{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:36:41Z","timestamp":1784860601112,"version":"3.55.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T00:00:00Z","timestamp":1524528000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,23]]},"DOI":"10.1093\/ibd\/izy022","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T20:55:04Z","timestamp":1524516904000},"page":"1035-1044","source":"Crossref","is-referenced-by-count":60,"title":["Detection of Gut Dysbiosis due to Reduced Clostridium Subcluster XIVa Using the Fecal or Serum Bile Acid Profile"],"prefix":"10.1093","volume":"24","author":[{"given":"Masashi","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"},{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Tamamushi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadakuni","family":"Monma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichiro","family":"Yara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruo","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Joint Research Center, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Ikegami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,4,23]]},"reference":[{"key":"key\n\t\t\t\t20180508120045_CIT0001","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1136\/gutjnl-2011-301805","article-title":"A metagenomic insight into our gut\u2019s microbiome","volume":"62","author":"Lepage","year":"2013","journal-title":"Gut"},{"key":"key\n\t\t\t\t20180508120045_CIT0002","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature09646","article-title":"Bifidobacteria can protect from enteropathogenic infection through production of acetate","volume":"469","author":"Fukuda","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180508120045_CIT0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00281-014-0472-2","article-title":"Impact of commensal microbiota on the host pathophysiology: focusing on immunity and inflammation","volume":"37","author":"Ohno","year":"2015","journal-title":"Semin Immunopathol"},{"key":"key\n\t\t\t\t20180508120045_CIT0004","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180508120045_CIT0005","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/ncomms2266","article-title":"Symptomatic atherosclerosis is associated with an altered gut metagenome","volume":"3","author":"Karlsson","year":"2012","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t20180508120045_CIT0006","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","article-title":"Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk","volume":"368","author":"Tang","year":"2013","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180508120045_CIT0007","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature07540","article-title":"A core gut microbiome in obese and lean twins","volume":"457","author":"Turnbaugh","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180508120045_CIT0008","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/nm.4176","article-title":"Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation","volume":"22","author":"Fujimura","year":"2016","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20180508120045_CIT0009","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.cell.2013.11.024","article-title":"Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders","volume":"155","author":"Hsiao","year":"2013","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180508120045_CIT0010","doi-asserted-by":"crossref","first-page":"e0137429","DOI":"10.1371\/journal.pone.0137429","article-title":"Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to clostridia XIVa and IV clusters","volume":"10","author":"Miyake","year":"2015","journal-title":"Plos One"},{"key":"key\n\t\t\t\t20180508120045_CIT0011","doi-asserted-by":"crossref","first-page":"e0142164","DOI":"10.1371\/journal.pone.0142164","article-title":"Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in parkinson\u2019s disease","volume":"10","author":"Hasegawa","year":"2015","journal-title":"Plos One"},{"key":"key\n\t\t\t\t20180508120045_CIT0012","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/hep.26319","article-title":"Intestinal microbiota in patients with nonalcoholic fatty liver disease","volume":"58","author":"Mouzaki","year":"2013","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20180508120045_CIT0013","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/hep.28356","article-title":"The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota","volume":"63","author":"Boursier","year":"2016","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20180508120045_CIT0014","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature12347","article-title":"Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome","volume":"499","author":"Yoshimoto","year":"2013","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180508120045_CIT0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00281-014-0454-4","article-title":"The gut microbiota and inflammatory bowel disease","volume":"37","author":"Matsuoka","year":"2015","journal-title":"Semin