{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:33:56Z","timestamp":1789259636779,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Implantation of a personalized external aortic root support (PEARS) can prevent dilatation of the aortic root and ascending aorta in patients with aortopathy of various aetiologies. Because PEARS is an emerging technology, all aspects concerning indications, surgical technique and safety should be elucidated. Our goal was to summarize all of these aspects so that physicians and patients would have sufficient information to evaluate this alternative approach.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Between April 2004 and March 2020, 317 patients underwent PEARS operations at 25 surgical centres in 9 countries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The most common indication was Marfan syndrome (57%). The single perioperative death represented a mortality of 0.3%. The long-term experience comprises 871 patient\/years with 1 patient living for 15\u2009years and 19 patients living for more than 10\u2009years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>PEARS seems to be a promising method of treatment of dilatation of the aortic root and\/or ascending aorta. Multicentre observational studies are needed to gain more experience because this operation is still uncommon and the number of operations per surgeon\/centre is low.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivaa111","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T19:13:03Z","timestamp":1591125183000},"page":"342-345","source":"Crossref","is-referenced-by-count":17,"title":["Personalized external aortic root support"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-5942","authenticated-orcid":false,"given":"Petr","family":"Nemec","sequence":"first","affiliation":[{"name":"Centre of Cardiovascular Surgery and Transplantations, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Pepper","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1519-2469","authenticated-orcid":false,"given":"Petr","family":"Fila","sequence":"additional","affiliation":[{"name":"Centre of Cardiovascular Surgery and Transplantations, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"2020082820123300100_ivaa111-B1","article-title":"2017 ESC\/EACTS Guidelines for the management of valvular heart disease","author":"Falk","journal-title":"Eur J Cardiothorac Surg 2017;52:616\u201364"},{"key":"2020082820123300100_ivaa111-B2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/ejcts\/ezy300","article-title":"Valve-sparing aortic root replacement (David I procedure) in Marfan disease: single-centre 20-year experience in more than 100 patients","volume":"55","author":"Martens","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020082820123300100_ivaa111-B3","author":"Golesworthy"},{"key":"2020082820123300100_ivaa111-B4","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(04)17308-X","article-title":"The Tailor of Gloucester: a jacket for the Marfan\u2019s aorta","volume":"364","author":"Golesworthy","year":"2004","journal-title":"Lancet"},{"key":"2020082820123300100_ivaa111-B5","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.jacc.2018.06.053","article-title":"External aortic root support to prevent aortic dilatation in patients with Marfan syndrome","volume":"72","author":"Izgi","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2020082820123300100_ivaa111-B6","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/0003-4975(94)90160-0","article-title":"Conservative operation in the management of annular dilatation and ascending aortic aneurysm","volume":"57","author":"Robicsek","year":"1994","journal-title":"Ann Thorac Surg"},{"key":"2020082820123300100_ivaa111-B7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13019-016-0499-7","article-title":"A \u201ccompare and contrast\u201d exercise: wrapping versus personalised external aortic root support (PEARS)","volume":"11","author":"Treasure","year":"2016","journal-title":"J Cardiothorac Surg"},{"key":"2020082820123300100_ivaa111-B8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13019-016-0487-y","article-title":"Computed tomography angiography of aorta subjected to external wrapping","volume":"11","author":"P\u0142onek","year":"2016","journal-title":"J Cardiothorac Surg"},{"key":"2020082820123300100_ivaa111-B9","doi-asserted-by":"crossref","first-page":"S488","DOI":"10.21037\/jtd.2017.04.57","article-title":"Wrapping of the ascending aorta revisited-is there any role left for conservative treatment of ascending aortic aneurysm?","volume":"9","author":"Gonz\u00e1lez-Santos","year":"2017","journal-title":"J Thorac Dis"},{"key":"2020082820123300100_ivaa111-B10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/icvts\/ivx009","article-title":"Support of the aortic wall: a histological study in sheep comparing a macroporous mesh with low-porosity vascular graft of the same polyethylene terephthalate material","volume":"25","author":"Van Hoof","year":"2017","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2020082820123300100_ivaa111-B11","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.ijcard.2016.06.248","article-title":"Personalised