{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:55:46Z","timestamp":1772254546013,"version":"3.50.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2002<\/jats:title>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>To evaluate in-hospital outcomes of concomitant mitral valve replacement (MVR) in patients undergoing conventional aortic valve replacement due to aortic stenosis in a nationwide cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Administrative data from all patients with aortic stenosis undergoing conventional aortic and concomitant MVR (reason for MVR not specified) between 2017 and 2018 in Germany were analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 2597 patients with a preoperative logistic EuroScore of 9.81 (standard deviation: 8.56) were identified. In-hospital mortality was 6.8%. An in-hospital stroke occurred in 3.4%, acute kidney injury in 16.3%, prolonged mechanical ventilation of more than 48\u2009h in 16.3%, postoperative delirium in 15.8% and postoperative pacemaker implantation in 7.6% of the patients. Mean hospital stay was 16.5 (standard deviation: 12.1) days. Age [odds ratio (OR): 1.03; P\u2009=\u20090.019], New York Heart Association class III or IV (OR: 1.63; P\u2009=\u20090.012), previous cardiac surgery (OR: 2.85, P\u2009=\u20090.002), peripheral vascular disease (OR: 2.01, P\u2009=\u20090.031), pulmonary hypertension (OR: 1.63, P\u2009=\u20090.042) and impaired renal function (glomerular filtration rate &amp;lt;15, OR: 3.58, P\u2009=\u20090.001; glomerular filtration rate &amp;lt;30, OR: 2.51, P\u2009=\u20090.037) were identified as independent predictors for in-hospital mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In this nationwide analysis, concomitant aortic and MVR was associated with acceptable in-hospital mortality, morbidity and length of in-hospital stay. The regression analyses may help to identify high-risk patients and further optimize treatment strategies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivab352","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T20:19:19Z","timestamp":1638389959000},"page":"349-353","source":"Crossref","is-referenced-by-count":8,"title":["In-hospital outcomes of patients undergoing concomitant aortic and mitral valve replacement in Germany"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3099-7254","authenticated-orcid":false,"given":"Maximilian","family":"Kreibich","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart Center Freiburg, Freiburg, Germany"},{"name":"Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-6945","authenticated-orcid":false,"given":"Klaus","family":"Kaier","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Freiburg, Freiburg, Germany"},{"name":"Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"von zur M\u00fchlen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Freiburg, Freiburg, Germany"},{"name":"Departments of Cardiology and Angiology I, University Heart Center Freiburg, Freiburg, Germany"},{"name":"Department of Cardiology and Angiology I, Faculty of Medicine, Center of Big Data Analysis in Cardiology (CeBAC), Heart Center Freiburg University, University of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3305-9343","authenticated-orcid":false,"given":"Matthias","family":"Siepe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart Center Freiburg, Freiburg, Germany"},{"name":"Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Zehender","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Freiburg, Freiburg, Germany"},{"name":"Departments of Cardiology and Angiology I, University Heart Center Freiburg, Freiburg, Germany"},{"name":"Department of Cardiology and Angiology I, Faculty of Medicine, Center of Big Data Analysis in Cardiology (CeBAC), Heart Center Freiburg University, University of Freiburg, Freiburg, 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