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This process is thought to occur irrespective of tooth wear or breakage. In this study, we aimed to determine if damage to teeth and premature tooth extraction affects tooth replacement timing long-term in juvenile green iguanas (Iguana iguana). First, we examined normal tooth development histologically using a BrdU pulse-chase analysis to detect label-retaining cells in replacement teeth and dental tissues. Next, we performed tooth extraction experiments for characterization of dental tissues after functional tooth (FT) extraction, including proliferation and \u03b2-Catenin expression, for up to 12\u2009weeks. We then compared these results to a newly analyzed historical dataset of X-rays collected up to 7\u2009months after FT damage and extraction in the green iguana. Results show that proliferation in the dental and successional lamina (SL) does not change after extraction of the FT, and proliferation occurs in the SL only when a tooth differentiates. Damage to an FT crown does not affect the timing of the tooth replacement cycle, however, complete extraction shifts the replacement cycle ahead by 4\u2009weeks by removing the need for resorption of the FT. These results suggest that traumatic FT loss affects the timing of the replacement cycle at that one position, which may have implications for tooth replacement patterning around the entire mouth.<\/jats:p>","DOI":"10.1093\/icb\/icaa099","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T11:23:22Z","timestamp":1593516202000},"page":"581-593","source":"Crossref","is-referenced-by-count":13,"title":["The Effects of Premature Tooth Extraction and Damage on Replacement Timing in the Green Iguana"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6630-1525","authenticated-orcid":false,"given":"Kirstin S","family":"Brink","sequence":"first","affiliation":[{"name":"Department of Oral Health Sciences, University of British Columbia, Vancouver, BC V6T 1Z4,\u00a0Canada"},{"name":"Department of Geological Sciences, University of Manitoba, 125 Dysart Road, Winnipeg, MB R3T 2N2, 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