{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T14:53:38Z","timestamp":1742396018309,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Swiss Heart Foundation national","award":["FF17007"],"award-info":[{"award-number":["FF17007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Transcatheter aortic root repair is still not available because of the technical challenge of coronary perfusion. The use of chimney grafts for coronary ostia can be an option and we tested the flow-through coronary chimney grafts deployed in a 3-dimensional-printed root model as part of a transcatheter aortic root repair system.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A 3-dimensional-printed root was used to test the coronary flow after the deployment of 1 root endograft (28\u2009mm diameter) and two 6-mm diameter 10-cm long coronary chimney grafts. Continuous coronary flows were measured in a bench test at different pressure levels (60, 80 and 100\u2009mmHg) and compared to target coronary flows (250\u2009ml\/min at rest for the left and 150\u2009ml\/min at rest for the right coronary artery).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The computed tomography scan-based root was modified with two 5-mm diameter coronary conduits to overcome the limits of the original 3-dimensional-printed coronary ostia. The root was placed in the hydrodynamic system: adjusted coronary free flow at 60, 80 and 100\u2009mmHg of pressure was 1913, 2200 and 2480\u2009ml\/min for left coronary and 1633, 2026 and 2366\u2009ml\/min for right coronary, respectively. After endografts deployment, mean chimney graft flow at 60, 80 and 100\u2009mmHg of pressure was 1053\u2009ml\/min (\u221245%), 1306\u2009ml\/min (\u221241%) and 1502\u2009ml\/min (\u221240%) for the left coronary and 1100\u2009ml\/min (\u221233%), 1460\u2009ml\/min (\u221228%) and 1626\u2009ml\/min (\u221231%) for the right coronary, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In this preliminary study, chimney grafts for transcatheter aortic root repair provided 830% of target flow in the right coronary (\u221231% of free flow) and 414% of target flow in the left coronary (\u221242% of free flow) which is more than sufficient for both coronaries in real-life conditions. The potential of this approach should be further explored with specifically designed endografts.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivaa056","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T12:24:14Z","timestamp":1583151854000},"page":"121-128","source":"Crossref","is-referenced-by-count":3,"title":["Transcatheter aortic root replacement with chimney grafts for coronary perfusion: a preliminary test in a three-dimensional-printed root model"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2837-3242","authenticated-orcid":false,"given":"Enrico","family":"Ferrari","sequence":"first","affiliation":[{"name":"Cardiovascular Surgery Unit, Cardiocentro Ticino, Lugano, Switzerland"},{"name":"Cardiovascular Surgery Unit, University Hospital of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2566-3524","authenticated-orcid":false,"given":"Martin","family":"Scoglio","sequence":"first","affiliation":[{"name":"Cardiovascular Research Unit, University Hospital of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Piazza","sequence":"first","affiliation":[{"name":"Cardiovascular Research Unit, University Hospital of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3691-1709","authenticated-orcid":false,"given":"Francesco","family":"Maisano","sequence":"first","affiliation":[{"name":"Cardiovascular Surgery Unit, University Hospital of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-9340","authenticated-orcid":false,"given":"Ludwig Karl","family":"von Segesser","sequence":"first","affiliation":[{"name":"Cardiovascular Research Unit, University Hospital of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Berdajs","sequence":"first","affiliation":[{"name":"Cardiovascular Surgery Unit, University Hospital of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,17]]},"reference":[{"key":"2020070114044029100_ivaa056-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejcts.2008.04.039","article-title":"Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions (EAPCI)","volume":"34","author":"Vahanian","year":"2008","journal-title":"Eur J 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