{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:18:49Z","timestamp":1788286729417,"version":"build-2803163510"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Patients with stricturing\/penetrating Crohn disease had significantly more hypertrophic\/keloid scars than those with nonstricturing disease in this cross-sectional proof-of-concept study, suggesting potential shared fibrotic mechanisms between cutaneous and intestinal fibrosis. If corroborated in larger and more longitudinal cohorts, overcoming potential confounders such as postsurgical scars, this novel association may help identify patients at risk and facilitate development of targeted antifibrotic therapies.<\/jats:p>","DOI":"10.1093\/ibd\/izag058","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:36:50Z","timestamp":1774355810000},"page":"1843-1848","source":"Crossref","is-referenced-by-count":0,"title":["Skin-deep connections: likelihood of skin-scarring history in patients with stricturing\/penetrating Crohn disease compared with patients with nonstricturing\/nonpenetrating disease and non\u2013inflammatory bowel disease controls"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2263-8893","authenticated-orcid":false,"given":"Mustafa","family":"Mohamedrashed","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Northern Health , Epping, VIC, 3076,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiumaeswar","family":"Yogakanthi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Northern Health , Epping, VIC, 3076,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayushi","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Northern Health , Epping, VIC, 3076,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Northern Health , Epping, VIC, 3076,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northern Health , Epping, VIC, 3076,","place":["Australia"]},{"name":"Department of Medicine, University of Melbourne , Melbourne, VIC,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-3589","authenticated-orcid":false,"given":"Mayur","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Northern Health , Epping, VIC, 3076,","place":["Australia"]},{"name":"Department of Medicine, University of Melbourne , Melbourne, VIC,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"2026090114012149700_izag058-B1","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1136\/gutjnl-2012-304353","article-title":"Crohn\u2019s disease complicated by strictures: a systematic review","volume":"62","author":"Rieder","year":"2013","journal-title":"Gut"},{"key":"2026090114012149700_izag058-B2","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/S2468-1253(21)00393-9","article-title":"Intensive drug therapy versus standard drug therapy for symptomatic intestinal Crohn\u2019s disease strictures (STRIDENT): an open-label, single-centre, randomised controlled trial","volume":"7","author":"Schulberg","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2026090114012149700_izag058-B3","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/ueg2.12568","article-title":"Intestinal strictures in Crohn\u2019s disease: an update from 2023","volume":"12","author":"Liu","year":"2024","journal-title":"United European Gastroenterol J."},{"key":"2026090114012149700_izag058-B4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1136\/bmj.326.7380.88","article-title":"Skin scarring","volume":"326","author":"Bayat","year":"2003","journal-title":"BMJ"},{"key":"2026090114012149700_izag058-B5","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J Pathol"},{"key":"2026090114012149700_izag058-B6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2119\/molmed.2009.00153","article-title":"Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies","volume":"17","author":"Gauglitz","year":"2011","journal-title":"Mol Med"},{"key":"2026090114012149700_izag058-B7","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1089\/wound.2020.1386","article-title":"A scoping review of the methodology used in studies of genetic influences on the development of keloid or hypertrophic scarring in adults and children after acute wounding","volume":"10","author":"Davies","year":"2021","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"2026090114012149700_izag058-B8","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.cgh.2017.05.047","article-title":"Ethnicity influences phenotype and outcomes in inflammatory bowel disease: a systematic review and meta-analysis of population-based studies","volume":"16","author":"Shi","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026090114012149700_izag058-B9","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1053\/j.gastro.2016.09.047","article-title":"Mechanisms, management, and treatment of fibrosis in patients with inflammatory bowel diseases","volume":"152","author":"Rieder","year":"2017","journal-title":"Gastroenterology"},{"key":"2026090114012149700_izag058-B10","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1136\/gutjnl-2011-301668","article-title":"Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn\u2019s disease: unexpected results of a randomised, double-blind placebo-controlled trial","volume":"61","author":"Hueber","year":"2012","journal-title":"Gut"},{"key":"2026090114012149700_izag058-B11","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1111\/j.1572-0241.2006.00463.x","article-title":"Factors associated with the development of intestinal strictures or obstructions in patients with Crohn\u2019s disease","volume":"101","author":"Lichtenstein","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"2026090114012149700_izag058-B12","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/1751-2980.12913","article-title":"Serum biomarkers of fibrostenotic Crohn\u2019s disease: where are we now?","volume":"21","author":"He","year":"2020","journal-title":"J Dig Dis"}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/32\/9\/1843\/68070857\/izag058.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/32\/9\/1843\/68070857\/izag058.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:01:45Z","timestamp":1788285705000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/32\/9\/1843\/8653297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":12,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,4,13]]},"published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izag058","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,4,13]]}}}