{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:52:33Z","timestamp":1791978753676,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013958","name":"Telemark Hospital Trust","doi-asserted-by":"publisher","award":["3092.03"],"award-info":[{"award-number":["3092.03"]}],"id":[{"id":"10.13039\/501100013958","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Takeda Pharmaceuticals, Pfizer"},{"DOI":"10.13039\/501100003122","name":"Ferring Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012276","name":"Tillotts Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012276","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Dam Foundation","id":[{"id":"https:\/\/ror.org\/00ky8w108","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the South-Eastern Health Authorities","id":[{"id":"https:\/\/ror.org\/00vyyx863","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence for the clinical importance of changes in health-related quality of life (HRQoL) over time in unselected patients with ulcerative colitis (UC) and Crohn\u2019s disease (CD) is limited. We aimed to describe HRQoL trajectories, determine clinically meaningful HRQoL improvement, and identify factors associated with such improvement during the first 3 years after diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults with UC and CD from a population-based inception cohort completed the Inflammatory Bowel Disease Questionnaire (IBDQ) and the 36-Item Short Form Survey (SF-36) at inclusion and at the 1-year and 3-year follow-ups. HRQoL trajectories were estimated using linear mixed-effects models. Clinically meaningful improvement was defined using established minimal clinically important difference (MCID) thresholds (IBDQ \u226516; SF-36 physical and mental component summary scores \u22653). Associations between prespecified variables and MCID achievement at follow-up were assessed using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1016 patients (UC: 68%; CD: 32%), IBDQ and SF-36 physical and mental component summary scores improved at both follow-ups, and approximately half of the patients achieved the corresponding MCID thresholds. HRQoL scores remained below general Norwegian population norms, and trajectories were similar for UC and CD. Symptomatic remission was consistently associated with higher odds of clinically meaningful HRQoL improvement, whereas depressive symptoms, substantial fatigue, and irritable bowel\u2013like symptoms were associated with lower odds. Endoscopic remission, biologic therapy, and bowel surgery during the first year were not significantly associated with clinically meaningful improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinically meaningful HRQoL improvement was achieved by about half of the patients and was consistently associated with lower symptom and psychosocial burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izag196","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:41:44Z","timestamp":1790077304000},"source":"Crossref","is-referenced-by-count":0,"title":["Health-related quality of life after diagnosis of ulcerative colitis and Crohn\u2019s disease: 3-year trajectories and factors associated with clinically meaningful improvement (the IBSEN III cohort)"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2926-753X","authenticated-orcid":false,"given":"Bjorn Christian","family":"Olsen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Telemark Hospital Trust , Skien,","place":["Norway"]},{"name":"Institute of Clinical Medicine, University of Oslo , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8947-8649","authenticated-orcid":false,"given":"Milada","family":"Hagen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , Oslo,","place":["Norway"]},{"name":"Department of Public Health, Oslo Metropolitan University , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0513-1435","authenticated-orcid":false,"given":"Randi","family":"Opheim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Oslo University Hospital , Oslo,","place":["Norway"]},{"name":"Institute of Health and Society, Department of Public Health, University of Oslo , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0876-8634","authenticated-orcid":false,"given":"Vendel A","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , Oslo,","place":["Norway"]},{"name":"Department of Gastroenterology, Oslo University Hospital , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5348-4645","authenticated-orcid":false,"given":"Charlotte","family":"Lund","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , Oslo,","place":["Norway"]},{"name":"Department of Gastroenterology, Oslo University Hospital , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4933-5580","authenticated-orcid":false,"given":"Tone B","family":"Aabrekk","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , Oslo,","place":["Norway"]},{"name":"Department of Gastroenterology, Vestfold Hospital Trust , T\u00f8nsberg,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2371-5036","authenticated-orcid":false,"given":"Ingunn","family":"Johansen","sequence":"additional","affiliation":[{"name":"Institute of Health and Society, Department of Public Health, University of Oslo , Oslo,","place":["Norway"]},{"name":"Department of Nursing, Health and Laboratory Science, Faculty of Health, Welfare and Organisation, \u00d8stfold University College , Fredrikstad,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4041-2623","authenticated-orcid":false,"given":"Kristina I