{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:35:54Z","timestamp":1792290954382,"version":"4.4.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>There are limited data on the impact of glucagon-like peptide-1 receptor agonist (GLP-1RA) on the risk of recurrent pouchitis after ileal pouch\u2013anal anastomosis (IPAA) for ulcerative colitis (UC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted in the TriNetX Research Network in adult patients with obesity and IPAA for UC with a history of pouchitis in whom a GLP-1RA was initiated compared to those patients in whom a GLP-1RA was not initiated. The primary outcome was the risk of recurrent pouchitis within 12\u2009months. The secondary outcomes were mean number of antibiotic prescriptions, anti-diarrheal medication use, Crohns-like disease of pouch (CLDP), and pouch excision. One-to-one propensity score matching was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 43 UC-IPAA patients with obesity and history of pouchitis (mean age 51.7\u2009\u00b1\u200914.7\u2009years, mean body mass index [BMI] 34.4\u2009\u00b1\u20096\u2009kg\/m2, 60.4% female). After propensity score matching, the GLP-1RA cohort had a significantly decreased risk of recurrent pouchitis (26.3% vs 52.6%; adjusted odds ratio [aOR], 0.32; 95% CI, 0.12-0.84) compared to the control cohort. Mean antibiotic prescriptions were numerically lower in the GLP-1RA cohort (2 vs 4.4, P\u2009=\u2009.16). Anti-diarrheal medication use was lower in the GLP-1RA cohort (18.4% vs 47.3%; aOR, 0.23; 95% CI, 0.07-0.67). There was no difference in the risk of CLDP. Zero patients required pouch excision in both cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study in a small cohort of patients with UC-IPAA and obesity with a history of pouchitis showed that GLP-1RA use was associated with decreased risk of recurrent pouchitis and anti-diarrheal medication use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf301","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:08:15Z","timestamp":1763557695000},"page":"869-874","source":"Crossref","is-referenced-by-count":5,"title":["Real-World Outcomes of Glucagon-Like Peptide-1 Receptor Agonist Therapy in Obese Patients With Ulcerative Colitis and IPAA With a History of Pouchitis"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6604-7712","authenticated-orcid":false,"given":"Aakash","family":"Desai","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology & Nutrition, Allegheny Health Network , Pittsburgh, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medicine Institute, Allegheny Health Network , Pittsburgh, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himsikhar","family":"Khataniar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medicine Institute, Allegheny Health Network , Pittsburgh, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis A","family":"Farraye","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic , Jacksonville, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-2767","authenticated-orcid":false,"given":"Priya","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Thomas Jefferson University Hospital , Philadelphia, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L","family":"Barnes","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill , Chapel Hill, NC,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-2760","authenticated-orcid":false,"given":"Gursimran S","family":"Kochhar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology & Nutrition, Allegheny Health Network , Pittsburgh, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana G","family":"Hashash","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic , Jacksonville, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"2026050317364430200_izaf301-B1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.gtc.2020.09.001","article-title":"Surgical management of ulcerative colitis","volume":"49","author":"Grieco","year":"2020","journal-title":"Gastroenterol Clin North Am"},{"key":"2026050317364430200_izaf301-B2","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.cgh.2022.04.015","article-title":"Increasing incidence of pouchitis between 1996 and 2018: a population-based Danish cohort study","volume":"21","author":"Barnes","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026050317364430200_izaf301-B3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s11605-013-2353-8","article-title":"Obesity increases risk for pouch-related complications following restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA)","volume":"18","author":"Klos","year":"2014","journal-title":"J Gastrointest Surg"},{"issue":"1 Suppl 1","key":"2026050317364430200_izaf301-B4","first-page":"S167","article-title":"American Diabetes Association Professional Practice Committee. 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