{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:13:24Z","timestamp":1785186804838,"version":"3.55.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There is often dissociation between inflammatory activity and abdominal pain in children with inflammatory bowel disease (IBD), suggesting other factors may play a role in the pain experience.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients (8 to 17 years) newly diagnosed with IBD were enrolled in the ALLAY Study: Assessing Risk Factors for Abdominal Pain in Children with Inflammatory Bowel Disease (NCT02984059). At diagnostic colonoscopy, 3 rectal biopsies were collected, and gene expression analysis was performed using Qiagen RT2 Profiler Neuropathic and Inflammatory Pain PCR Array. Relative fold difference in gene expression for 84 pain-associated genes was calculated using the 2-\u0394\u0394 Cq method compared with pain-free controls. Factors affecting pain burden (Pain Burden Interview; PBI) were analyzed, including age, sex, rectal inflammation, and gene expression. Data were analyzed using multiple stepwise linear regression and 2-tailed t tests (P \u2264 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thirty-nine newly diagnosed IBD patients were included (65% male, mean age 12.75 years [SD 2.63], 23 Crohn\u2019s disease, 16 ulcerative colitis), along with 3 controls. Mean PBI score was 7.73 (SD 6.4, range 0 to 23) for all patients. Age and sex were not predictive of pain burden, but disease activity score was (P = 0.03). Expression of TRPV3, OPRM1, P2X3, SCN9A, PTGS2, and MAPK14 were associated with PBI score. Subsequent 2-tailed t tests comparing patients with no pain (PBI score \u2266 2, N = 11) to those with pain (PBI &amp;gt; 2, N = 28) confirmed differential expression of TRPV3, PTGS2, and MAPK14 was in patients with pain (all P &amp;lt; 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pain burden in newly diagnosed IBD patients may be linked to TRPV3, PTGS2, and MAPK14 expression, suggesting potential therapeutic targets for managing pain in IBD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izz240","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T21:39:01Z","timestamp":1571434741000},"page":"1283-1290","source":"Crossref","is-referenced-by-count":13,"title":["Characterizing Clinical Features and Creating a Gene Expression Profile Associated With Pain Burden in Children With Inflammatory Bowel Disease"],"prefix":"10.1093","volume":"26","author":[{"given":"Victoria","family":"Grossi","sequence":"first","affiliation":[{"name":"Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children\u2019s Medical Center, Hartford, Connecticut, USA"},{"name":"Department of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S","family":"Hyams","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children\u2019s Medical Center, Hartford, Connecticut, USA"},{"name":"Department of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C","family":"Glidden","sequence":"additional","affiliation":[{"name":"Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany E","family":"Knight","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Kansas School of Medicine, Kansas City, Kansas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,18]]},"reference":[{"key":"2020071623423246100_CIT0001","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ibd.20848","article-title":"Pain and inflammatory bowel disease","volume":"15","author":"Bielefeldt","year":"2009","journal-title":"Inflamm Bowel 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