Immunopathol"},{"key":"key\n\t\t\t\t20180508120045_CIT0016","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1136\/gutjnl-2012-303954","article-title":"Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome","volume":"62","author":"Knights","year":"2013","journal-title":"Gut"},{"key":"key\n\t\t\t\t20180508120045_CIT0017","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2036.2008.03860.x","article-title":"Faecal microbiota profile of Crohn\u2019s disease determined by terminal restriction fragment length polymorphism analysis","volume":"29","author":"Andoh","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t20180508120045_CIT0018","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/gut.2010.223263","article-title":"Dysbiosis of the faecal microbiota in patients with Crohn\u2019s disease and their unaffected relatives","volume":"60","author":"Joossens","year":"2011","journal-title":"Gut"},{"key":"key\n\t\t\t\t20180508120045_CIT0019","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1007\/s10620-012-2236-y","article-title":"Reduced diversity and imbalance of fecal microbiota in patients with ulcerative colitis","volume":"57","author":"Nemoto","year":"2012","journal-title":"Dig Dis Sci"},{"key":"key\n\t\t\t\t20180508120045_CIT0020","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1053\/j.gastro.2015.03.045","article-title":"Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis","volume":"149","author":"Rossen","year":"2015","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20180508120045_CIT0021","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/j.gastro.2007.04.005","article-title":"The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects","volume":"133","author":"Kassinen","year":"2007","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20180508120045_CIT0022","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease","volume":"375","author":"Lynch","year":"2016","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180508120045_CIT0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/jb.176.1.1-6.1994","article-title":"The winds of (evolutionary) change: breathing new life into microbiology","volume":"176","author":"Olsen","year":"1994","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180508120045_CIT0024","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","article-title":"Bile salt biotransformations by human intestinal bacteria","volume":"47","author":"Ridlon","year":"2006","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t20180508120045_CIT0025","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1099\/00207713-44-4-812","article-title":"The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species combinations","volume":"44","author":"Collins","year":"1994","journal-title":"Int J Syst Bacteriol"},{"key":"key\n\t\t\t\t20180508120045_CIT0026","doi-asserted-by":"crossref","first-page":"e105592","DOI":"10.1371\/journal.pone.0105592","article-title":"Development of a prokaryotic universal primer for simultaneous analysis of bacteria and archaea using next-generation sequencing","volume":"9","author":"Takahashi","year":"2014","journal-title":"Plos One"},{"key":"key\n\t\t\t\t20180508120045_CIT0027","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1128\/AEM.69.2.1251-1262.2003","article-title":"Application of new primer-enzyme combinations to terminal restriction fragment length polymorphism profiling of bacterial populations in humans feces","volume":"69","author":"Nagashima","year":"2003","journal-title":"Appl Environ Microbiol"},{"key":"key\n\t\t\t\t20180508120045_CIT0028","doi-asserted-by":"crossref","first-page":"99","DOI":"10.12938\/bifidus.25.99","article-title":"Phylogenetic analysis of 16S ribosomal RNA gene sequences from human fecal microbiota and improved utility of terminal restriction fragment length polymorphism profiling","volume":"25","author":"Nagashima","year":"2006","journal-title":"Biosci Microflora"},{"key":"key\n\t\t\t\t20180508120045_CIT0029","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0022-2275(20)38479-0","article-title":"Similarity of unusual bile acids in human umbilical cord blood and amniotic fluid from newborns and in sera and urine from adult patients with cholestatic liver diseases","volume":"29","author":"Shoda","year":"1988","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t20180508120045_CIT0030","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.jpba.2005.09.013","article-title":"High sensitive analysis of rat serum bile acids by liquid chromatography\/electrospray ionization tandem mass spectrometry","volume":"40","author":"Ando","year":"2006","journal-title":"J Pharm Biomed Anal"},{"key":"key\n\t\t\t\t20180508120045_CIT0031","doi-asserted-by":"crossref","first-page":"99","DOI":"10.12938\/bmfh.33.99","article-title":"Establishment of intestinal bacteriology","volume":"33","author":"Mitsuoka","year":"2014","journal-title":"Biosci Microbiota Food Health"},{"key":"key\n\t\t\t\t20180508120045_CIT0032","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0022-2275(20)37944-X","article-title":"Degradation