{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:56:35Z","timestamp":1793044595298,"version":"4.5.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The IBSEN III"},{"name":"Takeda Pharmaceuticals"},{"name":"Foundation Dam"},{"name":"Norwegian South-Eastern Health Authorities"},{"DOI":"10.13039\/501100004785","name":"NordForsk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004785","id-type":"DOI","asserted-by":"publisher"}]},{"name":"90569"},{"DOI":"10.13039\/501100001858","name":"Vinnova","doi-asserted-by":"publisher","award":["2019-01185"],"award-info":[{"award-number":["2019-01185"]}],"id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["2988039"],"award-info":[{"award-number":["2988039"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Regional Health Authorities South-Eastern Norway","award":["2020066"],"award-info":[{"award-number":["2020066"]}]},{"DOI":"10.13039\/100004807","name":"DFG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Excellence Cluster 2167"},{"name":"Precision Medicine in Chronic Inflammation"},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["327634"],"award-info":[{"award-number":["327634"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Despite the well-established involvement of the gut microbiome in inflammatory bowel disease (IBD), less is known about how the gut microbiome changes over time and how it varies with clinical disease activity and fecal calprotectin (f-calprotectin). To address this gap, we utilized samples from the population-based inception cohort of the Inflammatory Bowel Disease in South-Eastern Norway III (IBSEN III) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data and stool samples from study participants with IBD and symptomatic controls were collected at diagnosis and after 3, 6, and 12\u2009months. Microbiome profiling of stool samples was performed targeting the V3-V4 region of the 16S rRNA gene, and a consensus-based approach of mixed models was employed for the longitudinal microbiome analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 1251 samples from 744 patients with ulcerative colitis, 618 samples from 356 patients with Crohn\u2019 s disease and 266 samples from 164 symptomatic non-IBD controls. In the IBD population, we observed that levels of f-calprotectin decreased over time, as did the patient-reported disease activity (P\u2009&amp;lt;\u2009.001). Distinct changes in the gut microbiome of IBD patients were observed throughout the first year, such as increased alpha diversity (P\u2009&amp;lt;\u2009.001) and significant taxonomic changes.<\/jats:p>\n                    <jats:p>Notably, there was no covariation between the changes in alpha diversity and f-calprotectin or symptom score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The gut microbiome during the first year after IBD diagnosis showed changes that paralleled inflammation and clinical disease activity, albeit without covariation, suggesting that there may be a disease-driving impact of gut microbiome independent of inflammation and inflammation-driven symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izag051","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T12:43:48Z","timestamp":1772714628000},"page":"1695-1706","source":"Crossref","is-referenced-by-count":1,"title":["Disentangling the gut microbiome and inflammation in inflammatory bowel diseases: longitudinal observations from the IBSEN III study"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3053-0267","authenticated-orcid":false,"given":"Maria G","family":"Maseng","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo , 0371 Oslo,","place":["Norway"]},{"name":"Department of Gastroenterology, Division of Medicine, Oslo University Hospital , 0450 Oslo,","place":["Norway"]},{"name":"Bio-Me AS , 0349 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