{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:51:00Z","timestamp":1792612260939,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mucosal healing in ulcerative colitis (UC) is believed to follow a proximal-to-distal pattern. We evaluated colonic healing distribution in patients with moderate-to-severe UC receiving adalimumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients from the SERENE UC (Study of a Novel Approach to Induction and Maintenance Dosing with Adalimumab in Patients with Moderate to Severe Ulcerative Colitis) trial with full colonoscopies and segmental biopsies at screening, weeks 8, and 52 were included for endoscopic and histologic analyses if baseline Mayo endoscopic subscore (MES) or Robarts Histopathology Index (RHI) score, respectively, was &amp;gt;0 in the ascending, transverse, and\/or descending colon. Data were analyzed using a mixed model for repeated measures to account for clustering of segments within a patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Endoscopic and histologic analyses comprised 76 and 79 patients, respectively. Score reductions were significantly greater vs the rectum in the ascending (week 8: MES, mean \u22120.78 [95% confidence interval (CI), \u22121.03 to \u22120.52]; RHI, mean \u22124.70 [95% CI, \u22126.92 to \u22122.49]; week 52: MES, mean \u22120.63 [95% CI, \u22120.91 to \u22120.35]; RHI, mean \u22122.39 [95% CI, \u22124.64 to \u22120.15]), transverse (week 8: MES, mean \u22120.69 [95% CI, \u22120.94 to \u22120.43]; RHI, mean \u22123.57 [95% CI, \u22125.62 to \u22121.51]; week 52: MES, mean \u22120.64 [95% CI, \u22120.89 to \u22120.38]; RHI, mean \u22122.88 [95% CI, \u22124.99 to \u22120.77]), and descending colon (week 8: MES, mean \u22120.40 [95% CI, \u22120.67 to \u22120.13]; RHI, mean \u22122.55 [95% CI, \u22124.94 to \u22120.16]; week 52: MES, mean \u22120.52 [95% CI, \u22120.70 to \u22120.34]; RHI, mean \u22123.47 [95% CI, \u22125.37 to \u22121.56]). Endoscopic improvement\/remission and histologic remission were significantly more likely in the ascending and transverse colon than the rectum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings demonstrate that endoscopic and histologic healing is more challenging in the rectum compared with proximal colonic segments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izag184","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:30:59Z","timestamp":1792611059000},"source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic and histologic healing distribution and persistent rectosigmoiditis in moderate-to-severe ulcerative colitis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4698-9948","authenticated-orcid":false,"given":"Christopher","family":"Ma","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary , Calgary, Alberta,","place":["Canada"]},{"name":"Department of Community Health Sciences, Cumming School of Medicine, University of Calgary , Calgary, Alberta,","place":["Canada"]},{"name":"Medical Research and Development, Alimentiv Inc. , London, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurij","family":"Hanzel","sequence":"additional","affiliation":[{"name":"Medical Research and Development, Alimentiv Inc. , London, Ontario,","place":["Canada"]},{"name":"Department of Gastroenterology, Faculty of Medicine, University of Ljubljana , Ljubljana,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Sedano","sequence":"additional","affiliation":[{"name":"Medical Research and Development, Alimentiv Inc. , London, Ontario,","place":["Canada"]},{"name":"Division of Gastroenterology, Department of Medicine, Western University , London, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F Stephen","family":"Laroux","sequence":"additional","affiliation":[{"name":"Precision Medicine - Immunology, AbbVie Bioresearch Center , Waltham, Massachusetts,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, University of Ljubljana , Ljubljana,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4740-8209","authenticated-orcid":false,"given":"Brian","family":"Bressler","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, St. Paul\u2019s Hospital , Vancouver, British Columbia,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Dong","sequence":"additional","affiliation":[{"name":"Medical Research and Development, Alimentiv Inc. , London, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyong","family":"Zou","sequence":"additional","affiliation":[{"name":"Medical Research and Development, Alimentiv Inc. , London, Ontario,","place":["Canada"]},{"name":"Department of Epidemiology and Biostatistics, Western University , London, Ontario,","place":["Canada"]},{"name":"Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University , London, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie C","family":"McFarlane","sequence":"additional","affiliation":[{"name":"Medical Research and Development, Alimentiv Inc. , London, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N","family":"Bernstein","sequence":"additional","affiliation":[{"name":"IBD Clinical and Research Centre, Department of Internal Medicine, University of Manitoba , Winnipeg, Manitoba,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Narula","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rish K","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Sinai Health System , Toronto, Ontario,","place":["Canada"]},{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto , Toronto, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F","family":"Schaeffer","sequence":"additional","affiliation":[{"name":"Division of Anatomical Pathology, Vancouver General Hospital, University of British Columbia , Vancouver, British Columbia,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5247-940X","authenticated-orcid":false,"given":"Remo","family":"Panaccione","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary , Calgary, Alberta,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5762-5042","authenticated-orcid":false,"given":"Bruce E","family":"Sands","sequence":"additional","affiliation":[{"name":"Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai , New York, New York,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian G","family":"Feagan","sequence":"additional","affiliation":[{"name":"Medical Research and Development, Alimentiv Inc. , London, Ontario,","place":["Canada"]},{"name":"Division of Gastroenterology, Department of Medicine, Western University , London, Ontario,","place":["Canada"]},{"name":"Department of Epidemiology and Biostatistics, Western University , London, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-0033","authenticated-orcid":false,"given":"Vipul","family":"Jairath","sequence":"additional","affiliation":[{"name":"Medical Research and Development, Alimentiv Inc. , London, Ontario,","place":["Canada"]},{"name":"Division of Gastroenterology, Department of Medicine, Western University , London, 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