{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T18:58:18Z","timestamp":1775156298092,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["Dnr 2020-02002"],"award-info":[{"award-number":["Dnr 2020-02002"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Regional Agreement on Medical Training and Clinical Research between Stockholm County Council and Karolinska Institutet","award":["Dnr RS2021-0855"],"award-info":[{"award-number":["Dnr RS2021-0855"]}]},{"name":"Karolinska Institutet Foundation","award":["Dnr: 2024-03131"],"award-info":[{"award-number":["Dnr: 2024-03131"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Opioids are not optimal for managing pain among patients with ulcerative colitis (UC), but the use of opiods in nationwide UC populations remains unexplored. We aimed to describe dispensed opioid use around UC diagnosis and annual trends among patients with prevalent UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a nationwide population-based cohort study of adults with an incident (2008-2020) or a prevalent (2006-2022) UC diagnosis and matched reference individuals from the general population. We obtained data on opioid dispensations and estimated the prevalence of having \u22651 dispensation per six-month period from two years before until five years following a first UC diagnosis. We also estimated annual opioid use among participants with a prevalent UC diagnosis and their matched reference individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 66\u2009929 adults with UC (including 25\u2009417 patients with an incident diagnosis) and 641\u2009609 matched reference individuals were included. Compared to reference individuals, patients with UC had a 1.3-fold higher prevalence of opioid use (6.4% vs 4.9%) two years before diagnosis, which peaked during the year of diagnosis (11.0%) and stabilized at a 1.7-fold higher use three to five years after diagnosis. Between 2006 and 2022 the annual prevalence of opioid use decreased by 15.0% in patients with UC and by 11.0% in reference individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this nationwide register-based study, adults with UC had higher prescribed opioid use within two years before and up to five\u2009years after first UC diagnosis compared with reference individuals. However, adults with prevalent UC (and reference individuals) had a declining temporal opioid use trend during 2006-2022.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf278","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:22:45Z","timestamp":1761222165000},"page":"677-687","source":"Crossref","is-referenced-by-count":0,"title":["Trends in Use of Prescribed Opioids in Incident and Prevalent Patients With Ulcerative Colitis: A Nationwide Study in Sweden"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9862-3665","authenticated-orcid":false,"given":"Mehdi","family":"Osooli","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siri","family":"Voghera","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustaf","family":"Bruze","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Nordenvall","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska University Hospital , Stockholm,","place":["Sweden"]},{"name":"Department of Pelvic Cancer, Unit of IBD-surgery, Karolinska University Hospital , Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-8516","authenticated-orcid":false,"given":"Charlotte R H","family":"Hedin","sequence":"additional","affiliation":[{"name":"Karolinska University Hospital, Centre for Digestive Health, Department of Gastroenterology Dermatovenereology and Rheumatology, Karolinska University Hospital , Stockholm,","place":["Sweden"]},{"name":"Department of Medicine Solna, Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa H","family":"Everhov","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet , Stockholm,","place":["Sweden"]},{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset, Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4r","family":"Myrelid","sequence":"additional","affiliation":[{"name":"Department of Surgery and Department of Biomedical and Clinical Sciences, Link\u00f6ping University , Link\u00f6ping,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1024-5602","authenticated-orcid":false,"given":"Jonas F","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm,","place":["Sweden"]},{"name":"Department of Pediatrics, \u00d6rebro University Hospital , \u00d6rebro,","place":["Sweden"]},{"name":"Division of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center , New York, NY,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Ol\u00e9n","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet , Stockholm,","place":["Sweden"]},{"name":"Sachs\u2019 Children and Youth Hospital, Stockholm South General Hospital , Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"SWIBREG Study 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