{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:36:34Z","timestamp":1771468594893,"version":"3.50.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Foundation for Cardiac Surgery Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The long-term outcome of tetralogy of Fallot (TOF) is determined by progressive right ventricular (RV) dysfunction through pulmonary regurgitation (PR) and the risk of malignant arrhythmia. Although mechano-electrical coupling in TOF is well-known, its time effect on the inducibility of arrhythmia remains ill-defined. The goal of this study was to investigate the mechano-electrical properties at different times in animals with chronic PR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>PR was induced by a transannular patch with limited RV scarring in infant pigs. Haemodynamic assessment included biventricular pressure\u2013volume loops after 3 (n\u2009=\u20098) and 6\u2009months (n\u2009=\u20097) compared to controls (n\u2009=\u20095). The electrophysiological study included endocardial monophasic action potential registration, intraventricular conduction velocity and induction of ventricular arrhythmia by burst pacing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Progressive RV dilation was achieved at 6\u2009months (RV end-diastolic volume 143\u2009\u00b1\u200913 ml\/m2\u2014RV end-systolic volume 96\u2009\u00b1\u20097 ml\/m2; P\u2009&amp;lt;\u20090.001), in association with depressed RV contractility (preload recruitable stroke work-slope: 19\u2009\u00b1\u20091 and 11\u2009\u00b1\u20093 Mw.ml\u22121.s\u22121 for control and 6\u2009m; P\u2009&amp;lt;\u20090.001) and left ventricular contractility (preload recruitable stroke work-slope: 60\u2009\u00b1\u200913 and 40\u2009\u00b1\u200911 Mw.ml\u22121.s\u22121 for control and 6\u2009m; P\u2009=\u20090.005). Concomitant to QRS prolongation, monophasic action potential90-duration and dispersion at the RV and left ventricle were increased at 6\u2009months. Intraventricular conduction was delayed only in the RV at 6\u2009months (1.8\u2009\u00b1\u20090.2 and 2.4\u2009\u00b1\u20090.6 m\/s for group 6M and the control group; P\u2009=\u20090.035). Sustained ventricular arrhythmias were not inducible.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In animals yielding the sequelae of a contemporary operation for TOF, mechano-electrical alterations are progressive and affect predominantly the RV after midterm exposure of PR. Because ventricular arrhythmias were not inducible despite significant RV dilation, the data suggest that the haemodynamic RV deterioration effectively precedes the risk of inducing sustained arrhythmia after TOF repair and opens a window for renewed stratification of contemporary risk factors of ventricular arrhythmias in patients operated on with currently used pulmonary valve- and RV-related techniques.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivaa047","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T12:14:18Z","timestamp":1582028058000},"page":"129-137","source":"Crossref","is-referenced-by-count":8,"title":["Study of the time-relationship of the mechano-electrical interaction in an animal model of tetralogy of Fallot: implications for the risk assessment of ventricular arrhythmias"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3786-0699","authenticated-orcid":false,"given":"Thierry","family":"Bove","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Gent, Gent, Belgium"},{"name":"Laboratory of Experimental Cardiac Surgery - Cardio-Circulatory Physiology, Faculty of Medical Sciences, University Gent, Gent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahi","family":"Alipour Symakani","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Cardiac Surgery - Cardio-Circulatory Physiology, Faculty of Medical Sciences, University Gent, Gent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Verbeke","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Cardiac Surgery - Cardio-Circulatory Physiology, Faculty of Medical Sciences, University Gent, Gent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Vral","sequence":"first","affiliation":[{"name":"Radiobiology Research Unit, Faculty of Biomedical Science, University Gent, Gent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milad","family":"El Haddad","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology and Electrophysiology, University Hospital Gent, Gent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-6889","authenticated-orcid":false,"given":"Hans","family":"De Wilde","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology and Electrophysiology, University Hospital Gent, Gent, Belgium"},{"name":"Department of Pediatric Cardiology, University Hospital Gent, Gent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Stroobandt","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology and Electrophysiology, University Hospital Gent, Gent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"De Pooter","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology and Electrophysiology, University Hospital Gent, Gent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,3]]},"reference":[{"key":"2020070114041265300_ivaa047-B1","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/S0735-1097(97)00318-5","article-title":"Long-term survival in patients with repair of tetralogy of Fallot: 36-year follow-up of 490 survivors of the first year after surgical repair","volume":"30","author":"Nollert","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"2020070114041265300_ivaa047-B2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0140-6736(00)02714-8","article-title":"Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: a multicentre study","volume":"356","author":"Gatzoulis","year":"2000","journal-title":"Lancet"},{"key":"2020070114041265300_ivaa047-B3","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1161\/01.CIR.0000126495.11040.BD","article-title":"Value of programmed ventricular stimulation after tetralogy of Fallot repair: a multicenter study","volume":"109","author":"Khairy","year":"2004","journal-title":"Circulation"},{"key":"2020070114041265300_ivaa047-B4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1161\/01.CIR.92.2.231","article-title":"Mechanoelectrical interaction in tetralogy of Fallot. 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