{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:45:47Z","timestamp":1788997547775,"version":"build-2803163510"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000226","name":"Ontario Ministry of Health and Long-Term Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000149","name":"Canadian Association of Gastroenterology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000066","name":"Canadian Child Health Clinician Scientist Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Originally used for screening of inborn errors of metabolism, routine metabolite profiles of newborns have also been associated with prematurity and some childhood diseases. We sought to determine whether metabolites measured during routine newborn screening could identify infants who develop inflammatory bowel disease (IBD) in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a population-based matched case-control study using health administrative data from Ontario, Canada. Children born 2006 to 2015 with IBD were identified using a validated algorithm and matched to 5 controls based on birth date, sex, rural\/urban household, and mean neighborhood income quintile at birth. Cases and controls were linked deterministically to metabolic profiles from Newborn Screening Ontario. We fit a lasso penalized logistic regression model and used 10-fold cross-validation to obtain internally valid performance measures. Models included metabolites, amino acids, and endocrine markers. Models also included ratios of metabolites, gestational age, birth weight, mode of delivery, age at serum collection, maternal age at delivery, maternal history of IBD, and parity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred eight cases of IBD, diagnosed at 5.5 \u00b1 2.8 years, were matched to 1540 controls. No individual metabolites were associated with IBD. The c-statistic was 0.50 for the training data. After 10-fold cross-validation the C statistic was 0.50, indicating no significant association between metabolites and IBD diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Newborn screening serum metabolites could not identify children who will develop IBD in this population-based cohort. Future studies with an expanded panel of metabolites may provide improved prediction of IBD.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ibd\/izz296","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T13:07:19Z","timestamp":1576156039000},"page":"1743-1747","source":"Crossref","is-referenced-by-count":6,"title":["Serum Newborn Screening Blood Metabolites Are not Associated With Childhood-onset Inflammatory Bowel Disease: A Population-based Matched Case-control Study"],"prefix":"10.1093","volume":"26","author":[{"given":"M Ellen","family":"Kuenzig","sequence":"first","affiliation":[{"name":"Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, Children\u2019s Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada"},{"name":"CHEO Research Institute, Ottawa, ON, Canada"},{"name":"ICES uOttawa, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Hawken","sequence":"additional","affiliation":[{"name":"ICES uOttawa, Ottawa, ON, Canada"},{"name":"Ottawa Hospital Research Institute, Ottawa, ON, Canada"},{"name":"Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada"},{"name":"Newborn Screening Ontario, Children\u2019s Hospital of Eastern Ontario, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumanan","family":"Wilson","sequence":"additional","affiliation":[{"name":"ICES uOttawa, Ottawa, ON, Canada"},{"name":"Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada"},{"name":"Department of Medicine, University of Ottawa, Ottawa, ON, Canada"},{"name":"Newborn Screening Ontario, Children\u2019s Hospital of Eastern Ontario, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Talarico","sequence":"additional","affiliation":[{"name":"ICES uOttawa, Ottawa, ON, Canada"},{"name":"Ottawa Hospital Research Institute, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranesh","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada"},{"name":"Newborn Screening Ontario, Children\u2019s Hospital of Eastern Ontario, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish M","family":"Sood","sequence":"additional","affiliation":[{"name":"ICES uOttawa, Ottawa, ON, Canada"},{"name":"Ottawa Hospital Research Institute, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8855-3598","authenticated-orcid":false,"given":"Eric I","family":"Benchimol","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, Children\u2019s Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada"},{"name":"CHEO Research Institute, Ottawa, ON, Canada"},{"name":"ICES uOttawa, Ottawa, ON, Canada"},{"name":"Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada"},{"name":"School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"key":"2020102313004686800_CIT0001","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/ajg.2017.97","article-title":"Trends in epidemiology of pediatric inflammatory bowel disease in Canada: distributed network analysis of multiple population-based provincial health administrative databases","volume":"112","author":"Benchimol","year":"2017","journal-title":"Am J Gastroenterol."