{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:56:14Z","timestamp":1777416974925,"version":"3.51.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>\u2002<\/jats:title><\/jats:sec><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>Videothoracoscopic visualization and\/or palpation of pulmonary nodules may be difficult due to their location, small size or limited solid component. The purpose of this study is to present our experience with computed tomography (CT)-guided preoperative localization of pulmonary nodules by percutaneous marking with radio-labelled iodine-125 seeds.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 34 pulmonary nodules were marked under CT with the placement of 33 radio-labelled iodine-125 seeds in 32 consecutive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>All patients underwent biportal video-assisted thoracic surgery (VATS) and in no case was conversion to thoracotomy necessary. A total of 88.2% of the lung nodules were successfully resected. In the remaining 11.8%, migration of the seed to the pleural cavity occurred, although these nodules were still resected during VATS. Of all the patients with pneumothorax after the marking procedure, only one required chest tube placement (3.1%). No major postoperative complications were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Preoperative marking of pulmonary nodules with I-125 seeds under CT guidance is a feasible and safe technique that allows their intraoperative identification and resection.<\/jats:p><\/jats:sec>","DOI":"10.1093\/icvts\/ivab223","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T19:31:53Z","timestamp":1626809513000},"page":"91-98","source":"Crossref","is-referenced-by-count":6,"title":["Preoperative radio-guided localization of lung nodules with I-125 seeds: experience with 32 patients at a single institution"],"prefix":"10.1093","volume":"34","author":[{"given":"Sara","family":"Fra-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Universitario Ram\u00f3n y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Gorospe-Saras\u00faa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital Universitario Ram\u00f3n y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odile","family":"Ajuria-Illarramendi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hospital Universitario Ram\u00f3n y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Percy Enrique","family":"Serrano-Carvajal","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Universitario Ram\u00f3n y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma Mar\u00eda","family":"Mu\u00f1oz-Molina","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Universitario Ram\u00f3n y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Caba\u00f1ero-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Universitario Ram\u00f3n y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eugenia","family":"Rioja-Martin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hospital Universitario Ram\u00f3n y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00e1s","family":"Moreno-Mata","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Universitario Ram\u00f3n y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0003-4975(95)01014-9","article-title":"Resection of pulmonary nodules using video-assisted thoracic surgery. The Thorax Group","volume":"61","author":"Bernard","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"2023032020063305600_","first-page":"266","article-title":"Ground-glass opacity lung nodules in the era of lung cancer CT screening: radiology, pathology, and clinical management","volume":"30","author":"Pedersen","year":"2016","journal-title":"Oncology (Williston Park)"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1097\/JTO.0b013e31824fe942","article-title":"Lung cancer screening and video-assisted thoracic surgery","volume":"7","author":"Petersen","year":"2012","journal-title":"J Thorac Oncol"},{"key":"2023032020063305600_","first-page":"411","article-title":"Recommendations from the European Society of Thoracic Surgeons (ESTS) regarding computed tomography screening for lung cancer in Europe","volume":"51","author":"Pedersen","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/resp.12607","article-title":"Optimal surgical management of pulmonary metastases: VATS versus thoracotomy","volume":"21","author":"Numan","year":"2016","journal-title":"Respirology"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"S749","DOI":"10.21037\/jtd.2016.09.71","article-title":"Image-guided techniques for localizing pulmonary nodules in thoracoscopic surgery","volume":"8","author":"Lin","year":"2016","journal-title":"J Thorac Dis"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.thorsurg.2015.12.001","article-title":"Advances in image-guided thoracic surgery","volume":"26","author":"Kidane","year":"2016","journal-title":"Thorac Surg Clin"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/j.athoracsur.2015.05.029","article-title":"Clinical analysis of percutaneous computed tomography\u2013guided hook wire localization of 168 small pulmonary nodules","volume":"100","author":"Xu","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.athoracsur.2013.05.026","article-title":"Efficacy and complications of computed tomography-guided hook wire localization","volume":"96","author":"Ichinose","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jtcvs.2014.08.055","article-title":"Preoperative computed tomography-guided microcoil localization of small peripheral pulmonary nodules: a prospective randomized controlled