{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:42:14Z","timestamp":1789425734330,"version":"build-2803163510"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T00:00:00Z","timestamp":1623542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,29]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was \u2018For the [cold static storage of donor hearts] does the [cardiac preservation solution] impact on [heart transplant survival]?\u2019. Altogether 182 papers were found using the reported search, of which 9 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. A wide variety of both custom and standardized cardiac preservation solutions are used for the procurement and cold static storage of donor hearts. In heart transplants with shorter cold ischaemic times, survival outcomes appear similar across many of the common cardiac preservation solutions in the long term. However, unspecified cardioplegia (with supraphysiological potassium concentration) is not supported as the final storage solution as it was associated with worse outcomes overall. In the short term, intracellular solutions (&amp;lt;70 mEq\/l sodium; including University of Wisconsin solution) may also have better survival outcomes than extracellular solutions. Where extended ischaemic times (&amp;gt;4\u2009h) are necessary or high-risk grafts obtained, the evidence supports University of Wisconsin as the preferred solution. We concluded that choice of cardiac preservation solution could impact both survival and secondary outcomes.<\/jats:p>","DOI":"10.1093\/icvts\/ivab164","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T11:54:05Z","timestamp":1620647645000},"page":"814-818","source":"Crossref","is-referenced-by-count":9,"title":["Does the solution used for cold static storage of hearts impact on heart transplant survival?"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7252-7053","authenticated-orcid":false,"given":"Adrian","family":"Pannekoek","sequence":"first","affiliation":[{"name":"Department of Clinical Services, Fiona Stanley Hospital, Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umar","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Clinical Services, Fiona Stanley Hospital, Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,13]]},"reference":[{"key":"2022030915261603100_ivab164-B1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1569-9293(03)00191-9","article-title":"Towards evidence-based medicine in cardiothoracic surgery: best BETS","volume":"2","author":"Dunning","year":"2003","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2022030915261603100_ivab164-B2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jss.2019.04.041","article-title":"The effect of cardiac preservation solutions on heart transplant survival","volume":"242","author":"Carter","year":"2019","journal-title":"J Surg Res"},{"key":"2022030915261603100_ivab164-B3","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.transproceed.2013.11.056","article-title":"Myocardial protection in donor heart preservation: a comparison between Bretschneider's histidine\u2013tryptophan\u2013ketoglutarate solution and cold blood cardioplegia","volume":"46","author":"Sung","year":"2014","journal-title":"Transplant Proc"},{"key":"2022030915261603100_ivab164-B4","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.healun.2011.05.005","article-title":"Organ storage with University of Wisconsin solution is associated with improved outcomes after orthotopic heart transplantation","volume":"30","author":"George","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"2022030915261603100_ivab164-B5","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/S0003-4975(01)02458-4","article-title":"A multicenter, randomized, controlled trial of Celsior for flush and hypothermic storage of cardiac allografts","volume":"71","author":"Vega","year":"2001","journal-title":"Ann Thorac Surg"},{"issue":"19 Suppl","key":"2022030915261603100_ivab164-B6","first-page":"II157","article-title":"Impact of University of Wisconsin solution on clinical heart transplantation. A comparison with Stanford solution for extended preservation","volume":"98","author":"Stringham","year":"1998","journal-title":"Circulation"},{"key":"2022030915261603100_ivab164-B7","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/00007890-199701270-00015","article-title":"Organ preservation solutions in heart transplantation\u2014patterns of usage and related survival","volume":"63","author":"Demmy","year":"1997","journal-title":"Transplantation"},{"key":"2022030915261603100_ivab164-B8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1432-2277.1994.tb01424.x","article-title":"Comparison of UW versus HTK solution for myocardial protection in heart transplantation","volume":"7","author":"Reichenspurner","year":"1994","journal-title":"Transplant Int"},{"key":"2022030915261603100_ivab164-B9","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0003-4975(93)90019-E","article-title":"University of Wisconsin versus St. Thomas' Hospital solution for human donor heart preservation","volume":"55","author":"Demertzis","year":"1993","journal-title":"Ann Thorac Surg"},{"key":"2022030915261603100_ivab164-B10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0022-5223(19)36854-0","article-title":"Cardiac preservation in patients undergoing transplantation: a clinical trial comparing University of Wisconsin solution and Stanford solution","volume":"102","author":"Stein","year":"1991","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/33\/5\/814\/42781016\/ivab164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/33\/5\/814\/42781016\/ivab164.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T15:52:10Z","timestamp":1646841130000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/33\/5\/814\/6297837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,13]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,6,13]]},"published-print":{"date-parts":[[2021,10,29]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivab164","relation":{},"ISSN":["1569-9285"],"issn-type":[{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,11,1]]},"published":{"date-parts":[[2021,6,13]]}}}