{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:11:54Z","timestamp":1792213914613,"version":"4.4.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2017-02475"],"award-info":[{"award-number":["2017-02475"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001729","name":"Swedish Foundation For Strategic Research","doi-asserted-by":"crossref","award":["RB13-016"],"award-info":[{"award-number":["RB13-016"]}],"id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["PI16\/00583"],"award-info":[{"award-number":["PI16\/00583"]}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["CIBER-EHD CB06\/04\/0021"],"award-info":[{"award-number":["CIBER-EHD CB06\/04\/0021"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Barrier dysfunction is recognized as a pathogenic factor in ulcerative colitis (UC) and irritable bowel syndrome (IBS), but it is unclear to what extent the factors related to barrier dysfunction are disease-specific. The aim of this study was to compare these aspects in UC patients in remission, IBS patients, and healthy controls (HCs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Colonic biopsies were collected from 13 patients with UC in remission, 15 patients with IBS-mixed, and 15 HCs. Ulcerative colitis patients had recently been treated for relapse, and biopsies were taken from earlier inflamed areas. Biopsies were mounted in Ussing chambers for measurements of intestinal paracellular permeability to 51chromium (Cr)-ethylenediaminetetraacetic acid (EDTA). In addition, biopsies were analyzed for mast cells and eosinophils by histological procedures, and plasma tumor necrosis factor (TNF)-\u03b1 was assessed by ELISA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Ussing chamber experiments revealed an increased 51Cr-EDTA permeability in UC and IBS (P &amp;lt; 0.05). The 51Cr-EDTA permeability was higher in UC compared with IBS (P &amp;lt; 0.005). There were increased numbers of mucosal mast cells and eosinophils in UC and IBS and more eosinophils in UC compared with IBS (P &amp;lt; 0.05). Also, increased extracellular granule content was found in UC compared with HCs (P &amp;lt; 0.05). The 51Cr-EDTA permeability correlated significantly with eosinophils in all groups. Plasma TNF-\u03b1 concentration was higher in UC compared with IBS and HCs (P &amp;lt; 0.0005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Results indicate a more permeable intestinal epithelium in inactive UC and IBS compared with HCs. Ulcerative colitis patients, even during remission, demonstrate a leakier barrier compared with IBS. Both eosinophil numbers and activation state might be involved in the increased barrier function seen in UC patients in remission.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izz328","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T14:44:32Z","timestamp":1579185872000},"page":"974-984","source":"Crossref","is-referenced-by-count":54,"title":["Increased Colonic Epithelial Permeability and Mucosal Eosinophilia in Ulcerative Colitis in Remission Compared With Irritable Bowel Syndrome and Health"],"prefix":"10.1093","volume":"26","author":[{"given":"Georgios","family":"Katinios","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Linko\u0308ping University, Linko\u0308ping, Sweden"},{"name":"Department of Biomedical and Clinical Sciences, Linko\u0308ping University, Linko\u0308ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Casado-Bedmar","sequence":"first","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, Linko\u0308ping University, Linko\u0308ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna A","family":"Walter","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Linko\u0308ping University, Linko\u0308ping, Sweden"},{"name":"Department of Biomedical and Clinical Sciences, Linko\u0308ping University, Linko\u0308ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Vicario","sequence":"first","affiliation":[{"name":"Laboratory of Translational Mucosal Immunology, Digestive Diseases Research Unit. Vall d\u2019Hebron Institut de Recerca, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M","family":"Gonz\u00e1lez-Castro","sequence":"first","affiliation":[{"name":"Laboratory of Translational Mucosal Immunology, Digestive Diseases Research Unit. Vall d\u2019Hebron Institut de Recerca, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Bednarska","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Linko\u0308ping University, Linko\u0308ping, Sweden"},{"name":"Department of Biomedical and Clinical Sciences, Linko\u0308ping