{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:49:54Z","timestamp":1787237394512,"version":"build-2736575974"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003761","name":"University Medical Center Utrecht","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003761","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Interuniversity Special Research Fund (\u201cModulating Immunity and the Microbiome for Effective CRC Immunotherapy\u201d"},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["1SH6624N"],"award-info":[{"award-number":["1SH6624N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The dysregulated immune response in Crohn\u2019s disease might result from disturbances in the T cell receptor (TCR) repertoire. To investigate this hypothesis, we compared the peripheral TCR repertoire within T cell subsets in twin pairs concordant and discordant for Crohn\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed TCR\u03b1 and TCR\u03b2 sequencing on peripheral flow-sorted CD4+ memory gut-homing (integrin \u03b14\u03b27), non\u2013gut-homing (integrin \u03b14\u03b27\u2212), and regulatory T cells (Tregs) from Dutch monozygotic Crohn\u2019s disease concordant twins (n\u2009=\u20098), monozygotic Crohn\u2019s disease discordant twins (n\u2009=\u20098), and healthy control subjects (n\u2009=\u20094). TCR diversity and clonality, overlap between individuals, convergence and enrichment, and clustering of the TCR repertoire was studied and compared with previously reportd Crohn\u2019s disease\u2013related TCRs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall diversity and clonality was comparable between Crohn\u2019s disease patients, healthy cotwins, and healthy control subjects. Comparing T cell subsets, a decreased diversity and increased clonality was observed for Tregs. Concordant Crohn\u2019s disease twins had an increased overlap in TCRs for Tregs and CD4+ memory gut-homing T cells. Using TCR convergence, enrichment, and subsequent clustering analyses, we identified 8 clusters of TCRs potentially related with Crohn\u2019s disease. The identified Crohn\u2019s disease\u2013related TCR signatures have not previously been described in relation to Crohn\u2019s disease and thus far have mostly unknown antigen specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased overlap in the TCR repertoires of monozygotic twin pairs concordant for Crohn\u2019s disease suggest that (antigen-driven) skewing of the TCR repertoire could play a role in the pathophysiology of Crohn\u2019s disease. The identified TCR-based Crohn\u2019s disease signatures are prime targets for further study into the pathophysiology of Crohn\u2019s disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izag078","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:34:56Z","timestamp":1776166496000},"page":"1561-1575","source":"Crossref","is-referenced-by-count":1,"title":["Clonal overlap and convergent clustering of T cell receptor signatures in Crohn\u2019s disease in monozygotic twins"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5195-0562","authenticated-orcid":false,"given":"Eelco C","family":"Brand","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht University , Utrecht, 3584 CX,","place":["the Netherlands"]},{"name":"Center for Translational Immunology, University Medical Center Utrecht, Utrecht University , Utrecht, 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