{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:33:39Z","timestamp":1780565619495,"version":"3.54.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Venoarterial extracorporeal life support (ECLS) has emerged as a potentially life-saving treatment option in therapy-refractory cardiocirculatory failure, but longer-term outcome is poorly defined. Here, we present a comprehensive follow-up analysis covering all major organ systems.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>From February 2012 to December 2016, 180 patients were treated with ECLS for therapy-refractory cardiogenic shock or cardiac arrest. The 30-day survival was 43.9%, and 30-day survivors (n\u2009=\u200979) underwent follow-up analysis with the assessment of medium-term survival, quality of life, neuropsychological, cardiopulmonary and end-organ status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>After a median of 1.9 (1.1\u20133.6) years (182.4 patient years), 45 of the 79 patients (57.0%) were alive, 35.4% had died and 7.6% were lost to follow-up. Follow-up survival estimates were 78.0% at 1, 61.2% at 3 and 55.1% at 5 years. NYHA class at follow-up was \u2264II for 83.3%. The median creatinine was 1.1 (1.0\u20131.4) mg\/dl, and the median bilirubin was 0.8 (0.5\u20131.0) mg\/dl. No patient required dialysis. Overall, 94.4% were free from moderate or severe disability, although 11.1% needed care. Full re-integration into social life was reported by 58.3%, and 39.4% were working. Quality of life was favourable for mental components, but a subset showed deficits in physical aspects. While age was the only peri-implantation parameter significantly predicting medium-term survival, adverse events and functional status at discharge or 30\u2009days were strong predictors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>This study demonstrates positive medium-term outcome with high rates of independence in daily life and self-care but a subset of 10\u201320% suffered from sustained impairments. Our results indicate that peri-implantation parameters lack predictive power but downstream morbidity and functional status at discharge or 30\u2009days can help identify patients at risk for poor recovery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivaa312","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T04:20:38Z","timestamp":1606882838000},"page":"607-615","source":"Crossref","is-referenced-by-count":9,"title":["Extracorporeal life support in therapy-refractory cardiocirculatory failure: looking beyond 30 days"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-9165","authenticated-orcid":false,"given":"Sabina P W","family":"Guenther","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Munich, Ludwig-Maximilian-University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Hornung","sequence":"additional","affiliation":[{"name":"Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilian-University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Joskowiak","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Munich, Ludwig-Maximilian-University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polyxeni","family":"Vlachea","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Munich, Ludwig-Maximilian-University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Feil","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Munich, Ludwig-Maximilian-University, Munich, 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