Aass","family":"Holten","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , Oslo,","place":["Norway"]},{"name":"Department of Gastroenterology, \u00d8stfold Hospital Trust , Sarpsborg,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9121-6807","authenticated-orcid":false,"given":"Vibeke","family":"Strande","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , Oslo,","place":["Norway"]},{"name":"Unger\u2013Vetlesen Institute, Lovisenberg Diaconal Hospital , Oslo,","place":["Norway"]},{"name":"Department of Gastroenterology, Lovisenberg Diaconal Hospital , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5777-4719","authenticated-orcid":false,"given":"Ida Frivold","family":"Glad","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , Oslo,","place":["Norway"]},{"name":"Department of Gastroenterology, Oslo University Hospital , Oslo,","place":["Norway"]},{"name":"Unger\u2013Vetlesen Institute, Lovisenberg Diaconal Hospital , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-7141","authenticated-orcid":false,"given":"May\u2013Bente","family":"Bengtson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Vestfold Hospital Trust , T\u00f8nsberg,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1576-5298","authenticated-orcid":false,"given":"Trond Espen","family":"Detlie","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Akershus University Hospital , L\u00f8renskog,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-5127","authenticated-orcid":false,"given":"Asle W","family":"Medhus","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , Oslo,","place":["Norway"]},{"name":"Department of Gastroenterology, Oslo University Hospital , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6534-0573","authenticated-orcid":false,"given":"Raziye","family":"Boyar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Diakonhjemmet Hospital , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9350-1717","authenticated-orcid":false,"given":"Roald","family":"Torp","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hamar Hospital, Innlandet Hospital Trust , Hamar,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-4995","authenticated-orcid":false,"given":"Simen","family":"Vatn","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , Oslo,","place":["Norway"]},{"name":"Department of Gastroenterology, Akershus University Hospital , L\u00f8renskog,","place":["Norway"]},{"name":"Department of Medicine, Innlandet Hospital Trust , Gj\u00f8vik,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7841-608X","authenticated-orcid":false,"given":"Svein Oskar","family":"Frigstad","sequence":"additional","affiliation":[{"name":"Department of Medicine, B\u00e6rum Hospital, Vestre Viken Hospital Trust , Gjettum,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9988-2271","authenticated-orcid":false,"given":"Tomm","family":"Bernklev","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5465-1576","authenticated-orcid":false,"given":"Lars-Petter","family":"Jelsness-J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Nursing, Health and Laboratory Science, Faculty of Health, Welfare and Organisation, \u00d8stfold University College , Fredrikstad,","place":["Norway"]},{"name":"Department of Gastroenterology, \u00d8stfold Hospital Trust , Sarpsborg,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-465X","authenticated-orcid":false,"given":"Marte Lie","family":"H\u00f8ivik","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , Oslo,","place":["Norway"]},{"name":"Department of Gastroenterology, Oslo University Hospital , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5693-8773","authenticated-orcid":false,"given":"Gert","family":"Huppertz-Hauss","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Telemark Hospital Trust , Skien,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"2026101407304693500_izag196-B1","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1093\/ibd\/izx100","article-title":"Quality of life in inflammatory bowel disease: a systematic review and meta-analyses-part I","volume":"24","author":"Knowles","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"2026101407304693500_izag196-B2","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1093\/ibd\/izy015","article-title":"Quality of life in inflammatory bowel disease: a systematic review and meta-analyses-part II","volume":"24","author":"Knowles","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"2026101407304693500_izag196-B3","doi-asserted-by":"publisher","first-page":"253","DOI":"10.5009\/gnl240146","article-title":"Anxiety and depression are associated with poor long-term quality of life in moderate-to-severe ulcerative colitis: results of a 3-year longitudinal study of the Mosaik cohort","volume":"19","author":"Oh","year":"2025","journal-title":"Gut Liver"},{"key":"2026101407304693500_izag196-B4","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1093\/ecco-jcc\/jjv091","article-title":"Fatigue in newly diagnosed inflammatory bowel disease","volume":"9","author":"Grimstad","year":"2015","journal-title":"J Crohns Colitis"},{"key":"2026101407304693500_izag196-B5","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"STRIDE-II: an update on the selecting therapeutic targets in inflammatory bowel disease (STRIDE) initiative of the international organization for the study of IBD (IOIBD): determining therapeutic goals for Treat-to-Target strategies in IBD","volume":"160","author":"Turner","year":"2021","journal-title":"Gastroenterology"},{"key":"2026101407304693500_izag196-B6","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1111\/j.1365-2036.2009.03966.x","article-title":"Evaluation