{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T03:44:32Z","timestamp":1770349472050,"version":"3.49.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Health and Medical Research Council Medical Research Postgraduate Scholarship","award":["1150242"],"award-info":[{"award-number":["1150242"]}]},{"name":"National Health and Medical Research Council of Australia","award":["1082186"],"award-info":[{"award-number":["1082186"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Left ventricular outflow tract obstruction (LVOTO) is a recognized complication after complete repair of atrioventricular septal defect (AVSD). This study reviewed the incidence and management of LVOTO following AVSD repair at a single institution.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>From 1975 to 2019, 24 patients (3.3%, 24\/730) underwent reoperation due to LVOTO following partial AVSD (pAVSD) and complete AVSD (cAVSD) repair. The data were retrospectively reviewed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The incidence of LVOTO following pAVSD and cAVSD repair was 4.4% (12\/275) and 2.6% (12\/455). Freedom from LVOTO reoperation following pAVSD and cAVSD repair at 25\u2009years was 94.3% [95% confidence interval (CI); 89.7\u201396.7] and 95% (95% CI; 91.1\u201397.3). The median time from complete repair of pAVSD and cAVSD to LVOTO reoperation was 4.4\u2009years [interquartile range (IQR): 3.4\u20136.7] and 2.6\u2009years (IQR: 2.2\u20134.7). Freedom from second LVOTO reoperation at 5, 10 and 15\u2009years was 83.7% (95% CI; 57.2\u201398.2), 59.2% (95% CI; 28.7, 80.3) and 39.5% (95% CI; 13.2\u201365.3). The median time between the first and the second LVOTO reoperation in the groups of pAVSD and cAVSD was 6.1\u2009years (IQR: 3.4\u20138.9) and 8.6\u2009years (IQR: 5.7\u20139.8). There was no significant difference regarding the first (P\u2009=\u20090.7406) and subsequent LVOTO (P\u2009=\u20090.7153) following complete repair of pAVSD and cAVSD. Combined access to the left ventricular outflow tract was not protective regarding LVOTO reoccurrence. Survival for both groups after LVOTO reoperation at 15\u2009years was 95.6% (95% CI 99.4\u201372.9).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Incidence of LVOTO after AVSD repair is low but the reoccurrence rate is high. Standard subaortic resection does not always provide definitive LVOTO relief. The survival after LVOTO reoperation is excellent.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivab303","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T11:10:14Z","timestamp":1634814614000},"page":"604-610","source":"Crossref","is-referenced-by-count":9,"title":["Incidence and management of the left ventricular outflow obstruction in patients with atrioventricular septal defects"],"prefix":"10.1093","volume":"34","author":[{"given":"Yaroslav","family":"Ivanov","sequence":"first","affiliation":[{"name":"Cardiac Surgery Unit, The Royal Children\u2019s Hospital, Parkville, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8330-3917","authenticated-orcid":false,"given":"Edward","family":"Buratto","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, The Royal Children\u2019s Hospital, Parkville, VIC, Australia"},{"name":"Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia"},{"name":"Murdoch Children\u2019s Research Institute, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Naimo","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, The Royal Children\u2019s Hospital, Parkville, VIC, Australia"},{"name":"Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienne","family":"Lui","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, The Royal Children\u2019s Hospital, Parkville, VIC, Australia"},{"name":"Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0117-5796","authenticated-orcid":false,"given":"Thomas","family":"Hu","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, The Royal Children\u2019s Hospital, Parkville, VIC, Australia"},{"name":"Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-7836","authenticated-orcid":false,"given":"Yves","family":"d\u2019Udekem","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, The Royal Children\u2019s Hospital, Parkville, VIC, Australia"},{"name":"Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia"},{"name":"Murdoch Children\u2019s Research Institute, Melbourne, VIC, Australia"},{"name":"Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian P","family":"Brizard","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, The Royal Children\u2019s Hospital, Parkville, VIC, Australia"},{"name":"Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia"},{"name":"Murdoch Children\u2019s Research Institute, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor E","family":"Konstantinov","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, The Royal Children\u2019s Hospital, Parkville, VIC, Australia"},{"name":"Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia"},{"name":"Murdoch Children\u2019s Research Institute, Melbourne, VIC, Australia"},{"name":"Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"2022040109592003000_ivab303-B1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/ejcts\/ezu286","article-title":"Repair of partial atrioventricular septal defect: a 37-year 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