{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:17:39Z","timestamp":1788185859069,"version":"build-2803163510"},"reference-count":100,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The ileal pouch represents a unique adaptation of the ileum to serve the dual roles of nutrient absorption, fecal storage, and evacuation in a new luminal microenvironment. However, the adaptation process produces early histological inflammation and therefore clues in the development of pouchitis may lie in how the ileal pouch adapts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This narrative review explored anatomical and luminal ileal pouch adaptations, with a goal of designing clinical strategies that can strengthen the resilience of the pouch mucosa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive PubMed search was conducted, and findings were critically examined and summarized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Physiologically, the ileum must acquire key adaptive features, such as water and electrolyte reabsorption and distention capabilities to support optimal pouch function. However, other adaptations, such as severe villous blunting and alterations in bile acid metabolism, may accelerate an inflammatory environment. The benefits of retaining ileal type characteristics such as aspects of mucosal architecture are unclear, whereas changes in permeability and epithelial nutrient utilization remain incompletely characterized. Significant knowledge gaps remain regarding the optimal pouch microenvironment, including how the microbiome and its metabolites contribute to pouchitis development, and current therapies to manage pouchitis have yielded limited success. Mechanistically informed studies that explore the dynamic interplay between pouch structure, microbiota, and dietary influences are needed to better design targeted therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The ileal pouch undergoes a series of adaptations that are not fully understood. This review integrates current evidence to better understand these adaptations, highlights clinically relevant implications, and identifies key areas where further mechanistic investigation is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izag111","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:17:18Z","timestamp":1779794238000},"page":"1627-1639","source":"Crossref","is-referenced-by-count":1,"title":["Anatomical, physiological, and luminal adaptations occurring in an ileoanal pouch: opportunities for improving outcomes"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8096-6264","authenticated-orcid":false,"given":"Dakota","family":"Rhys-Jones","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, School of Translational Medicine, Monash University, and Alfred Health , Melbourne, 3004,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9108-1712","authenticated-orcid":false,"given":"Peter R","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Translational Medicine, Monash University, and Alfred Health , Melbourne, 3004,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6063-5118","authenticated-orcid":false,"given":"Emma P","family":"Halmos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Translational Medicine, Monash University, and Alfred Health , Melbourne, 3004,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P","family":"Segal","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Royal Melbourne Hospital , Melbourne, 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