},{"key":"2020102313004686800_CIT0002","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1097\/MIB.0000000000000103","article-title":"Changing age demographics of inflammatory bowel disease in Ontario, Canada: a population-based cohort study of epidemiology trends","volume":"20","author":"Benchimol","year":"2014","journal-title":"Inflamm Bowel Dis."},{"key":"2020102313004686800_CIT0003","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ebiom.2017.06.012","article-title":"The NOD2-smoking interaction in Crohn\u2019s disease is likely specific to the 1007fs mutation and may be explained by age at diagnosis: a meta-analysis and case-only study","volume":"21","author":"Kuenzig","year":"2017","journal-title":"Ebiomedicine."},{"key":"2020102313004686800_CIT0004","first-page":"1761","article-title":"The impact of inflammatory bowel disease in Canada 2018: children and adolescents with IBD","volume":"20","author":"Carroll","year":"2018","journal-title":"J Can Assoc Gastroenterol."},{"key":"2020102313004686800_CIT0005","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/ajg.2017.208","article-title":"Rural and urban residence during early life is associated with a lower risk of inflammatory bowel disease: a population-based inception and birth cohort study","volume":"112","author":"Benchimol","year":"2017","journal-title":"Am J Gastroenterol."},{"key":"2020102313004686800_CIT0006","author":"Newborn Screening Ontario"},{"key":"2020102313004686800_CIT0007","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ekir.2018.02.001","article-title":"Association between newborn metabolic profiles and pediatric kidney disease","volume":"3","author":"Sood","year":"2018","journal-title":"Kidney Int Rep."},{"key":"2020102313004686800_CIT0008","doi-asserted-by":"crossref","first-page":"18020","DOI":"10.1038\/s41598-017-18371-1","article-title":"Using newborn screening analytes to identify cases of neonatal sepsis","volume":"7","author":"Fell","year":"2017","journal-title":"Sci Rep."},{"key":"2020102313004686800_CIT0009","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/pr.2013.212","article-title":"Metabolomics of prematurity: analysis of patterns of amino acids, enzymes, and endocrine markers by categories of gestational age","volume":"75","author":"Wilson","year":"2014","journal-title":"Pediatr Res."},{"key":"2020102313004686800_CIT0010"},{"key":"2020102313004686800_CIT0011","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1136\/gut.2009.188383","article-title":"Increasing incidence of paediatric inflammatory bowel disease in Ontario, Canada: evidence from health administrative data","volume":"58","author":"Benchimol","year":"2009","journal-title":"Gut."},{"key":"2020102313004686800_CIT0012","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/BF03404588","article-title":"Socioeconomic misclassification in Ontario\u2019s Health Care Registry","volume":"94","author":"Glazier","year":"2003","journal-title":"Can J Public Health."},{"key":"2020102313004686800_CIT0013","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","article-title":"Regression shrinkage and selection via the lasso","volume":"58","author":"Tibshirani","year":"1996","journal-title":"J Royal Stat Soc."},{"key":"2020102313004686800_CIT0014","year":"2014"},{"key":"2020102313004686800_CIT0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J Stat Softw."},{"key":"2020102313004686800_CIT0016","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/00365521.2015.1105286","article-title":"Extending landscape of volatile metabolites as novel diagnostic biomarkers of inflammatory bowel disease - a review","volume":"51","author":"Ahmed","year":"2016","journal-title":"Scand J Gastroenterol."},{"key":"2020102313004686800_CIT0017","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2012-302717","article-title":"Serological markers predict inflammatory bowel disease years before the diagnosis","volume":"62","author":"van Schaik","year":"2013","journal-title":"Gut."},{"key":"2020102313004686800_CIT0018","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/ibd.21903","article-title":"Serological antibodies in inflammatory bowel disease: a systematic review","volume":"18","author":"Prideaux","year":"2012","journal-title":"Inflamm Bowel Dis."}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ibdjournal\/article-pdf\/26\/11\/1743\/33999642\/izz296.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ibdjournal\/article-pdf\/26\/11\/1743\/33999642\/izz296.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T14:10:57Z","timestamp":1722175857000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/26\/11\/1743\/5674034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,12]]},"references-count":18,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,12,12]]},"published-print":{"date-parts":[[2020,10,23]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izz296","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,11]]},"published":{"date-parts":[[2019,12,12]]}}}