{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:46:46Z","timestamp":1779270406128,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Both postoperative and spontaneous chylothorax remain therapeutic challenges without recommendations for a standardized treatment approach. Regardless of its aetiology, patients with chylothorax experience prolonged hospitalization and suffer from the associated complications or the invasive therapy administered.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We conducted a retrospective, observational review of adult patients with chylothorax treated between January 2010 and September 2019. The primary end point was successful management with sustained cessation and\/or controlled chylous output. Therapy duration, inpatient stay and the incidence of complications were evaluated as secondary end points.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of the 36 patients included (22 men; median age 63\u2009years), 24 patients (67%) suffered from a postoperative accumulation of chylous fluid in the pleural space; in the remaining 12 (33%) patients, chylothoraces occurred spontaneously. Initial conservative treatment was successful in 42% (n\u2009=\u200915); in the other 20 cases (56%) additional invasive therapeutic strategies were followed. A complicated course requiring more than 1 treatment was seen in 54% (n\u2009=\u200913) of the postoperative and in 58% (n\u2009=\u20097) of the spontaneous cases. The median length of hospitalization was significantly longer in the postoperative group (37.5 vs 15.5\u2009days; P\u2009=\u20090.016). Serious complications were observed only in the postoperative group (P\u2009=\u20090.28). There were no in-hospital deaths.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Basic treatment of both postoperative and spontaneous chylothorax should include dietary measures in all patients. Additional sclerosing radiotherapy and interventional or surgical therapy are often necessary. The choice of therapeutic approach should be indicated, depending on the aetiology and development of the chylothorax. Early, multimodal treatment is recommended.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivab127","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T21:24:44Z","timestamp":1618867484000},"page":"527-533","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of treatment options for postoperative and spontaneous chylothorax in adults"],"prefix":"10.1093","volume":"33","author":[{"given":"Sigrid","family":"Wiesner","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, University Medical Center Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Loch","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Medical Center Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wibke","family":"Uller","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"G\u00f6\u00dfmann","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiner","family":"Neu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Medical Center Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Stefan","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Medical Center Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Ried","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Medical Center Regensburg, Regensburg, 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