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We describe 3 children (age 2\u20136\u2009years, weight 13\u201317\u2009kg) with congenital heart disease who developed intracardiac thrombosis, and in whom typical treatments had failed (in 1) or were considered impractical (in 2). All were treated with apixaban 2.5\u2009mg orally twice daily with complete (in 2) or partial (in 1) thrombus resolution and no clinical bleeding events.<\/jats:p>","DOI":"10.1093\/icvts\/ivaa041","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T20:10:01Z","timestamp":1581365401000},"page":"950-951","source":"Crossref","is-referenced-by-count":11,"title":["Apixaban for treatment of intracardiac thrombosis in children with congenital heart disease"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-6660","authenticated-orcid":false,"given":"Jesse J","family":"Esch","sequence":"first","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8354-6265","authenticated-orcid":false,"given":"Amy","family":"Hellinger","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G","family":"Friedman","sequence":"first","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina J","family":"VanderPluym","sequence":"first","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,28]]},"reference":[{"key":"2020052604000602600_ivaa041-B1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCULATIONAHA.114.014807","article-title":"Apixaban in comparison with warfarin in patients with atrial fibrillation and valvular heart disease: findings from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial","volume":"132","author":"Avezum","year":"2015","journal-title":"Circulation"},{"key":"2020052604000602600_ivaa041-B2","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1055\/s-0039-1679938","article-title":"PREVAPIX-ALL: apixaban compared to standard of care for prevention of venous thrombosis in paediatric acute lymphoblastic leukaemia (ALL)\u2014rationale and design","volume":"119","author":"O\u2019Brien","year":"2019","journal-title":"Thromb Haemost"},{"key":"2020052604000602600_ivaa041-B3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ahj.2019.08.002","article-title":"A multi-national trial of a direct oral anticoagulant in children with cardiac disease: design and rationale of the Safety of ApiXaban On Pediatric Heart disease On the preventioN of Embolism (SAXOPHONE) study","volume":"217","author":"Payne","year":"2019","journal-title":"Am Heart J"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/30\/6\/950\/33290791\/ivaa041.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/30\/6\/950\/33290791\/ivaa041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T08:00:34Z","timestamp":1590480034000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/30\/6\/950\/5813300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,28]]},"references-count":3,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,3,28]]},"published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivaa041","relation":{},"ISSN":["1569-9293","1569-9285"],"issn-type":[{"value":"1569-9293","type":"print"},{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,6]]},"published":{"date-parts":[[2020,3,28]]}}}