{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T08:46:26Z","timestamp":1771058786262,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T00:00:00Z","timestamp":1605916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>There is growing interest in the aortic valve (AV) neocuspidalization technique for the treatment of aortic valve disease (AVD). We report our medium-term results with this procedure performed in a paediatric patient population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Between July 2016 and May 2020, 22 patients with both congenital and acquired isolated AVD were treated with neocuspidalization. The primary outcome was progression of the preoperatively assessed AVD in the immediate postoperative course and at follow-up. Secondary outcome was freedom from reintervention by material used. Potential predictors of failure were analysed in relation to the primary outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The median age at operation was 13.9 (interquartile range, 9.8\u201316.2) years, and the prevailing AV defect was stenosis in 10 cases (45%) and incompetence in 12 (55%). Pre-treated autologous pericardium was used in 13 patients whereas bovine pericardium in 9. Effective treatment of AV stenosis or regurgitation was achieved and remained stable over a median follow-up of 11.3 (4.7\u201321) months. Three patients required AV replacement at 4.9, 3.5 and 33\u2009months. At follow-up, an upward trend of both median indexed vena contracta jet widths and aortic peak and mean gradients were recorded, the latter associated with a failure to grow the aortic annulus. Predictor of such outcome turned out to be the use of bovine pericardium. A significant inverse linear correlation between AV peak gradient at follow-up and preoperative aortic annular size (P\u2009=\u20090.008) was also demonstrated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The Ozaki procedure is safe and effective in paediatric patients with AV disease. The use of heterologous pericardium should probably be minimized. Moreover, preoperative small aortic annuli should probably be promptly treated by means of an associated ring enlargement procedure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivaa237","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T19:21:43Z","timestamp":1600716103000},"page":"111-117","source":"Crossref","is-referenced-by-count":17,"title":["Aortic valve neocuspidalization in paediatric patients with isolated aortic valve disease: early experience"],"prefix":"10.1093","volume":"32","author":[{"given":"Angelo","family":"Polito","sequence":"first","affiliation":[{"name":"Pediatric and Neonatal Intensive Care Unit, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-6651","authenticated-orcid":false,"given":"Sonia B","family":"Albanese","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Bambino Ges\u00f9 Children\u2019s Hospital and Research Institute, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7117-2219","authenticated-orcid":false,"given":"Enrico","family":"Cetrano","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Bambino Ges\u00f9 Children\u2019s Hospital and Research Institute, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-6848","authenticated-orcid":false,"given":"Marianna","family":"Cicenia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Bambino Ges\u00f9 Children\u2019s Hospital and Research Institute, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2991-4917","authenticated-orcid":false,"given":"Gabriele","family":"Rinelli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Bambino Ges\u00f9 Children\u2019s Hospital and Research Institute, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3908-5091","authenticated-orcid":false,"given":"Adriano","family":"Carotti","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Bambino Ges\u00f9 Children\u2019s Hospital and Research Institute, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,21]]},"reference":[{"key":"2022030919162635400_ivaa237-B1","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.athoracsur.2007.12.082","article-title":"Guidelines for reporting mortality and morbidity after cardiac valve interventions","volume":"85","author":"Akins","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"2022030919162635400_ivaa237-B2","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1016\/j.jacc.2016.04.021","article-title":"Aortic valve replacement and the Ross operation in children and young adults","volume":"67","author":"Sharabiani","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2022030919162635400_ivaa237-B3","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(67)90794-5","article-title":"Replacement of aortic and mitral valves with a pulmonary autograft","volume":"290","author":"Ross","year":"1967","journal-title":"Lancet"},{"key":"2022030919162635400_ivaa237-B4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jtcvs.2013.02.037","article-title":"The Ross procedure in patients aged less than 18 years: the midterm results","volume":"147","author":"Brancaccio","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022030919162635400_ivaa237-B5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jtcvs.2008.02.080","article-title":"Ross operation: 16-year experience","volume":"136","author":"Elkins","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022030919162635400_ivaa237-B6","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.athoracsur.2005.04.057","article-title":"Pediatric autograft aortic root replacement: a prospective follow-up