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However, establishing causal links among specific microbiome members remains difficult in corals because these communities are diverse and difficult to manipulate experimentally. We used Aiptasia, an emerging coral model system, to test how algal symbiont identity influences the structure and dynamics of the prokaryotic microbiome during heat stress. We generated clonal Aiptasia lines hosting two well-defined strains of photosynthetic algae in the family Symbiodiniaceae. We exposed these animals to an acute thermal stress assay while tracking prokaryotic dynamics with 16S sequencing. Among heat-stressed animals, algal strain was the strongest driver of prokaryotic community composition. We also identified line-associated indicator taxa that may be linked to differences in bleaching resistance. Finally, the more thermally sensitive host-algal association showed greater intersample dissimilarity in prokaryotic community structure under heat stress, suggesting that sustained microbiome variability may characterize more stress-sensitive cnidarian holobionts. These results suggest algal symbionts may shape bleaching responses not only through effects on host physiology, but also through their influence on prokaryotic microbiome dynamics.<\/jats:p>","DOI":"10.1093\/icb\/icag086","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:19:22Z","timestamp":1782487162000},"source":"Crossref","is-referenced-by-count":0,"title":["Symbiont Identity Impacts Prokaryotic Microbiome Dynamics During Heat Stress in a Model System for Corals"],"prefix":"10.1093","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2402-5002","authenticated-orcid":false,"given":"Victoria M","family":"Glynn","sequence":"first","affiliation":[{"name":"McGill University Department of Biology and Redpath Museum, , Montr\u00e9al, Qu\u00e9bec H3A 1B1 ,","place":["Canada"]},{"name":"Naos Marine Laboratories, Smithsonian Tropical Research Institute (STRI) , Anc\u00f3n, Panam\u00e1 ,","place":["Republic of Panama"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan C","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Carnegie Institution for Science Department of Embryology, , Baltimore,MD 21218 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip A","family":"Cleves","sequence":"additional","affiliation":[{"name":"Carnegie Institution for Science Department of Embryology, , Baltimore,MD 21218 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3044-2531","authenticated-orcid":false,"given":"Rowan D H","family":"Barrett","sequence":"additional","affiliation":[{"name":"McGill University Department of Biology and Redpath Museum, , Montr\u00e9al, Qu\u00e9bec H3A 1B1 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