{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:18:30Z","timestamp":1783383510402,"version":"3.54.6"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Crohn disease is a debilitating inflammatory bowel disease lacking curative options for patients refractory to standard medical therapy. While autologous hematopoietic stem cell transplantation has demonstrated therapeutic potential in selected cases of refractory disease, there are no prior reports documenting its use in a repeat setting for this indication. A 48-year-old male patient with severe, refractory Crohn disease who failed comprehensive medical management, including multiple biologic agents is presented. Following a rapid clinical relapse six months after an initial non-myeloablative autologous hematopoietic stem cell transplantation, a second procedure was performed three years later using the same mobilization and conditioning regimen (cyclophosphamide and rabbit anti-thymocyte globulin), with the addition of one year of post-transplant cyclosporine to maintain sustained immunosuppression. At 30 months following the second autologous hematopoietic stem cell transplantation, the patient remains in sustained clinical and endoscopic remission off all immunosuppressive and biologic medications. This case documents the feasibility and favorable long-term outcome of a second non-myeloablative autologous hematopoietic stem cell transplantation, suggesting this approach may be a valid and effective salvage option for highly selected patients with severe, refractory Crohn disease.<\/jats:p>","DOI":"10.1093\/ibd\/izaf292","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T13:00:55Z","timestamp":1763038855000},"page":"1415-1417","source":"Crossref","is-referenced-by-count":0,"title":["Sustained Clinical Remission Following a Second Autologous Hematopoietic Stem Cell Transplantation for Refractory Crohn Disease"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2212-4883","authenticated-orcid":false,"given":"Milton Artur","family":"Ruiz","sequence":"first","affiliation":[{"name":"Associa\u00e7\u00e3o Portuguesa de Benefic\u00eancia de S\u00e3o Jos\u00e9 do Rio Preto BMT Department, , Lu\u00edz Vaz de Cam\u00f5es, 3150 - Vila Redentora , S\u00e3o Jos\u00e9 do Rio Preto, SP, 15015-750,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1952-1255","authenticated-orcid":false,"given":"Roberto Luiz","family":"Kaiser Junior","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o Portuguesa de Benefic\u00eancia de S\u00e3o Jos\u00e9 do Rio Preto BMT Department, , Lu\u00edz Vaz de Cam\u00f5es, 3150 - Vila Redentora , S\u00e3o Jos\u00e9 do Rio Preto, SP, 15015-750,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3046-2117","authenticated-orcid":false,"given":"Gabriel","family":"Piron-Ruiz","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o Portuguesa de Benefic\u00eancia de S\u00e3o Jos\u00e9 do Rio Preto BMT Department, , Lu\u00edz Vaz de Cam\u00f5es, 3150 - Vila Redentora , S\u00e3o Jos\u00e9 do Rio Preto, SP, 15015-750,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"2026070620112362000_izaf292-B1","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.14309\/ajg.0000000000003465","article-title":"ACG clinical guideline: management of Crohn\u2019s disease in adults","volume":"120","author":"Lichtenstein","year":"2025","journal-title":"Am J Gastroenterol"},{"key":"2026070620112362000_izaf292-B2","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/bjh.12579","article-title":"Second autologous transplant as salvage therapy in multiple myeloma","volume":"163","author":"Atanackovic","year":"2013","journal-title":"Br J Haematol"},{"key":"2026070620112362000_izaf292-B3","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.1080\/10428194.2020.1789624","article-title":"Second autologous stem cell transplantation for relapsed\/refractory Hodgkin lymphoma after a 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Crohn\u2019s disease","volume":"10","author":"Ruiz","year":"2017","journal-title":"BMC Res Notes"},{"key":"2026070620112362000_izaf292-B9","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1093\/rheumatology\/kez010","article-title":"Second autologous haematopoietic stem cell transplantation in systemic sclerosis\u2014a case report","volume":"58","author":"van Rhijn-Brouwer","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"2026070620112362000_izaf292-B10","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1196\/annals.1361.110","article-title":"Rationale for T cell inhibition by cyclosporin A in major autoimmune diseases","volume":"1051","author":"Ferraccioli","year":"2005","journal-title":"Ann N Y Acad Sci"}],"container-title":["Inflammatory Bowel 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