{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:14:34Z","timestamp":1740136474826,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R184-2014-2478"],"award-info":[{"award-number":["R184-2014-2478"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007405","name":"Danish Heart Foundation","doi-asserted-by":"publisher","award":["16-R107-A6588-22041","16-R107-A6588-22042"],"award-info":[{"award-number":["16-R107-A6588-22041","16-R107-A6588-22042"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Graduate School, Health, Aarhus University","award":["18931909"],"award-info":[{"award-number":["18931909"]}]},{"DOI":"10.13039\/501100006308","name":"Helga and Peter Korning Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006308","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2002<\/jats:title>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Entire mitral valve reconstruction with an extracellular matrix tube graft is a potential candidate to overcome the current limitations of mechanical and bioprosthetic valves. However, clinical data have raised concern with respect to patch failure. The aim of our study was to evaluate the impact of extracellular matrix mitral tube graft implantation on mitral annular and subvalvular regional dynamics in pigs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A modified tube graft design made of 2-ply extracellular matrix was used (CorMatrix\u00ae; Cardiovascular Inc., Alpharetta, GA, USA). The reconstructions were performed in an acute 80-kg porcine model (N\u2009=\u20098), where each pig acted as its own control. Haemodynamics were assessed with Mikro-Tip pressure catheters and mitral annular and subvalvular geometry and dynamics with sonomicrometry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Catheter-based peak left atrial pressure and pressure difference across the mitral and aortic valves in the reconstructions were comparable to the values seen in the native mitral valves. Also comparable were maximum mitral annular area (755\u2009\u00b1\u2009100\u2009mm2), maximum septal-lateral distance (29.7\u2009\u00b1\u20091.7\u2009mm), maximum commissure\u2013commissure distance (35.0\u2009\u00b1\u20093.4\u2009mm), end-systolic annular height-to-commissural width ratio (10.2\u2009\u00b1\u20091.0%) and end-diastolic interpapillary muscle distance (27.7\u2009\u00b1\u20093.3\u2009mm). Systolic expansion of the mitral annulus was, however, observed after reconstruction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The reconstructed mitral valves were fully functional without regurgitation, obstruction or stenosis. The reconstructed mitral annular and subvalvular geometry and subvalvular dynamics were found in the same range to those in the native mitral valve. A regional annular ballooning effect occurred that might predispose to patch failure. However, the greatest risk was found at the papillary muscle attachments.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivab027","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T12:14:05Z","timestamp":1610712845000},"page":"978-987","source":"Crossref","is-referenced-by-count":1,"title":["Annular and subvalvular dynamics after extracellular matrix mitral tube graft implantation in pigs"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4772-4319","authenticated-orcid":false,"given":"Marcell J","family":"Tj\u00f8rnild","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Orthopaedic Surgery, Randers Regional Hospital, 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Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Sharghbin","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila L","family":"Benhassen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana M","family":"R\u00f8pcke","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, 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