{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:59:01Z","timestamp":1781045941371,"version":"3.54.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Ulcerative colitis (UC) is characterized by continuous mucosal inflammation beginning in the rectum with variable proximal extension. However, up to 17% of patients demonstrate patchy cecal inflammation known as a periappendiceal red patch (PARP). Although PARP has historically been linked to severe disease and worse outcomes, its long-term clinical significance remains unclear. We conducted a systematic review and meta-analysis to evaluate outcomes in UC patients with isolated PARP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search of MEDLINE, Embase, Scopus, and Cochrane CENTRAL was performed to identify studies comparing UC patients with and without endoscopic or histologic evidence of PARP. Meta-analysis was conducted using R (version 4.4.3). Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated, and between-study heterogeneity was assessed using Higgins\u2019 I2 statistic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen nonrandomized studies, including 2289 UC patients (PARP+: 725; PARP\u2212: 1564), were analyzed. PARP was significantly associated with higher odds of proctitis (OR, 1.54; 95% CI, 1.09-2.18; P\u2009=\u2009.02). No significant associations were observed between PARP and left-sided colitis (OR, 0.88; 95% CI, 0.57-1.35; P\u2009=\u2009.51) or extensive colitis (OR, 0.84; 95% CI, 0.50-1.41; P\u2009=\u2009.45). PARP was not associated with disease progression, pharmacotherapeutic escalation, or colectomy. However, moderate-to-high heterogeneity was observed across most of the outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PARP is more frequently observed in patients with ulcerative proctitis but does not appear to influence long-term disease progression or major clinical outcomes, supporting its classification as a benign endoscopic finding in UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izag092","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:46:55Z","timestamp":1778154415000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical significance of isolated periappendiceal red patch in ulcerative colitis: A systematic review, meta-analysis, and 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