{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:35Z","timestamp":1792785935109,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"International Joint Research Grant of the Korean Association for the Study of Intestinal Diseases","award":["2022-3"],"award-info":[{"award-number":["2022-3"]}],"id":[{"id":"https:\/\/ror.org\/00wcwkf45","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Kyungpook National University Research Fund","award":["2025"],"award-info":[{"award-number":["2025"]}],"id":[{"id":"https:\/\/ror.org\/040c17130","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to develop predictive models for acute severe ulcerative colitis (ASUC) using data from East Asian (EA) patients and to validate their performance in an Australia\/New Zealand (ANZ) cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective international study was conducted across 23 referral hospitals in EA and ANZ, enrolling consecutive ASUC patients between January 2015 and December 2022. Logistic regression analyses were used to construct predictive models for 1-year colectomy and non-response to corticosteroid therapy (NRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 826 patients with ASUC were included (411 EA and 415 ANZ). Among EA patients, independent predictors of 1-year colectomy included female sex, prior exposure to tumor necrosis factor inhibitors, and admission albumin\u2009\u22643\u2009g\/dL. Independent predictors of NRS in the EA cohort were age at diagnosis \u2009\u226437\u2009years, baseline steroid use, admission albumin \u22642.5\u2009g\/dL, and the presence of extraintestinal manifestations. The EA-derived scoring systems demonstrated strong predictive performance within the EA cohort (1-year colectomy: P\u2009&amp;lt;\u2009.0001; NRS: P\u2009=\u2009.001) but showed limited utility in the ANZ cohort (P\u2009=\u2009.106 and P\u2009=\u2009.012). In contrast, European-developed models\u2014including the French 1-year colectomy score and the ADMIT-ASC index for NRS\u2014accurately predicted outcomes in the ANZ cohort (P\u2009=\u2009.007 and P\u2009&amp;lt;\u2009.0001) but had reduced predictive capacity in the EA cohort (P\u2009=\u2009.106 and P\u2009=\u2009.026). These findings were consistent in both cohorts following propensity score matching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Predictive factors for ASUC differ substantially between EA and ANZ patients, highlighting the need for population-specific predictive tools.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izag098","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:49:10Z","timestamp":1778932150000},"page":"1957-1968","source":"Crossref","is-referenced-by-count":0,"title":["Distinct predictive factors for acute severe ulcerative colitis in East Asian and Western populations"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0806-9136","authenticated-orcid":false,"given":"Eun Soo","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Kyungpook National University , Daegu, 41944,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School , Gwanju, 61469,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Chosun University Hospital , Gwangju, 61452,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan Medical Center , Seoul, 05505,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Kyungpook National University , Daegu, 41944,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Kook","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Kyungpook National University , Daegu, 41944,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School , Gwanju, 61469,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Chosun University Hospital , Gwangju, 61452,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong Ok","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Yeungnam University Hospital , Daegu, 42415,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Ik","family":"Jang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Yeungnam University Hospital , Daegu, 42415,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-0146","authenticated-orcid":false,"given":"Yoo Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Keimyung University School of Medicine , Daegu, 41931,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2428-1551","authenticated-orcid":false,"given":"Eun Mi","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Ewha Womans University Seoul Hospital , Seoul, 07804,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Konyang University Hospital , Daejeon, 35365,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Chi","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, 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