University, Linko\u0308ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan D","family":"S\u00f6derholm","sequence":"first","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, Linko\u0308ping University, Linko\u0308ping, Sweden"},{"name":"Department of Surgery, Link\u00f6ping, Linko\u0308ping University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hjortswang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Linko\u0308ping University, Linko\u0308ping, Sweden"},{"name":"Department of Biomedical and Clinical Sciences, Linko\u0308ping University, Linko\u0308ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa V","family":"Keita","sequence":"first","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, Linko\u0308ping University, Linko\u0308ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"2020061806434086600_CIT0001","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","article-title":"Bowel disorders","volume":"150","author":"Mearin","year":"2016","journal-title":"Gastroenterology."},{"key":"2020061806434086600_CIT0002","first-page":"151","article-title":"Small bowel and colonic permeability to 51Cr-EDTA in patients with active inflammatory bowel disease","volume":"11","author":"Jenkins","year":"1988","journal-title":"Clin Invest Med."},{"key":"2020061806434086600_CIT0003","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1097\/00006231-200109000-00009","article-title":"(51)CrEDTA colonic permeability and therapy response in patients with ulcerative colitis","volume":"22","author":"Arslan","year":"2001","journal-title":"Nucl Med Commun."},{"key":"2020061806434086600_CIT0004","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1136\/gut.38.6.864","article-title":"Assessing the site of increased intestinal permeability in coeliac and inflammatory bowel disease","volume":"38","author":"Teahon","year":"1996","journal-title":"Gut."},{"key":"2020061806434086600_CIT0005","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1053\/j.gastro.2017.06.051","article-title":"Vasoactive intestinal polypeptide and mast cells regulate increased passage of colonic bacteria in patients with irritable bowel syndrome","volume":"153","author":"Bednarska","year":"2017","journal-title":"Gastroenterology."},{"key":"2020061806434086600_CIT0006","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/j.1572-0241.2006.00672.x","article-title":"Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes","volume":"101","author":"Dunlop","year":"2006","journal-title":"Am J Gastroenterol."},{"key":"2020061806434086600_CIT0007","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/gut.2007.140806","article-title":"Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators","volume":"58","author":"Piche","year":"2009","journal-title":"Gut."},{"key":"2020061806434086600_CIT0008","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000333083","article-title":"Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis","volume":"85","author":"Gecse","year":"2012","journal-title":"Digestion."},{"key":"2020061806434086600_CIT0009","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1136\/gutjnl-2012-304066","article-title":"Functional bowel symptoms in quiescent inflammatory bowel diseases: role of epithelial barrier disruption and low-grade inflammation","volume":"63","author":"Vivinus-N\u00e9bot","year":"2014","journal-title":"Gut."},{"key":"2020061806434086600_CIT0010","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1097\/MIB.0000000000000921","article-title":"IBS-like symptoms in patients with ulcerative colitis in deep remission are associated with increased levels of serum cytokines and poor psychological well-being","volume":"22","author":"Jonefj\u00e4ll","year":"2016","journal-title":"Inflamm Bowel Dis."},{"key":"2020061806434086600_CIT0011","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/ajg.2009.116","article-title":"T-cell activation in patients with irritable bowel syndrome","volume":"104","author":"Ohman","year":"2009","journal-title":"Am J Gastroenterol."},{"key":"2020061806434086600_CIT0012","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/nmo.12811","article-title":"Expression of inducible nitric oxide synthase in mast cells contributes to the regulation of inflammatory cytokines in irritable bowel syndrome with diarrhea","volume":"28","author":"An","year":"2016","journal-title":"Neurogastroenterol Motil."},{"key":"2020061806434086600_CIT0013","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s10620-013-2930-4","article-title":"Colonic mucosal immune activity in irritable bowel syndrome: comparison with healthy controls and patients with ulcerative colitis","volume":"59","author":"Ahn","year":"2014","journal-title":"Dig Dis Sci."