{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:18:09Z","timestamp":1767651489704,"version":"3.37.3"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330034","81770476","81970208"],"award-info":[{"award-number":["81330034","81770476","81970208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["20S31901700"],"award-info":[{"award-number":["20S31901700"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["20QA1408900"],"award-info":[{"award-number":["20QA1408900"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2002<\/jats:title>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>We sought to explore the efficacy of the endovascular repair of an ascending aortic aneurysm with aortic and mitral regurgitation by 2 novel valved stents.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We established models of ascending aortic aneurysms combined with aortic and mitral regurgitation in 10 pig hearts, then implanted self-expanding aortic fenestrated and mitral valved stents via the transapical approach. We applied a fluoroscopy-guided in vitro setting to test the approach, then analysed continuous circulating flushing at 37\u00b0C. Finally, we determined operating times, echocardiography and changes of coronary flow as well as fenestration alignment with the coronary ostia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>This approach resulted in a 100% overall technical success rate, excellent handling properties and precise positioning. The time taken to implant the 2 valved stents was 59\u2009\u00b1\u200912\u2009min. Flow of the left and right coronary arteries did not significantly decrease after the stents were implanted (330.4\u2009\u00b1\u200912.06\u2009ml\/min vs 289.4\u2009\u00b1\u20095.29\u2009ml\/min, P\u2009&amp;lt;\u20090.001; 376.8\u2009\u00b1\u200910.5\u2009ml\/min vs 350.0\u2009\u00b1\u200914.5\u2009ml\/min; P\u2009&amp;lt;\u20090.001). We found no obvious regurgitation and perivalvular leakage; nor did the gradients of the aortic and mitral valves as well as of the left ventricular outflow tract increase significantly. The final angiographic examination and profile of the coronary opening confirmed the good position of the valved stents, the exclusion of the aneurysm and the patency of both coronary arteries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>These findings indicate the potential for combined transcatheter aortic root and mitral valve replacement in treating aortic root pathologies. In future, in vivo studies are expected to validate this approach and ascertain its durability.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivab101","type":"journal-article","created":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T19:06:44Z","timestamp":1616958404000},"page":"474-482","source":"Crossref","is-referenced-by-count":2,"title":["Simultaneous transcatheter treatment of ascending aortic aneurysm with aortic and mitral regurgitation: an <i>in vitro<\/i> study"],"prefix":"10.1093","volume":"33","author":[{"given":"Yuxi","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart Valvular Diseases, and Endovascular Diagnosis and Treatment Center for Aortic Dissection, Navy Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7562-776X","authenticated-orcid":false,"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart Valvular Diseases, and Endovascular Diagnosis and Treatment Center for Aortic Dissection, Navy Medical University, Shanghai, China"},{"name":"Department of Cardiovascular Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart Valvular Diseases, and Endovascular Diagnosis and Treatment Center for Aortic Dissection, Navy Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxiang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart Valvular Diseases, and Endovascular Diagnosis and Treatment Center for Aortic Dissection, Navy Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minxin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart Valvular Diseases, and Endovascular Diagnosis and Treatment Center for Aortic Dissection, Navy Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianhao","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart Valvular Diseases, and Endovascular Diagnosis and Treatment Center for Aortic Dissection, Navy Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart Valvular Diseases, and Endovascular Diagnosis and Treatment Center for Aortic Dissection, Navy Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart Valvular Diseases, and Endovascular Diagnosis and Treatment Center for Aortic Dissection, Navy Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxuan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart Valvular Diseases, and Endovascular Diagnosis and Treatment Center for Aortic Dissection, Navy Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart Valvular Diseases, and Endovascular Diagnosis and Treatment Center for Aortic Dissection, Navy Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaiping","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart 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