{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:18:59Z","timestamp":1788286739221,"version":"build-2803163510"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Treatment strategies for Crohn disease (CD) have evolved considerably over recent decades. Approximately 65% of primary resections for CD comprise ileocolic resections (ICR). Currently, up-to-date data are not available on surgical recurrence risk after primary ICR, as previous meta-analyses combined various types of intestinal resections. As such, we aimed to assess the incidence, predictors, and trends of surgical recurrence after primary ICR for CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE, EMBASE, and the Cochrane database were searched from inception until November 15, 2023. Studies were included if they described the surgical recurrence risk after a primary ICR for CD. The primary endpoint was surgical recurrence, defined as reoperation due to disease recurrence in the neoterminal ileum. Meta-analyses were performed to (1) evaluate trends in surgical recurrence over time, (2) estimate the risk of surgical recurrence in the biologics era (post-2000), and (3) identify risk factors for surgical recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 3498 articles screened, 55 were included, of which 31 studies reported cumulative 5- and\/or 10-year surgical recurrence rates (study inclusion period: 1932-2020; n = 28\u2009354 patients). Meta-regression analysis indicated a declining trend in both 5- and 10-year surgical recurrence rates, which stabilized after 2000. In the biologics era, pooled 5- and 10-year surgical recurrence risks were 5.7% (95% CI, 3.9-8.4) and 13.0% (8.3-19.7), respectively. Smoking, patient sex, perianal disease, and behavior were not significantly prognostic for surgical recurrence after primary ICR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Approximately 1 in 17 patients experience surgical recurrence within 5\u2009years after primary ICR. The risk of surgical recurrence decreased over the past decades but has stabilized in the biologics era.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>PROSPERO registration No. CRD42020213027.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izag037","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T12:42:05Z","timestamp":1772196125000},"page":"1815-1832","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and predictors of surgical recurrence after primary ileocolic resection in Crohn ileitis: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0459-9673","authenticated-orcid":false,"given":"Anouck E G","family":"Haanappel","sequence":"first","affiliation":[{"name":"Amsterdam UMC, location Vrije Universiteit, Department of Surgery , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline M L","family":"van der Does de Willebois","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, location Vrije Universiteit, Department of Surgery , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-6323","authenticated-orcid":false,"given":"Mahsoem","family":"Ali","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, location Vrije Universiteit, Department of Surgery , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faridi S","family":"Jamaludin","sequence":"additional","affiliation":[{"name":"Medical Library AMC, Amsterdam UMC, University of Amsterdam , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4814-9376","authenticated-orcid":false,"given":"Marjolijn","family":"Duijvestein","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Radboud UMC , Nijmegen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christianne J","family":"Buskens","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, location Vrije Universiteit, Department of Surgery , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem A","family":"Bemelman","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, location Vrije Universiteit, Department of Surgery , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Joline","family":"de Groof","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, location Vrije Universiteit, Department of Surgery , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"2026090114022411400_izag037-B1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1001\/jama.1984.03340250053024","article-title":"Landmark article Oct 15, 1932. 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