{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T09:45:07Z","timestamp":1747647907631,"version":"3.37.3"},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A best evidence topic was written according to a structured protocol. The question addressed was: In patients with mesothelioma who develop a local recurrence after macroscopic complete resection (MCR) surgery, does performing a second radical surgery lead to improvement in survival? A total of 2076 papers were identified using the reported search, of which 3 represented the best evidence to answer the clinical question. The authors, date, journal, country, study type, population, outcomes and key results are tabulated. The 2 largest studies included 16 patients each who underwent a second surgery for radical resection of recurrence after MCR for mesothelioma. One study (with 16 chest wall resections) had no in-hospital mortality, whereas the other study showed 2\/16 (12.5%) patients dying in the hospital, both of whom had a contralateral pleurectomy. One study correlated the median survival after the second surgery with the time to recurrence and epithelioid pathology. The other study showed better post-recurrence survival after a second surgery, with patients having a significantly longer median post-recurrence survival (16\u2009months) compared with those who received other types of second-line therapy (9\u2009months) and those who received no therapy at all (2\u2009months) (P\u2009&amp;lt;\u20090.0005), although selection bias is a possibility. The last study included 8 patients who underwent a second surgery for radical intent after MCR for mesothelioma. The median time to recurrence was 29\u2009months and the survival after second surgery was 14.5\u2009months with no correlation to disease-free interval (expected due to the small number of patients). In patients presenting with recurrence of mesothelioma after an MCR procedure, radical surgery to resect the recurrent tumour could have a role in improvement of survival in selected patients. Positive prognostic factors include epithelioid pathology and a longer disease-free interval after the first procedure.<\/jats:p>","DOI":"10.1093\/icvts\/ivaa338","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T12:21:29Z","timestamp":1608380489000},"page":"761-763","source":"Crossref","is-referenced-by-count":3,"title":["Recurrence of mesothelioma after a macroscopic complete resection procedure: is a second radical surgery justified?"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7597-6070","authenticated-orcid":false,"given":"Hany Hasan","family":"Elsayed","sequence":"first","affiliation":[{"name":"Thoracic Surgery Department, Ain Shams University Hospital, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aly Sherif","family":"Hassaballa","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic Surgery Department, Ain Shams University Hospital, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taha Aly","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic Surgery Department, Ain Shams University Hospital, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem Youssef","family":"Sharkawy","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic Surgery Department, Ain Shams University Hospital, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"key":"2021051021291397500_ivaa338-B1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1569-9293(03)00191-9","article-title":"Towards evidence-based medicine in cardiothoracic surgery: best BETS","volume":"2","author":"Dunning","year":"2003","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2021051021291397500_ivaa338-B2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.athoracsur.2009.09.028","article-title":"Second surgery for recurrence of malignant pleural mesothelioma after extrapleural pneumonectomy","volume":"89","author":"Politi","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"2021051021291397500_ivaa338-B3","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.jtcvs.2013.07.012","article-title":"Clinical indications and results after chest wall resection for recurrent mesothelioma","volume":"146","author":"Burt","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021051021291397500_ivaa338-B4","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1093\/ejcts\/ezv398","article-title":"Relapse pattern and second-line treatment following multimodality treatment for malignant pleural mesothelioma","volume":"49","author":"Kostron","year":"2016","journal-title":"Eur J Cardiothorac Surg"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/32\/5\/761\/37904773\/ivaa338.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/32\/5\/761\/37904773\/ivaa338.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T22:56:53Z","timestamp":1620687413000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/32\/5\/761\/6120245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,26]]},"references-count":4,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,1,26]]},"published-print":{"date-parts":[[2021,5,10]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivaa338","relation":{},"ISSN":["1569-9285"],"issn-type":[{"type":"electronic","value":"1569-9285"}],"subject":[],"published-other":{"date-parts":[[2021,5,1]]},"published":{"date-parts":[[2021,1,26]]}}}