},{"key":"2020061806434086600_CIT0014","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbadis.2011.03.016","article-title":"Intestinal mast cells in gut inflammation and motility disturbances","volume":"1822","author":"De Winter","year":"2012","journal-title":"Biochim Biophys Acta."},{"key":"2020061806434086600_CIT0015","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3748\/wjg.v10.i3.309","article-title":"Key role of mast cells and their major secretory products in inflammatory bowel disease","volume":"10","author":"He","year":"2004","journal-title":"World J Gastroenterol."},{"key":"2020061806434086600_CIT0016","doi-asserted-by":"crossref","first-page":"e13503","DOI":"10.1111\/nmo.13503","article-title":"Upregulation of intestinal mucosal mast cells expressing VPAC1 in close proximity to vasoactive intestinal polypeptide in inflammatory bowel disease and murine colitis","volume":"31","author":"Casado-Bedmar","year":"2019","journal-title":"Neurogastroenterol Motil."},{"key":"2020061806434086600_CIT0017","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/gut.2006.100594","article-title":"Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum","volume":"56","author":"Guilarte","year":"2007","journal-title":"Gut."},{"key":"2020061806434086600_CIT0018","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/ajg.2008.94","article-title":"Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms","volume":"104","author":"Cremon","year":"2009","journal-title":"Am J Gastroenterol."},{"key":"2020061806434086600_CIT0019","doi-asserted-by":"crossref","first-page":"G1028","DOI":"10.1152\/ajpgi.00066.2003","article-title":"Human ENS regulates the intestinal epithelial barrier permeability and a tight junction-associated protein ZO-1 via VIPergic pathways","volume":"285","author":"Neunlist","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"2020061806434086600_CIT0020","first-page":"R362","article-title":"VIP, serotonin, and epinephrine modulate the ion selectivity of tight junctions of goldfish intestine","volume":"264","author":"Bakker","year":"1993","journal-title":"Am J Physiol."},{"key":"2020061806434086600_CIT0021","doi-asserted-by":"crossref","first-page":"G735","DOI":"10.1152\/ajpgi.90551.2008","article-title":"Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis","volume":"297","author":"Conlin","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"2020061806434086600_CIT0022","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/00004836-200003000-00009","article-title":"Secretion and tissue content of eosinophil cationic protein in Crohn\u2019s disease","volume":"30","author":"Winterkamp","year":"2000","journal-title":"J Clin Gastroenterol."},{"key":"2020061806434086600_CIT0023","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1136\/gut.2005.066423","article-title":"Eosinophil granulocytes are activated during the remission phase of ulcerative colitis","volume":"54","author":"Lampinen","year":"2005","journal-title":"Gut."},{"key":"2020061806434086600_CIT0024","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1136\/gut.2009.181701","article-title":"Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine","volume":"58","author":"Zheng","year":"2009","journal-title":"Gut."},{"key":"2020061806434086600_CIT0025","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1053\/j.gastro.2011.01.042","article-title":"Eosinophils express muscarinic receptors and corticotropin-releasing factor to disrupt the mucosal barrier in ulcerative colitis","volume":"140","author":"Wallon","year":"2011","journal-title":"Gastroenterology."},{"key":"2020061806434086600_CIT0026","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/s10620-007-9930-1","article-title":"A survey about irritable bowel syndrome in South Korea: prevalence and observable organic abnormalities in IBS patients","volume":"53","author":"Park","year":"2008","journal-title":"Dig Dis Sci."},{"key":"2020061806434086600_CIT0027","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3109\/00365521.2012.666672","article-title":"Subclinical mucosal inflammation in diarrhea-predominant irritable bowel syndrome (IBS) in a tropical setting","volume":"47","author":"De Silva","year":"2012","journal-title":"Scand J Gastroenterol."},{"key":"2020061806434086600_CIT0028","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.1365-2982.2000.00221.x","article-title":"Increased mast cells in the irritable bowel syndrome","volume":"12","author":"O\u2019Sullivan","year":"2000","journal-title":"Neurogastroenterol Motil."