{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:23:43Z","timestamp":1784827423280,"version":"3.55.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Donald J. Ferguson, MD, Surgical Research Fund at the University of Chicago"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Thoracic sympathectomy has been shown to be effective in reducing implantable cardioverter-defibrillator (ICD) shocks and ventricular tachycardia recurrence in patients with channelopathies, but the evidence supporting its use for refractory ventricular arrhythmias in patients without channelopathies is limited. This is a single-centre cohort study of bilateral R1\u2013R4 thoracoscopic sympathectomy for medically refractory ventricular arrhythmias.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Clinical information was examined for all bilateral thoracoscopic R1\u2013R4 sympathectomies for ventricular arrhythmias at our institution from 2016 through 2020.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Thirteen patients underwent bilateral thoracoscopic R1\u2013R4 sympathectomy. All patients had prior ICD implant. Patients had a recent history of multiple ICD discharges (12\/13), catheter ablation (10\/13) and cardiac arrest (3\/13). Ten patients were urgently operated on following transfer to our centre for sustained ventricular tachycardia. Seven patients had ventricular tachycardia ablations preoperatively during the same admission. Five patients were in intensive care immediately preoperatively, with 3 requiring mechanical ventilation. Three patients suffered in-hospital mortality. Kaplan\u2013Meier analysis estimated 73% overall survival at 24-month follow-up. Among the 10 patients who survived to discharge, all were alive at a median follow-up of 8.7\u2009months (interquartile range 0.6\u201326.7\u2009months). Six of 10 patients had no further ICD discharges. Kaplan\u2013Meier analysis estimated 27% ICD shock-free survival at 24\u2009months follow-up for all patients. Three of 10 patients had additional ablations, while 2 patients underwent cardiac transplantation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Bilateral thoracoscopic sympathectomy is an effective option for patients with life-threatening ventricular arrhythmia refractory to pharmacotherapy and catheter ablation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivab372","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T12:23:07Z","timestamp":1640175787000},"page":"783-790","source":"Crossref","is-referenced-by-count":11,"title":["Thoracoscopic sympathectomy decreases disease burden in patients with medically refractory ventricular arrhythmias"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-7886","authenticated-orcid":false,"given":"Andy Chao Hsuan","family":"Lee","sequence":"first","affiliation":[{"name":"Section of Thoracic Surgery, Department of Surgery, The University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8513-1303","authenticated-orcid":false,"given":"Roderick","family":"Tung","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, University of Arizona, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-7668","authenticated-orcid":false,"given":"Mark K","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Section of Thoracic Surgery, Department of Surgery, The University of Chicago, Chicago, IL, 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