study","volume":"80","author":"Takkenberg","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"2022030919162635400_ivaa237-B7","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1136\/heartjnl-2014-305873","article-title":"Two decades of experience with the Ross operation in neonates, infants and children from the Italian Paediatric Ross Registry","volume":"100","author":"Luciani","year":"2014","journal-title":"Heart"},{"key":"2022030919162635400_ivaa237-B8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jtcvs.2015.09.083","article-title":"Outcome after aortic valve replacement in children: a systematic review and meta-analysis","volume":"151","author":"Etnel","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022030919162635400_ivaa237-B9","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1510\/icvts.2010.253682","article-title":"Aortic valve reconstruction using self-developed aortic valve plasty system in aortic valve disease","volume":"12","author":"Ozaki","year":"2011","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2022030919162635400_ivaa237-B10","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/j.jtcvs.2018.01.087","article-title":"Midterm outcomes after aortic valve neocuspidization with glutaraldehyde-treated autologous pericardium","volume":"155","author":"Ozaki","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022030919162635400_ivaa237-B11","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1016\/j.jtcvs.2019.09.176","article-title":"The utility of aortic valve leaflet reconstruction techniques in children and young adults","volume":"159","author":"Wiggins","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022030919162635400_ivaa237-B12","article-title":"Congenital aortic and truncal valve reconstruction utilizing the Ozaki technique: short\u2013term clinical results","author":"Baird","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022030919162635400_ivaa237-B13","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.athoracsur.2013.11.086","article-title":"Techniques of autologous pericardial leaflet replacement for aortic valve reconstruction","volume":"98","author":"Rankin","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"2022030919162635400_ivaa237-B14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0022-5223(19)36552-3","article-title":"Bilateral enlargement of the aortic valve ring for valve replacement in children","volume":"102","author":"Yamaguchi","year":"1991","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022030919162635400_ivaa237-B15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01.hco.0000153951.31887.a6","article-title":"Functional classification of aortic root\/valve abnormalities and their correlation with etiologies and surgical procedures","volume":"20","author":"El Khoury","year":"2005","journal-title":"Curr Opin Cardiol"},{"key":"2022030919162635400_ivaa237-B16","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jtcvs.2007.09.057","article-title":"Surgical aortic valvuloplasty in children and adolescents with aortic regurgitation: acute and intermediate effects on aortic valve function and left ventricular dimensions","volume":"135","author":"Bacha","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022030919162635400_ivaa237-B17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1053\/j.pcsu.2012.01.004","article-title":"Aortic valve reconstruction in the young infants and children","volume":"15","author":"Baird","year":"2012","journal-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu"},{"key":"2022030919162635400_ivaa237-B18","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1136\/hrt.2009.190520","article-title":"Aortic valve surgery in children","volume":"97","author":"d\u2019Udekem","year":"2011","journal-title":"Heart"},{"key":"2022030919162635400_ivaa237-B19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jtcvs.2012.11.033","article-title":"Long-term results of a strategy of aortic valve repair in the pediatric population","volume":"145","author":"d'Udekem","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022030919162635400_ivaa237-B20","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jtcvs.2014.03.029","article-title":"Reply to the editor","volume":"148","author":"Brancaccio","year":"2014","journal-title":"J Thorac Cardiocavsc Surg"},{"key":"2022030919162635400_ivaa237-B21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/2150135113485763","article-title":"Patient age at the Ross operation in children influences aortic root dimensions and aortic regurgitation","volume":"4","author":"H\u00f6rer","year":"2013","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"2022030919162635400_ivaa237-B22","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1177\/2150135119878108","article-title":"The Ozaki procedure with CardioCel patch for children and young adults with aortic valve disease: preliminary experience\u2014a word of caution","volume":"10","author":"Chivers","year":"2019","journal-title":"World J Pediatr Congenit Heart Surg"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/32\/1\/111\/42780762\/ivaa237.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/32\/1\/111\/42780762\/ivaa237.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T19:17:36Z","timestamp":1646853456000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/32\/1\/111\/5998280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,21]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,11,21]]},"published-print":{"date-parts":[[2021,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivaa237","relation":{},"ISSN":["1569-9285"],"issn-type":[{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1]]},"published":{"date-parts":[[2020,11,21]]}}}