},{"key":"2020061806434086600_CIT0029","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology."},{"key":"2020061806434086600_CIT0030","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/labinvest.3700397","article-title":"Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum","volume":"86","author":"Keita","year":"2006","journal-title":"Lab Invest."},{"key":"2020061806434086600_CIT0031","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJM198712243172603","article-title":"Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study","volume":"317","author":"Schroeder","year":"1987","journal-title":"N Engl J Med."},{"key":"2020061806434086600_CIT0032","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1046\/j.1365-2036.1997.142318000.x","article-title":"The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress","volume":"11","author":"Francis","year":"1997","journal-title":"Aliment Pharmacol Ther."},{"key":"2020061806434086600_CIT0033","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3109\/00365521.2014.898084","article-title":"Prevalence of irritable bowel syndrome-like symptoms in ulcerative colitis patients with clinical and endoscopic evidence of remission: prospective multicenter study","volume":"49","author":"Fukuba","year":"2014","journal-title":"Scand J Gastroenterol."},{"key":"2020061806434086600_CIT0034","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1440-1827.2002.01354.x","article-title":"Differentiation between ulcerative colitis and Crohn\u2019s disease by a quantitative immunohistochemical evaluation of T lymphocytes, neutrophils, histiocytes and mast cells","volume":"52","author":"Sasaki","year":"2002","journal-title":"Pathol Int."},{"key":"2020061806434086600_CIT0035","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1136\/gut.16.11.861","article-title":"Mast cells and immunoglobulin E in inflammatory bowel disease","volume":"16","author":"Lloyd","year":"1975","journal-title":"Gut."},{"key":"2020061806434086600_CIT0036","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0046-8177(80)80072-4","article-title":"Crohn\u2019s disease: transmission electron microscopic studies. II. Immunologic inflammatory response. Alterations of mast cells, basophils, eosinophils, and the microvasculature","volume":"11","author":"Dvorak","year":"1980","journal-title":"Hum Pathol."},{"key":"2020061806434086600_CIT0037","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000236338","article-title":"Ultrastructural evidence for piecemeal and anaphylactic degranulation of human gut mucosal mast cells in vivo","volume":"99","author":"Dvorak","year":"1992","journal-title":"Int Arch Allergy Immunol."},{"key":"2020061806434086600_CIT0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2559.1996.262309.x","article-title":"Quantitative assessment of intestinal eosinophils and mast cells in inflammatory bowel disease","volume":"28","author":"Bischoff","year":"1996","journal-title":"Histopathology."},{"key":"2020061806434086600_CIT0039","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1465-9921-12-10","article-title":"Analysing the eosinophil cationic protein\u2013a clue to the function of the eosinophil granulocyte","volume":"12","author":"Bystrom","year":"2011","journal-title":"Respir Res."},{"key":"2020061806434086600_CIT0040","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/ibd\/izz024","article-title":"Eosinophils in inflammatory bowel disease","volume":"25","author":"Filippone","year":"2019","journal-title":"Inflamm Bowel Dis."},{"key":"2020061806434086600_CIT0041","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1111\/j.1572-0241.1999.01372.x","article-title":"Characterization of cytokine expression in the rectal mucosa of ulcerative colitis: correlation with disease activity","volume":"94","author":"Inoue","year":"1999","journal-title":"Am J Gastroenterol."},{"key":"2020061806434086600_CIT0042","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1111\/j.1572-0241.2002.05687.x","article-title":"Elevated serum eotaxin levels in patients with inflammatory bowel disease","volume":"97","author":"Mir","year":"2002","journal-title":"Am J Gastroenterol."},{"key":"2020061806434086600_CIT0043","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1189\/jlb.1212640","article-title":"CD14+CD33+ myeloid cell-CCL11-eosinophil signature in ulcerative colitis","volume":"94","author":"Lampinen","year":"2013","journal-title":"J Leukoc Biol."