of the meaningfulness of health-related quality of life improvements as assessed by the SF-36 and the EQ-5D VAS in patients with active Crohn\u2019s disease","volume":"29","author":"Coteur","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"2026101407304693500_izag196-B7","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/j.crohns.2014.01.028","article-title":"Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with inflammatory bowel disease\u2014an ECCO-EpiCom study","volume":"8","author":"Burisch","year":"2014","journal-title":"J Crohns Colitis"},{"key":"2026101407304693500_izag196-B8","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1080\/00365521.2021.1922746","article-title":"Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway","volume":"56","author":"Kristensen","year":"2021","journal-title":"Scand J Gastroenterol"},{"key":"2026101407304693500_izag196-B9","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.1007\/s11136-023-03435-9","article-title":"Health-related quality of life in patients with newly diagnosed inflammatory bowel disease: an observational prospective cohort study (IBSEN III)","volume":"32","author":"Olsen","year":"2023","journal-title":"Qual Life Res"},{"key":"2026101407304693500_izag196-B10","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/00042737-199704000-00007","article-title":"Clinical uniformity of inflammatory bowel disease a presentation and during the first year of disease in the north and south of Europe. EC-IBD Study Group","volume":"9","author":"Lennard-Jones","year":"1997","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2026101407304693500_izag196-B11","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1177\/14034948980260040401","article-title":"Short form 36 (SF-36) health survey: normative data from the general Norwegian population","volume":"26","author":"H\u00c5vard Loge","year":"1998","journal-title":"Scand J Soc Med"},{"key":"2026101407304693500_izag196-B12","volume-title":"SF-36 Health Survey: Manual and Interpretation Guide","author":"Ware","year":"1993"},{"key":"2026101407304693500_izag196-B13","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1477-7525-5-54","article-title":"Correlated physical and mental health summary scores for the SF-36 and SF-12 Health Survey, V.I","volume":"5","author":"Farivar","year":"2007","journal-title":"Health Qual Life Outcomes"},{"key":"2026101407304693500_izag196-B14","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.2106\/jbjs.o.00030","article-title":"Scoring the SF-36 in orthopaedics: a brief guide","volume":"97","author":"Laucis","year":"2015","journal-title":"J Bone Joint Surg Am"},{"key":"2026101407304693500_izag196-B15","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1080\/003655202760373371","article-title":"Quality of life in patients with inflammatory bowel disease: translation, data quality, scaling assumptions, validity, reliability and sensitivity to change of the Norwegian version of IBDQ","volume":"37","author":"Bernklev","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"2026101407304693500_izag196-B16","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/S0016-5085(89)80080-0","article-title":"A new measure of health status for clinical trials in inflammatory bowel disease","volume":"96","author":"Guyatt","year":"1989","journal-title":"Gastroenterology"},{"key":"2026101407304693500_izag196-B17","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jclinepi.2016.11.016","article-title":"The minimal clinically important difference raised the significance of outcome effects above the statistical level, with methodological implications for future studies","volume":"82","author":"Angst","year":"2017","journal-title":"J Clin Epidemiol"},{"key":"2026101407304693500_izag196-B18","doi-asserted-by":"publisher","first-page":"CD008655","DOI":"10.1002\/14651858.CD008655.pub3","article-title":"The impact of biological interventions for ulcerative colitis on health-related quality of life","volume":"2015","author":"LeBlanc","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2026101407304693500_izag196-B19","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1002\/ibd.20301","article-title":"Quality of life of patients with ulcerative colitis: past, present, and future","volume":"14","author":"Irvine","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"2026101407304693500_izag196-B20","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1056\/nejmoa050516","article-title":"Infliximab for induction and maintenance therapy for ulcerative colitis","volume":"353","author":"Rutgeerts","year":"2005","journal-title":"N Engl J Med"},{"key":"2026101407304693500_izag196-B21","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988","edition":"2nd ed"},{"key":"2026101407304693500_izag196-B22","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/s0140-6736(80)92767-1","article-title":"A simple index of Crohn\u2019s-disease activity","volume":"1","author":"Harvey","year":"1980","journal-title":"Lancet"},{"key":"2026101407304693500_izag196-B23","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/gut.43.1.29","article-title":"A simple clinical colitis activity index","volume":"43","author":"Walmsley","year":"1998","journal-title":"Gut"},{"key":"2026101407304693500_izag196-B24","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1097\/01.mib.0000215091.77492.2a","article-title":"Predicting the Crohn\u2019s disease activity index from the Harvey-Bradshaw