{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:21:00Z","timestamp":1793805660691,"version":"4.6.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19he1302009"],"award-info":[{"award-number":["JP19he1302009"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Many surgical materials promoting tissue regeneration have been explored for use in paediatric cardiac surgery. The aim of this study is to evaluate the long-term viability and extensibility of the canine aortic wall regenerated using a novel synthetic hybrid fabric.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>The sheet is a warp-knitted fabric of biodegradable (poly-l-lactic acid) and non-biodegradable (polyethylene terephthalate) yarns coated with cross-linked gelatine. This material was implanted as a patch to fill an oval-shaped defect created in the canine descending aorta. The tissue samples were explanted after 12, 24 or 36\u2009months (N\u2009=\u20093, 2, 2, respectively) for histological examination and biomechanical testing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>There was no shrinkage, rupture or aneurysmal change after 24\u2009months. The regenerated wall showed prototypical vascular healing without material degeneration, chronic inflammation, calcification or abnormal intimal overgrowth. Bridging tissue across the patch was well-formed and had expanded over time. The biodegradable yarns had completely degraded at 24\u2009months after implantation, as scheduled, but the regenerated aortic wall demonstrated satisfactory levels of mechanical strength and extensibility in tensile strength tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The sheet achieved good long-term viability and extensibility in the regenerated aortic wall. These findings suggest that it is a promising surgical material for repairing congenital heart defects. Further developments of the sheet are required, including clinical studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivab064","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T21:59:44Z","timestamp":1618351184000},"page":"165-172","source":"Crossref","is-referenced-by-count":6,"title":["Long-term viability and extensibility of an <i>in situ<\/i> regenerated canine aortic wall using hybrid warp-knitted fabric"],"prefix":"10.1093","volume":"33","author":[{"given":"Shintaro","family":"Nemoto","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0967-1201","authenticated-orcid":false,"given":"Takahiro","family":"Katsumata","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Osawa","sequence":"additional","affiliation":[{"name":"Toxicology Research Department, Teijin Institute for Bio-Medical Research, Teijin Pharma Limited, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayuko","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Healthcare Business Development-Medical Device, Teijin Limited, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"2022030915262801500_ivab064-B1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.8493529","article-title":"Tissue engineering","volume":"260","author":"Langer","year":"1993","journal-title":"Science"},{"key":"2022030915262801500_ivab064-B2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jtcvs.2009.09.057","article-title":"Late-term results of tissue-engineered vascular grafts in humans","volume":"139","author":"Hibino","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022030915262801500_ivab064-B3","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.athoracsur.2016.06.095","article-title":"First successful clinical application of the in vivo tissue-engineered autologous vascular graft","volume":"102","author":"Kato","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"2022030915262801500_ivab064-B4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.biomaterials.2017.02.007","article-title":"In situ heart valve tissue engineering using a bioresorbable elastometric implant-From material design to 12 months follow-up in sheep","volume":"125","author":"Kluin","year":"2017","journal-title":"Biomaterials"},{"key":"2022030915262801500_ivab064-B5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11936-017-0566-y","article-title":"Current challenges in translating tissue-engineered heart valves","volume":"19","author":"Stassen","year":"2017","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"2022030915262801500_ivab064-B6","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jtcvs.2016.11.071","article-title":"Total cavopulmonary connection with a new bioabsorbable vascular graft: first clinical experience","volume":"153","author":"Bockeria","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022030915262801500_ivab064-B7","year":"2020"},{"key":"2022030915262801500_ivab064-B8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/ejcts\/ezy045","article-title":"In situ tissue regeneration using a warp-knitted fabric in the canine aorta and inferior vena cava","volume":"54","author":"Nemoto","year":"2018","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022030915262801500_ivab064-B9","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1161\/CIRCULATIONAHA.109.921528","article-title":"Intracoronary optical coherence tomography and histology at 1 month and 2, 3, and 4 years after implantation of everolimus-eluting bioresorbable vascular scaffolds in a porcine coronary artery model: an attempt to decipher the human optical coherence tomography images in the ABSORB trial","volume":"122","author":"Onuma","year":"2010","journal-title":"Circulation"},{"key":"2022030915262801500_ivab064-B10","volume-title":"ISO 7198:2016. Cardiovascular Implants and Extracorporeal Systems\u2014Vascular Prostheses\u2014Tubular Vascular Grafts and Vascular Patches","year":"2016"},{"key":"2022030915262801500_ivab064-B11","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1089\/ten.2006.12.3075","article-title":"Evaluation of tissue-engineered vascular autografts","volume":"12","author":"Matsumura","year":"2006","journal-title":"Tissue Eng"},{"key":"2022030915262801500_ivab064-B12","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1161\/01.RES.10.5.778","article-title":"Relation between pressure and diameter in the ascending aorta of man","volume":"10","author":"Greenfield","year":"1962","journal-title":"Circ Res"},{"key":"2022030915262801500_ivab064-B13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jmbbm.2008.05.002","article-title":"Adaptation and remodeling of vascular wall; biomechanical response to hypertension","volume":"2","author":"Hayashi","year":"2009","journal-title":"J Mech Behav Biomed Mater"},{"key":"2022030915262801500_ivab064-B14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.carpath.2018.10.008","article-title":"Morphology and mechanisms of a novel absorbable polymeric conduit in the pulmonary circulation of sheep","volume":"38","author":"Brugmans","year":"2019","journal-title":"Cardiovasc Pathol"},{"key":"2022030915262801500_ivab064-B15","doi-asserted-by":"crossref","first-page":"I159","DOI":"10.1161\/CIRCULATIONAHA.105.001172","article-title":"Functional growth in tissue-engineered living, vascular grafts: follow-up at 100 weeks in a large animal model","volume":"114","author":"Hoerstrup","year":"2006","journal-title":"Circulation"},{"key":"2022030915262801500_ivab064-B16","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/SLA.0b013e318184dcbd","article-title":"Tissue-engineered vascular grafts demonstrate evidence of growth and development when implanted in a juvenile animal model","volume":"248","author":"Brennan","year":"2008","journal-title":"Ann Surg"},{"key":"2022030915262801500_ivab064-B17","year":"2021"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/33\/2\/165\/42781509\/ivab064.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/33\/2\/165\/42781509\/ivab064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T15:54:12Z","timestamp":1646841252000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/33\/2\/165\/6242732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,4,21]]},"published-print":{"date-parts":[[2021,7,26]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivab064","relation":{},"ISSN":["1569-9285"],"issn-type":[{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,8,1]]},"published":{"date-parts":[[2021,4,21]]}}}