},{"key":"2020061806434086600_CIT0044","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1111\/j.1572-0241.1999.01223.x","article-title":"Increased intraluminal release of eosinophil granule proteins EPO, ECP, EPX, and cytokines in ulcerative colitis and proctitis in segmental perfusion","volume":"94","author":"Carlson","year":"1999","journal-title":"Am J Gastroenterol."},{"key":"2020061806434086600_CIT0045","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/JLB.3MA0517-175R","article-title":"Downregulated eosinophil activity in ulcerative colitis with concomitant primary sclerosing cholangitis","volume":"104","author":"Lampinen","year":"2018","journal-title":"J Leukoc Biol."},{"key":"2020061806434086600_CIT0046","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/ajg.2013.92","article-title":"Mast cell tryptase reduces junctional adhesion molecule-A (JAM-A) expression in intestinal epithelial cells: implications for the mechanisms of barrier dysfunction in irritable bowel syndrome","volume":"108","author":"Wilcz-Villega","year":"2013","journal-title":"Am J Gastroenterol."},{"key":"2020061806434086600_CIT0047","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.clim.2007.08.017","article-title":"Interferon-gamma and tumor necrosis factor-alpha disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction","volume":"126","author":"Li","year":"2008","journal-title":"Clin Immunol."},{"key":"2020061806434086600_CIT0048","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/01.mcg.0000190776.65526.da","article-title":"Bleeding colonic ulcer and eosinophilic colitis: a rare complication of nonsteroidal anti-inflammatory drugs","volume":"40","author":"Jim\u00e9nez-S\u00e1enz","year":"2006","journal-title":"J Clin Gastroenterol."},{"key":"2020061806434086600_CIT0049","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00004836-199901000-00021","article-title":"Strongyloidiasis colitis: a case report and review of the literature","volume":"28","author":"Al Samman","year":"1999","journal-title":"J Clin Gastroenterol."},{"key":"2020061806434086600_CIT0050","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/1756283X10392443","article-title":"Eosinophilic colitis: epidemiology, clinical features, and current management","volume":"4","author":"Alfadda","year":"2011","journal-title":"Therap Adv Gastroenterol."},{"key":"2020061806434086600_CIT0051","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1586\/17474124.2014.909727","article-title":"Cellular and molecular immunological mechanisms in eosinophilic esophagitis: an updated overview of their clinical implications","volume":"8","author":"Lucendo","year":"2014","journal-title":"Expert Rev Gastroenterol Hepatol."},{"key":"2020061806434086600_CIT0052","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2036.2009.04041.x","article-title":"Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof-of-concept study","volume":"30","author":"Corinaldesi","year":"2009","journal-title":"Aliment Pharmacol Ther."},{"key":"2020061806434086600_CIT0053","doi-asserted-by":"crossref","first-page":"e9688","DOI":"10.1097\/MD.0000000000009688","article-title":"Drug-induced eosinophilic pneumonia: a review of 196 case reports","volume":"97","author":"Bartal","year":"2018","journal-title":"Medicine (Baltimore)."},{"key":"2020061806434086600_CIT0054","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fmed.2017.00103","article-title":"Bidirectional mast cell-eosinophil interactions in inflammatory disorders and cancer","volume":"4","author":"Galdiero","year":"2017","journal-title":"Front Med (Lausanne)."},{"key":"2020061806434086600_CIT0055","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/ajg.2011.423","article-title":"Serum and colonic mucosal immune markers in irritable bowel syndrome","volume":"107","author":"Chang","year":"2012","journal-title":"Am J Gastroenterol."}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ibdjournal\/article-pdf\/26\/7\/974\/33402633\/izz328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ibdjournal\/article-pdf\/26\/7\/974\/33402633\/izz328.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T10:54:37Z","timestamp":1592477677000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/26\/7\/974\/5707481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,16]]},"references-count":55,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,1,16]]},"published-print":{"date-parts":[[2020,6,18]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izz328","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7]]},"published":{"date-parts":[[2020,1,16]]}}}