{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:14:25Z","timestamp":1740136465009,"version":"3.37.3"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Chronic kidney disease (CKD) is prevalent in patients undergoing cardiovascular surgery, and it negatively impacts procedural outcomes; however, its influence on the outcomes of aortic surgery has not been well studied. This study aims to elucidate the importance of CKD on the outcomes of aortic root replacement (ARR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Patients who underwent ARR between 2005 and 2019 were retrospectively reviewed (n\u2009=\u2009882). Patients were divided into 3 groups based on the Kidney Disease: Improving Global Outcomes criteria: Group 1 [estimated glomerular filtration rate (eGFR)\u2009\u2265\u200960 ml\/min\/1.73 m2, n\u2009=\u2009421); Group 2 (eGFR\u2009=\u200930\u201359 ml\/min\/1.73 m2, n\u2009=\u2009424); and Group 3 (eGFR\u2009&amp;lt;\u200930 ml\/min\/1.73 m2, n\u2009=\u200937). To reduce potential confounding, a propensity score matching was also performed between Group 1 and the combined group of Group 2 and Group 3. The primary end point was 10-year survival. Secondary end points were in-hospital mortality and perioperative morbidity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Severe CKD patients presented with more advanced overall chronic and acute illnesses. Kaplan\u2013Meier analysis showed a significant correlation between CKD stage and 10-year survival (log-rank P &amp;lt; 0.001). The number of events for Group 1 was 15, Group 2 was 49 and Group 3 was 11 in 10\u2009years. Group 3 had significantly higher in-hospital mortality (13.5% vs 3.5% in Group 2 vs 0.7% in Group 1, P &amp;lt; 0.001) and stroke (8.1% vs 7.1% vs 1.2%, P &amp;lt; 0.001) as well as introduction to new dialysis (27.0% vs 5.4% vs 1.7%, P &amp;lt; 0.001). eGFR was shown to be an independent predictor of mortality (hazard ratio, 0.98; 95% confidence interval, 0.96\u20130.99). Comparison between propensity matched groups showed similar postoperative outcomes, and eGFR was still identified as a predictor of mortality (hazard ratio, 0.97; 95% confidence interval, 0.95\u20130.99).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Higher stage in CKD negatively impacts the long-term survival in patients who are undergoing ARR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivaa320","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T20:22:54Z","timestamp":1606767774000},"page":"573-581","source":"Crossref","is-referenced-by-count":0,"title":["Chronic kidney disease stage stratifies short- and long-term outcomes after aortic root replacement"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3207-750X","authenticated-orcid":false,"given":"Tsuyoshi","family":"Yamabe","sequence":"first","affiliation":[{"name":"Division of Cardiothoracic and Vascular Surgery, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY, USA"},{"name":"Department of Cardiovascular Surgery, Shonan-Kamakura General Hospital, Kamakura, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic and Vascular Surgery, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A","family":"Kurlansky","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic and Vascular Surgery, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzuka","family":"Nitta","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic and Vascular Surgery, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saveliy","family":"Kelebeyev","sequence":"additional","affiliation":[{"name":"Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casidhe-Nicole R","family":"Bethancourt","sequence":"additional","affiliation":[{"name":"Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"George","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic and Vascular Surgery, New York Presbyterian Hospital, Columbia University Medical 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