David T","family":"Rubin","sequence":"additional","affiliation":[{"name":"University of Chicago Inflammatory Bowel Disease Center, University of Chicago Medicine, , 60637,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"2026030209523800600_izaf268-B1","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/0002-9343(52)90025-9","article-title":"Regional ileitis. 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