{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:07:27Z","timestamp":1785298047249,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The treatment of Crohn\u2019s perianal fistula remains challenging owing to its recurrent nature and resistance to complete healing. This study aimed to assess the postoperative outcomes, including fistula closure rates, following Crohn\u2019s perianal fistula surgery, with and without polydeoxyribonucleotide administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review was conducted on patients who underwent fistula closure operations for Crohn\u2019s perianal fistula at a single tertiary center in Seoul, Korea, between January 2018 and June 2024. Patients were divided into two groups based on the use of local polydeoxyribonucleotide (PDRN) injections during fistula closure operations, and clinical variables and postoperative outcomes were compared between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 47 patients, 21 (44.7%) were assigned to the PDRN group and 26 (55.3%) were assigned to non-PDRN group. Baseline characteristics between the two groups showed no significant difference. During the mean follow-up of 30.4\u2009months, patients in the PDRN group demonstrated a significantly higher complete fistula closure rate (70.0% vs 26.9% at 6\u2009months, and 83.3% vs 46.2% at 12\u2009months; P\u2009=\u2009.005), and a shorter time from surgery to complete closure (3.3\u2009\u00b1\u20092.6\u2009months vs 5.9\u2009\u00b1\u20093.8\u2009months; P\u2009=\u2009.044), compared with the non-PDRN group. Multivariate analysis revealed PDRN as an independent factor significantly associated with Crohn\u2019s perianal fistula closure (HR 2.336; 95% CI, 1.092-4.997, P\u2009=\u2009.029).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PDRN is a potential therapeutic agent that presents a viable option for Crohn\u2019s perianal fistula surgery, improving complete fistula closure rate through a safe, cost-effective, and relatively simple procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izag047","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:51:58Z","timestamp":1772628718000},"page":"1471-1480","source":"Crossref","is-referenced-by-count":0,"title":["Effect of polydeoxyribonucleotide as a potential therapeutic agent to enhance the healing of Crohn\u2019s perianal fistula"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-0606","authenticated-orcid":false,"given":"Hyeon Kyeong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine, St. Vincent\u2019s Hospital, The Catholic University of Korea , Address 93, Jungbu-daero, Paldal-gu, Suwon-si, Gyeonggi-do, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3196-8423","authenticated-orcid":false,"given":"Yong Sik","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5878-8000","authenticated-orcid":false,"given":"Jong Lyul","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-2690","authenticated-orcid":false,"given":"Eun Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9414-7817","authenticated-orcid":false,"given":"Min Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0212-9196","authenticated-orcid":false,"given":"Young Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2382-0939","authenticated-orcid":false,"given":"Chan Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5355-3969","authenticated-orcid":false,"given":"In Ja","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8824-4808","authenticated-orcid":false,"given":"Seok-Byung","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-9981","authenticated-orcid":false,"given":"Chang 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