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Limited studies have evaluated the role of IUS during routine clinical care. This study investigated the addition of IUS as part of routine clinic visits compared to standardized indices collected in real-world care to evaluate the role of IUS as a treat-to-target measure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included pediatric patients (&amp;lt;18-years-old) with IBD who underwent IUS as part of clinical care. The primary outcome compared the accuracy of IUS with clinical indices versus clinical indices alone to predict biochemical disease activity using receiver operating characteristics. Secondary outcomes evaluated differences in bowel wall thickness (BWT) based on biochemical disease activity and level of clinical severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 92 patients with 136 IUS exams. The addition of IUS markers to clinical parameters improved prediction of biochemical activity in CD (AUC 0.71 versus 0.90; P\u2009=\u2009.004) and trended toward improvement in UC (AUC 0.83 versus 0.92; P\u2009=\u2009.067). Patients with active disease had higher BWT than those with quiescent disease. Median BWT for FCP activity was 4.2\u2009mm (IQR: 2.7-5.0\u2009mm) versus 2.0\u2009mm (IQR: 1.6-2.7\u2009mm; P\u2009&amp;lt; .001) for FCP remission (\u2264250\u00b5g\/g). Optimal BWT thresholds to predict FCP\u2009&amp;gt; 250 ranged between 2.3-2.5\u2009mm, based on disease phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Integrating IUS with clinical symptoms during routine clinic visits was superior to shPCDAI alone in predicting CD activity, and may potentially be superior to PUCAI for UC. Incorporating IUS into routine visits may accelerate treatment decisions, thereby advancing an improved point-of-care treat-to-target approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf337","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:57:21Z","timestamp":1766581041000},"page":"1097-1105","source":"Crossref","is-referenced-by-count":2,"title":["Integrating intestinal ultrasound into routine clinical care improves prediction of biochemical disease activity in pediatric inflammatory bowel disease"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8287-3424","authenticated-orcid":false,"given":"Perseus V","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Stanford University School of Medicine , Palo Alto, CA,","place":["United States"]},{"name":"Stanford Medicine Children\u2019s 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