{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:34:02Z","timestamp":1789569242796,"version":"build-2803163510"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Clinical and Translational Science Award","award":["UL1 TR000448"],"award-info":[{"award-number":["UL1 TR000448"]}]},{"name":"Siteman Comprehensive Cancer Center and NCI Cancer Center","award":["P30 CA091842"],"award-info":[{"award-number":["P30 CA091842"]}]},{"name":"WUSM DDRCC","award":["P30 DK052574"],"award-info":[{"award-number":["P30 DK052574"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Inflammation of the pouch after ileal pouch-anal anastomosis (IPAA) can significantly impact quality of life and be difficult to treat. We assessed the effectiveness and safety of vedolizumab in Crohn\u2019s disease (CD) of the pouch and chronic antibiotic-dependent or antibiotic-refractory pouchitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective, multicenter cohort study at 5 academic referral centers in the United States. Adult patients with endoscopic inflammation of the pouch who received vedolizumab were included. The primary outcome was clinical response at any time point. Secondary outcomes included clinical remission, endoscopic response, and remission. Univariate analysis and multivariate analysis were performed for the effect of the following variables on clinical response: fistula, onset of pouchitis less than 1 year after IPAA, younger than 35 years old, gender, previous tumor necrosis factor inhibitor-alpha use, and BMI &amp;gt;30.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty-three patients were treated with vedolizumab for inflammation of the pouch between January 2014 and October 2017. Median follow-up was 1.3 years (interquartile range 0.7\u20132.1). The proportion of patients that achieved at least a clinical response was 71.1%, with 19.3% achieving clinical remission. Of the 74 patients with a follow-up pouchoscopy, the proportion of patients with endoscopic response and mucosal healing was 54.1% and 17.6%, respectively. Patients who developed pouchitis symptoms less than 1 year after undergoing IPAA were less likely to respond to vedolizumab, even after controlling for other risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vedolizumab is safe and effective in the management of CD of the pouch and chronic pouchitis. Further studies are needed to compare vedolizumab with other biologic therapies for pouchitis and CD of the pouch.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izz030","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T10:45:06Z","timestamp":1551264306000},"page":"1569-1576","source":"Crossref","is-referenced-by-count":74,"title":["Efficacy of Vedolizumab for Refractory Pouchitis of the Ileo-anal Pouch: Results From a Multicenter US Cohort"],"prefix":"10.1093","volume":"25","author":[{"given":"Martin","family":"Gregory","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly N","family":"Weaver","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-8289","authenticated-orcid":false,"given":"Patrick","family":"Hoversten","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Bradley","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A","family":"Ciorba","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Washington University Inflammatory Bowel Diseases Center, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Washington University Inflammatory Bowel Diseases Center, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Beniwal-Patel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowmya","family":"Palam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Syal","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans H","family":"Herfarth","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"},{"name":"Multidisciplinary Center for Inflammatory Bowel Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"},{"name":"Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Christophi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Washington University Inflammatory Bowel Diseases Center, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Raffals","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L","family":"Barnes","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"},{"name":"Multidisciplinary Center for Inflammatory Bowel Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3436-9784","authenticated-orcid":false,"given":"Parakkal","family":"Deepak","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Washington University Inflammatory Bowel Diseases Center, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"2020010210475122000_CIT0001","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ibd.20278","article-title":"Outcome after proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis","volume":"14","author":"Ferrante","year":"2008","journal-title":"Inflamm Bowel Dis."},{"key":"2020010210475122000_CIT0002","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.cgh.2013.03.033","article-title":"Pouchitis: what every gastroenterologist needs to know","volume":"11","author":"Shen","year":"2013","journal-title":"Clin Gastroenterol 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Rectum."},{"key":"2020010210475122000_CIT0012","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1046\/j.1365-2036.2003.01535.x","article-title":"Infliximab in refractory pouchitis complicated by fistulae following ileo-anal pouch for ulcerative colitis","volume":"17","author":"Viscido","year":"2003","journal-title":"Aliment Pharmacol Ther."},{"key":"2020010210475122000_CIT0013","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1215739","article-title":"Vedolizumab as induction and maintenance therapy for Crohn\u2019s disease","volume":"369","author":"Sandborn","year":"2013","journal-title":"N Engl J Med."},{"key":"2020010210475122000_CIT0014","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/ecco-jcc\/jjv226","article-title":"Vedolizumab effectiveness and safety over the first year of use in an IBD clinical practice","volume":"10","author":"Vivio","year":"2016","journal-title":"J Crohns Colitis."},{"key":"2020010210475122000_CIT0015","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.1097\/MIB.0000000000000992","article-title":"Efficacy of vedolizumab in patients with antibiotic and anti-tumor necrosis alpha refractory pouchitis","volume":"23","author":"Philpott","year":"2017","journal-title":"Inflamm Bowel Dis."},{"key":"2020010210475122000_CIT0016","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1097\/MIB.0000000000000561","article-title":"Efficacy of vedolizumab as induction therapy in refractory IBD patients: a multicenter cohort","volume":"21","author":"Shelton","year":"2015","journal-title":"Inflamm Bowel Dis."},{"key":"2020010210475122000_CIT0017","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s00384-017-2854-0","article-title":"Successful treatment of chronic refractory pouchitis with vedolizumab","volume":"32","author":"Mir","year":"2017","journal-title":"Int J Colorectal 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