{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:59:57Z","timestamp":1790794797794,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Pediatric Research Foundation"},{"name":"Helsinki University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Perianal Crohn\u2019s disease (pCD) is a severe pediatric phenotype with high morbidity. Although antitumor necrosis factor (TNF) agents are first-line therapy, remission is not achieved in a subset of patients. We aimed to evaluate clinical and radiological outcomes of ustekinumab (UST) in pediatric patients with pCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a multicenter retrospective study including pediatric patients with pCD treated with UST between 2016 and 2023. Primary outcomes were clinical and radiological remission at predefined time points. Clinical remission was defined as absence of fistula drainage without antibiotics or unplanned perianal interventions. Radiological remission was defined as a Pediatric MRI-Based perianal Crohn\u2019s Disease (PEMPAC) score of\u2009&amp;lt;10 on pelvic MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty patients were included, of whom 2 were anti-TNF-naive. The median age at UST initiation was 15\u2009years (IQR 12.4-16.2). Clinical remission was observed in 46% (23\/50; P\u2009=\u2009.006 vs baseline), 48% (23\/48; P\u2009=\u2009.036 vs baseline), and 42% (19\/45; P\u2009=\u2009.13 vs baseline) at weeks 26, 52, and 104, respectively. Radiological remission was 29% (10\/34) and 30% (13\/43) at weeks 52 and 104, respectively (both P\u2009&amp;lt;\u2009.01 vs baseline). In multivariable analysis, higher baseline PEMPAC scores were independently associated with lower odds of both clinical (P\u2009&amp;lt;\u2009.01; OR 0.88, 95% CI 0.68-0.95) and radiological remission (P\u2009&amp;lt;\u2009.01; OR 0.81, 95% CI 0.62-0.94).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>UST was associated with perianal clinical remission in a substantial proportion of pediatric patients, approaching 50% at 1\u2009year, and radiological healing in about one-third at 2\u2009years, supporting its potential role in pediatric pCD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izag091","type":"journal-article","created":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T11:33:58Z","timestamp":1778412838000},"page":"1871-1879","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and radiological outcomes of ustekinumab in pediatric perianal Crohn\u2019s disease: a multicenter retrospective study from the Pediatric IBD Porto Group of ESPGHAN"],"prefix":"10.1093","volume":"32","author":[{"given":"Ido","family":"Orlin","sequence":"first","affiliation":[{"name":"Leumit Health Services , Haifa,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balsam","family":"Younis","sequence":"additional","affiliation":[{"name":"Pediatric Department, Emek Medical Center , Afula,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gasparetto","sequence":"additional","affiliation":[{"name":"School of Medicine, Norfolk and Norwich University Hospital, Jenny Lind Children\u2019s Hospital, Pediatric Gastroenterology, University of East Anglia (UEA) , Norwich,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Yerushalmy-Feler","sequence":"additional","affiliation":[{"name":"Pediatric 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Bern,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pejman","family":"Rohani","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Research Center, Department of Pediatrics, Children Medical Center, TUMS , Tehran,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00fdna","family":"Z\u00e1rubov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, 2nd Faculty of Medicine, Gastroenterology and Nutrition Unit, Charles University and University Hospital Motol , Prague,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"D\u2019Arcangelo","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza-University of Rome , Rome,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Pochesci","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children and Young People , Edinburgh,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Lozano-Ruf","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Hospital Sant Joan de D\u00e9u , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9170-8415","authenticated-orcid":false,"given":"Kaija-Leena","family":"Kolho","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Children\u2019s Hospital, University of Helsinki and HUS , 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