external aortic root support (PEARS): utilisation in dilatational aortopathies after the arterial switch operation V4","volume":"220","author":"Austin","year":"2016","journal-title":"Int J Cardiol"},{"key":"2020082820123300100_ivaa111-B12","doi-asserted-by":"crossref","first-page":"e499","DOI":"10.1016\/j.athoracsur.2016.05.031","article-title":"An option for concomitant management of moderate Marfan root aneurysm at the time of mitral valve repair: a role for personalized external aortic root support","volume":"102","author":"Benedetto","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"2020082820123300100_ivaa111-B13","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1038\/s41598-020-59554-7","article-title":"Mechano-biological adaptation of the pulmonary artery exposed to systemic conditions","volume":"10","author":"Vanderveken","year":"2020","journal-title":"Sci Rep"},{"key":"2020082820123300100_ivaa111-B14","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/icvts\/ivy134","article-title":"Reinforcing the pulmonary artery autograft in the aortic position with a textile mesh: a histological evaluation","volume":"27","author":"Vanderveken","year":"2018","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2020082820123300100_ivaa111-B15","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1080\/17434440.2019.1685380","article-title":"A review of pulmonary autograft external support in the Ross procedure","volume":"16","author":"Chauvette","year":"2019","journal-title":"Expert Rev Med Devices"},{"key":"2020082820123300100_ivaa111-B16","first-page":"mmt004","article-title":"Implantation of an individually computer-designed and manufactured external support for the Marfan aortic root","volume":"2013","author":"Pepper","year":"2013","journal-title":"Multimed Man Cardiothorac Surg"},{"key":"2020082820123300100_ivaa111-B17","doi-asserted-by":"crossref","first-page":"e000725","DOI":"10.1136\/bmjopen-2011-000725","article-title":"A method for early evaluation of a recently introduced technology by deriving a comparative group from existing clinical data: a case study in external support of the Marfan aortic root","volume":"2","author":"Treasure","year":"2012","journal-title":"BMJ Open"},{"key":"2020082820123300100_ivaa111-B18","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/ejcts\/ezu415","article-title":"Histology of a Marfan aorta 4.5 years after personalized external aortic root support","volume":"48","author":"Pepper","year":"2015","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020082820123300100_ivaa111-B19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/diseases3010002","article-title":"Personalised external aortic root support (PEARS) compared with alternatives for people with life-threatening genetically determined aneurysms of the aortic root","volume":"3","author":"Treasure","year":"2015","journal-title":"Diseases"},{"key":"2020082820123300100_ivaa111-B20","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1136\/heartjnl-2013-304913","article-title":"Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1-9 year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the published results of aortic root replacement","volume":"100","author":"Treasure","year":"2014","journal-title":"Heart"},{"key":"2020082820123300100_ivaa111-B21","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/ejcts\/ezw078","article-title":"Personalized external aortic root support: a review of the current status","volume":"50","author":"Treasure","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020082820123300100_ivaa111-B22","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jacc.2018.05.073","article-title":"Aortic root support in Marfan patients: time for a closer look?","volume":"72","author":"Borger","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2020082820123300100_ivaa111-B23","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1093\/ejcts\/ezw440","article-title":"External aortic root support: a viable alternative treatment option? Consent and duty of candour","volume":"51","author":"Jahangiri","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020082820123300100_ivaa111-B24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/ejcts\/ezw117","article-title":"When does an \u201cemerging technology\u201d emerge into the therapeutic arena? Should we be offering personalized external aortic root support?","volume":"50","author":"Hamilton","year":"2016","journal-title":"Eur J Cardiothorac Surg"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/31\/3\/342\/33694412\/ivaa111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/31\/3\/342\/33694412\/ivaa111.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T17:04:59Z","timestamp":1598893499000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/31\/3\/342\/5881571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,8,6]]},"published-print":{"date-parts":[[2020,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivaa111","relation":{},"ISSN":["1569-9285"],"issn-type":[{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,9]]},"published":{"date-parts":[[2020,8,6]]}}}