{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T06:46:06Z","timestamp":1775976366024,"version":"3.50.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000183","name":"Army Research Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000183","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["W911NF-14-1-0376"],"award-info":[{"award-number":["W911NF-14-1-0376"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,22]]},"abstract":"<jats:title>Synopsis<\/jats:title>\n               <jats:p>In general, males should be particularly attentive to cues of sexual availability and females should advertize accordingly. Vaginal patency (i.e., the openness of the vagina) is a reliable indicator of sexual maturity; if the vagina is closed, the female is unable to copulate. The southern giant pouched rat (Cricetomys ansorgei) is unusual because females can have fully fused vaginal openings (i.e., vaginal nonpatency) despite being considered \u201cadults\u201d by other metrics. Moreover, some females reversibly close their vaginal openings. Thus, vaginal patency in the pouched rat is a \u201cflexible\u201d reproductive state. We subcutaneously implanted a long-acting GnRH agonist (deslorelin), which over time inhibits sex steroid secretion, to better understand the endocrinology and social behavior relating to vaginal patency in this species. We hypothesized that altering GnRH would impact both patency and behavior through its effects on circulating levels of estradiol. Six months of deslorelin treatment did not alter vaginal patency. Behaviorally, deslorelin-treated females spent less time interacting with, and were more aggressive towards males (compared to controls). Notably, deslorelin did not alter female scent marking. We conclude that behavioral receptivity, but not vaginal patency, is impacted by GnRH hormonal cascades in the pouched rat.<\/jats:p>","DOI":"10.1093\/icb\/icac037","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T16:01:04Z","timestamp":1652976064000},"page":"613-624","source":"Crossref","is-referenced-by-count":5,"title":["Effects of a Gonadotropin-Releasing Hormone Agonist on Sex Behavior in Females of the Southern Giant Pouched Rat"],"prefix":"10.1093","volume":"62","author":[{"given":"Beverly","family":"Lo","sequence":"first","affiliation":[{"name":"Department of Psychology, Cornell University , 211 Uris Hall, Ithaca, NY 14853, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5103-5674","authenticated-orcid":false,"given":"Angela R","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Psychology, Cornell University , 211 Uris Hall, Ithaca, NY 14853, 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