trial","volume":"149","author":"Finley","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1007\/s00330-015-3676-5","article-title":"CT-guided localization of small pulmonary nodules using adjacent microcoil implantation prior to video-assisted thoracoscopic surgical resection","volume":"25","author":"Su","year":"2015","journal-title":"Eur Radiol"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13019-018-0697-6","article-title":"Near-infrared dye marking for thoracoscopic resection of small-sized pulmonary nodules: comparison of percutaneous and bronchoscopic injection techniques","volume":"13","author":"Anayama","year":"2018","journal-title":"J Cardiothorac Surg"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2214\/ajr.163.2.7518642","article-title":"Localization of pulmonary nodules before thoracoscopic surgery: value of percutaneous staining with methylene blue","volume":"163","author":"Lenglinger","year":"1994","journal-title":"AJR Am J Roentgenol"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1010-7940(00)00411-5","article-title":"A pilot study of the role of TC-99 radionuclide in localization of pulmonary nodular lesions for thoracoscopic resection","volume":"18","author":"Chella","year":"2000","journal-title":"Eur J Cardiothorac Surg"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.athoracsur.2010.08.016","article-title":"Computed tomography-guided preoperative radiotracer localization of nonpalpable lung nodules","volume":"90","author":"Bellomi","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.ejso.2013.06.020","article-title":"The use of iodine seed (I-125) as a marker for the localisation of lung nodules in minimal invasive pulmonary surgery","volume":"39","author":"Gobardhan","year":"2013","journal-title":"Eur J Surg Oncol"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.arbr.2018.11.001","article-title":"Percutaneous marking of 2 adjacent pulmonary metastases with a single equidistant seed","volume":"55","author":"Gorospe-Saras\u00faa","year":"2019","journal-title":"Arch Bronconeumol (Engl Ed)"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1378\/chest.115.2.563","article-title":"Video-assisted thoracoscopic surgery for small indeterminate pulmonary nodules: indications for preoperative marking","volume":"115","author":"Suzuki","year":"1999","journal-title":"Chest"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s00464-005-0407-z","article-title":"Intrathoracoscopic localization techniques. Review of literature","volume":"20","author":"Sortini","year":"2006","journal-title":"Surg Endosc"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.athoracsur.2016.09.112","article-title":"Preoperative localization of lung nodules with fiducial markers: feasibility and technical considerations","volume":"103","author":"Sharma","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.jtcvs.2009.02.002","article-title":"Intraoperative ultrasonographic localization of pulmonary ground-glass opacities","volume":"138","author":"Kondo","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/S0003-4975(99)00764-X","article-title":"Fluoroscopy-aided thoracoscopic resection of pulmonary nodule localized with contrast media","volume":"68","author":"Moon","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jtcvs.2006.04.012","article-title":"Usefulness and complications of computed tomography-guided lipiodol marking for fluoroscopy-assisted thoracoscopic resection of small pulmonary nodules: experience with 174 nodules","volume":"132","author":"Watanabe","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/RLU.0000000000001997","article-title":"Clinical impact of radioguided localization in the treatment of solitary pulmonary nodule: a 20-year retrospective analysis","volume":"43","author":"Manca","year":"2018","journal-title":"Clin Nucl Med"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.athoracsur.2003.10.122","article-title":"Video-assisted thoracoscopic surgery for pulmonary nodules after computed tomography-guided marking with a spiral wire","volume":"79","author":"Eichfeld","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brachy.2018.09.003","article-title":"Permanent prostate brachytherapy monotherapy with I-125 for low- and intermediate-risk prostate cancer: outcomes in 974 patients","volume":"18","author":"Routman","year":"2019","journal-title":"Brachytherapy"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0003-4975(02)04098-5","article-title":"Limited resection for non-small cell lung cancer: observed local control with implantation of I-125 brachytherapy seeds","volume":"75","author":"Lee","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.chest.2016.09.017","article-title":"Comparative effectiveness and safety of preoperative lung localization for pulmonary nodules: a systematic review and meta-analysis","volume":"151","author":"Park","year":"2017","journal-title":"Chest"},{"key":"2023032020063305600_","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.breast.2013.04.016","article-title":"Radioactive seed localisation (RSL) in the treatment of non-palpable breast cancers: systematic review and meta-analysis","volume":"22","author":"Ahmed","year":"2013","journal-title":"Breast"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/34\/1\/91\/49571671\/ivab223.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/34\/1\/91\/49571671\/ivab223.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T08:13:54Z","timestamp":1699258434000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/34\/1\/91\/6347640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivab223","relation":{},"ISSN":["1569-9285"],"issn-type":[{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2021,8,11]]}}}