index","volume":"12","author":"Best","year":"2006","journal-title":"Inflamm Bowel Dis"},{"key":"2026101407304693500_izag196-B25","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1136\/gut.2004.056358","article-title":"Patient defined dichotomous end points for remission and clinical improvement in ulcerative colitis","volume":"54","author":"Higgins","year":"2005","journal-title":"Gut"},{"key":"2026101407304693500_izag196-B26","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/s0016-5107(04)01878-4","article-title":"Development and validation of a new, simplified endoscopic activity score for Crohn\u2019s disease: the SES-CD","volume":"60","author":"Daperno","year":"2004","journal-title":"Gastrointest Endosc"},{"key":"2026101407304693500_izag196-B27","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1056\/nejm198712243172603","article-title":"Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study","volume":"317","author":"Schroeder","year":"1987","journal-title":"N Engl J Med"},{"key":"2026101407304693500_izag196-B28","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1002\/ibd.22917","article-title":"Fecal calprotectin is a surrogate marker for endoscopic lesions in inflammatory bowel disease","volume":"18","author":"D\u2019Haens","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"2026101407304693500_izag196-B29","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1097\/MIB.0000000000001082","article-title":"Clinical utility of fecal calprotectin monitoring in asymptomatic patients with inflammatory bowel disease: a systematic review and practical guide","volume":"23","author":"Heida","year":"2017","journal-title":"Inflamm Bowel Dis"},{"key":"2026101407304693500_izag196-B30","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1093\/ecco-jcc\/jjy113","article-title":"ECCO-ESGAR guideline for diagnostic assessment in IBD Part 1: initial diagnosis, monitoring of known IBD, detection of complications","volume":"13","author":"Maaser","year":"2019","journal-title":"J Crohns Colitis"},{"key":"2026101407304693500_izag196-B31","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1093\/ecco-jcc\/jju009","article-title":"European consensus on the diagnosis and management of iron deficiency and anaemia in inflammatory bowel diseases","volume":"9","author":"Dignass","year":"2015","journal-title":"J Crohns Colitis"},{"key":"2026101407304693500_izag196-B32","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1053\/j.gastro.2016.02.014","article-title":"Development and validation of the Rome IV diagnostic questionnaire for adults","volume":"150","author":"Palsson","year":"2016","journal-title":"Gastroenterology"},{"key":"2026101407304693500_izag196-B33","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"2026101407304693500_izag196-B34","first-page":"35","volume-title":"Measures in Health Psychology: A User\u2019s Portfolio. Causal and Control Beliefs","author":"Schwarzer","year":"1995"},{"key":"2026101407304693500_izag196-B35","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/0022-3999(93)90081-P","article-title":"Development of a fatigue scale","volume":"37","author":"Chalder","year":"1993","journal-title":"J Psychosom Res"},{"key":"2026101407304693500_izag196-B36","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.3758\/s13428-012-0196-y","article-title":"Using the linear mixed model to analyze nonnormal data distributions in longitudinal designs","volume":"44","author":"Arnau","year":"2012","journal-title":"Behav Res Methods"},{"key":"2026101407304693500_izag196-B37","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jclinepi.2013.10.009","article-title":"The minimal clinically important difference determined using item response theory models: an attempt to solve the issue of the association with baseline score","volume":"67","author":"Rouquette","year":"2014","journal-title":"J Clin Epidemiol"},{"key":"2026101407304693500_izag196-B38","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1093\/ecco-jcc\/jjab161","article-title":"Association between proposed definitions of clinical remission\/response and well-being in patients with Crohn\u2019s disease","volume":"16","author":"Sandborn","year":"2022","journal-title":"J Crohns Colitis"},{"key":"2026101407304693500_izag196-B39","doi-asserted-by":"publisher","first-page":"jjaf132","DOI":"10.1093\/ecco-jcc\/jjaf132","article-title":"Patient-reported outcome measures poorly correlate with objective inflammatory bowel disease activity measures: a systematic review","volume":"19","author":"Calvet","year":"2025","journal-title":"J Crohns Colitis"},{"key":"2026101407304693500_izag196-B40","doi-asserted-by":"publisher","first-page":"e00577","DOI":"10.14309\/ctg.0000000000000577","article-title":"Self-efficacy and the impact of inflammatory bowel disease on patients\u2019 daily lives","volume":"14","author":"Sheehan","year":"2023","journal-title":"Clin Transl Gastroenterol"}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ibdjournal\/advance-article-pdf\/doi\/10.1093\/ibd\/izag196\/71943206\/izag196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/advance-article-pdf\/doi\/10.1093\/ibd\/izag196\/71943206\/izag196.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:32:14Z","timestamp":1791977534000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/advance-article\/doi\/10.1093\/ibd\/izag196\/8916309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":40,"URL":"https:\/\/doi.org\/10.1093\/ibd\/izag196","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"article-number":"izag196"}}