{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:43:25Z","timestamp":1756896205719,"version":"3.37.3"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH","doi-asserted-by":"crossref","award":["R01 HL152155","NIH R01 HL089315-01"],"award-info":[{"award-number":["R01 HL152155","NIH R01 HL089315-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Thoracic Surgery Foundation Resident Research Fellowship"},{"name":"National Science Foundation Graduate Research Fellowship Program","award":["DGE-1656518"],"award-info":[{"award-number":["DGE-1656518"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p\/><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>The severity of acute papillary muscle (PM) rupture varies according to the extent and site of the rupture. However, the haemodynamic effects of different rupture variations are still poorly understood. Using a novel ex vivo model, we sought to study acute PM rupture to improve clinical management.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Using porcine mitral valves (n\u2009=\u200932) mounted within an ex vivo left heart simulator, PM rupture was simulated. The mitral valve was divided into quadrants for analysis according to the PM heads. Acute PM rupture was simulated by incrementally cutting from 1\/3 to the total number of chordae arising from 1 PM head of interest. Haemodynamic parameters were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Rupture &amp;gt;2\/3 of the chordae from 1 given PM head or regurgitation fraction &amp;gt;60% led to markedly deteriorated haemodynamics. Rupture at the anterolateral PM had a stronger negative effect on haemodynamics than rupture at the posteromedial PM. Rupture occurring at the anterior head of the anterolateral PM led to more marked haemodynamic instability than rupture occurring at the other PM heads.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The haemodynamic effects of acute PM rupture vary considerably according to the site and extent of the rupture. Rupture of \u22642\/3 of chordae from 1 PM head or rupture at the posteromedial PM lead to less marked haemodynamics effects, suggesting a higher likelihood of tolerating surgery. Rupture at the anterolateral PM, specifically the anterior head, rupture of &amp;gt;2\/3 of chordae from 1 PM head or regurgitation fraction &amp;gt;60% led to marked haemodynamic instability, suggesting the potential benefit from bridging strategies prior to surgery.<\/jats:p><\/jats:sec>","DOI":"10.1093\/icvts\/ivab373","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T20:11:52Z","timestamp":1639685512000},"page":"822-830","source":"Crossref","is-referenced-by-count":4,"title":["Biomechanical engineering analysis of an acute papillary muscle rupture disease model using an innovative 3D-printed left heart simulator"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1000-4710","authenticated-orcid":false,"given":"Mateo","family":"Marin-Cuartas","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA"},{"name":"University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5642-9883","authenticated-orcid":false,"given":"Yuanjia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA"},{"name":"Department of Bioengineering, Stanford University, Stanford, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabel M","family":"Imbrie-Moore","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA"},{"name":"Department of Mechanical Engineering, Stanford University, Stanford, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew H","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA"},{"name":"Department of Mechanical Engineering, Stanford 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