of steroids in the human gut","volume":"24","author":"Macdonald","year":"1983","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t20180508120045_CIT0033","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0022-2275(20)40615-7","article-title":"7alpha-dehydroxylation of cholic acid and chenodeoxycholic acid by clostridium leptum","volume":"20","author":"Stellwag","year":"1979","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t20180508120045_CIT0034","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1099\/00207713-51-1-39","article-title":"Clostridium hiranonis sp. nov., a human intestinal bacterium with bile acid 7\u03b1-dehydroxylating activity","volume":"51","author":"Kitahara","year":"2001","journal-title":"Int J Syst Evol Microbiol"},{"key":"key\n\t\t\t\t20180508120045_CIT0035","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1099\/00207713-50-3-971","article-title":"Assignment of Eubacterium sp. VPI 12708 and related strains with high bile acid 7\u03b1-dehydroxylating activity to Clostridium scindens and proposal of Clostridium hylemonae sp. nov., isolated from human feces","volume":"50","author":"Kitahara","year":"2000","journal-title":"Int J Syst Evol Microbiol"},{"key":"key\n\t\t\t\t20180508120045_CIT0036","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4161\/gmic.25723","article-title":"Cirrhosis, bile acids and gut microbiota: unraveling a complex relationship","volume":"4","author":"Ridlon","year":"2013","journal-title":"Gut Microbes"},{"key":"key\n\t\t\t\t20180508120045_CIT0037","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1194\/jlr.M039834","article-title":"Contribution of the 7\u03b2-hydroxysteroid dehydrogenase from1 ruminococcus gnavus N53 to ursodeoxycholic acid formation in the human colon","volume":"54","author":"Lee","year":"2013","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t20180508120045_CIT0038","doi-asserted-by":"crossref","first-page":"e90981","DOI":"10.1371\/journal.pone.0090981","article-title":"Fecal microbial composition of ulcerative colitis and Crohn\u2019s disease patients in remission and subsequent exacerbation","volume":"9","author":"Wills","year":"2014","journal-title":"Plos One"},{"key":"key\n\t\t\t\t20180508120045_CIT0039","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1128\/JB.188.5.1979-1986.2006","article-title":"Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria","volume":"188","author":"Kurdi","year":"2006","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180508120045_CIT0040","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nature13828","article-title":"Precision microbiome reconstitution restores bile acid mediated resistance to clostridium difficile","volume":"517","author":"Buffie","year":"2015","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180508120045_CIT0041","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180508120045_CIT0042","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1198469","article-title":"Induction of colonic regulatory T cells by indigenous clostridium species","volume":"331","author":"Atarashi","year":"2011","journal-title":"Science"},{"key":"key\n\t\t\t\t20180508120045_CIT0043","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1097\/MIB.0000000000000972","article-title":"A single species of clostridium subcluster XIVa decreased in ulcerative colitis patients","volume":"22","author":"Takeshita","year":"2016","journal-title":"Inflamm Bowel Dis"},{"key":"key\n\t\t\t\t20180508120045_CIT0044","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jhep.2013.01.003","article-title":"Modulation of the fecal bile acid profile by gut microbiota in cirrhosis","volume":"58","author":"Kakiyama","year":"2013","journal-title":"J Hepatol"},{"key":"key\n\t\t\t\t20180508120045_CIT0045","doi-asserted-by":"crossref","first-page":"455","DOI":"10.4161\/gmic.21216","article-title":"Is bile acid a determinant of the gut microbiota on a high-fat diet","volume":"3","author":"Yokota","year":"2012","journal-title":"Gut Microbes"},{"key":"key\n\t\t\t\t20180508120045_CIT0046","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180508120045_CIT0047","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/19490976.2016.1150414","article-title":"Taurocholic acid metabolism by gut microbes and colon cancer","volume":"7","author":"Ridlon","year":"2016","journal-title":"Gut Microbes"}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ibdjournal\/article-pdf\/24\/5\/1035\/24798269\/izy022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T19:41:33Z","timestamp":1661024493000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/24\/5\/1035\/4982877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,23]]},"references-count":47,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,4,23]]},"published-print":{"date-parts":[[2018,4,23]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izy022","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,5]]},"published":{"date-parts":[[2018,4,23]]}}}