{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:49:55Z","timestamp":1771300195324,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The aim of this study was to review a single institution\u2019s experience with EXCOR Paediatric implantation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Patients &amp;lt;15\u2009years old who underwent EXCOR implantation as a bridge to transplantation between 2015 and 2021 were enrolled. Major adverse events included death, cerebrovascular event resulting in sequelae, major infection (sepsis or surgical site infection requiring open sternal irrigation or device removal) and device malfunction requiring surgical treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Overall median age and weight for all 20 children at implantation were 10.8 (interquartile range, 7.9\u201333.2) months and 6.3 (4.6\u201310.2) kg. Ten patients (50%) weighed &amp;lt;5\u2009kg. Primary diagnoses were dilated cardiomyopathy in 13 patients, fulminant myocarditis in 3, restrictive cardiomyopathy in 2 and congenital heart disease in 2. Two patients required biventricular assist support. The median support time was 365 (241\u2013636) days. Six patients (30%) were supported for &amp;gt;20\u2009months. One patient died. Seven patients underwent heart transplant. Heart transplant has not been performed in the last 1.5\u2009years. Five patients were weaned from EXCOR support after native myocardial recovery, including a patient with dilated cardiomyopathy who recovered after 24\u2009months of EXCOR support. Major complication-free survival at 6, 12 and 18\u2009months were 79.3%, 49.6% and 38.6%, respectively. Body weight &amp;lt;5\u2009kg at implantation was a risk factor for decreased major complication-free survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Survival during EXCOR Paediatric support was good, but it prolonged the wait time for a heart transplant. The number of major complications increased over time and was not negligible, especially in small children.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivac051","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T12:08:22Z","timestamp":1645272502000},"source":"Crossref","is-referenced-by-count":4,"title":["Short-term outcomes of EXCOR Paediatric implantation"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8321-7277","authenticated-orcid":false,"given":"Motoki","family":"Komori","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0320-3682","authenticated-orcid":false,"given":"Takaya","family":"Hoashi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heima","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Okuda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1367-4066","authenticated-orcid":false,"given":"Norihide","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Pediatric Transplantation, National Cerebral and Cardiovascular Center , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"2022070412562632200_ivac051-B1","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1253\/circj.CJ-16-0819","article-title":"Early single institutional experience of Berlin Heart EXCOR\u00ae pediatric ventricular assist device in Japan","volume":"80","author":"Kakuta","year":"2016","journal-title":"Circ J"},{"key":"2022070412562632200_ivac051-B2","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1056\/NEJMoa1014164","article-title":"Prospective trial of a pediatric ventricular assist device","volume":"367","author":"Fraser","year":"2012","journal-title":"N Engl J Med"},{"key":"2022070412562632200_ivac051-B3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/0391398818773040","article-title":"Antithrombotic therapy in pediatric ventricular assist devices: multicenter survey of the European EXCOR Pediatric Investigator Group","volume":"41","author":"Miera","year":"2018","journal-title":"Int J Artif Organs"},{"key":"2022070412562632200_ivac051-B4","doi-asserted-by":"crossref","first-page":"e13181","DOI":"10.1111\/petr.13181","article-title":"Characteristics of deposits and pump exchange in the Berlin Heart EXCOR ventricular assist device: experience with 67 cases","volume":"22","author":"Maeda","year":"2018","journal-title":"Pediatr Transplant"},{"key":"2022070412562632200_ivac051-B5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s41038-018-0135-y","article-title":"Prospective randomised controlled trial of Algisite\u2122 M, Cuticerin\u2122, and Sorbact\u00ae as donor site dressings in paediatric split-thickness skin grafts","volume":"6","author":"McBride","year":"2018","journal-title":"Burns Trauma"},{"key":"2022070412562632200_ivac051-B6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.12968\/jowc.2016.25.2.76","article-title":"Binding of two bacterial biofilms to dialkyl carbamoyl chloride (DACC)-coated dressings in vitro","volume":"25","author":"Cooper","year":"2016","journal-title":"J Wound Care"},{"key":"2022070412562632200_ivac051-B7","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/eurheartj\/ehq353","article-title":"Heart failure reversal by ventricular unloading in patients with chronic cardiomyopathy: criteria for weaning from ventricular assist devices","volume":"32","author":"Dandel","year":"2011","journal-title":"Eur Heart J"},{"key":"2022070412562632200_ivac051-B8","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/ejcts\/ezaa409","article-title":"Interventricular septal haematoma after EXCOR paediatric implantation","volume":"59","author":"Komori","year":"2021","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022070412562632200_ivac051-B9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.9794\/jspccs.33.10","article-title":"Current status and issues of pediatric heart transplantation in Japan","volume":"2017","author":"Fukushima","year":"2017","journal-title":"Ped Cardiol Card Surg"},{"key":"2022070412562632200_ivac051-B10","doi-asserted-by":"crossref","first-page":"e709","DOI":"10.1016\/S2468-2667(21)00200-0","article-title":"COVID-19 pandemic and worldwide organ transplantation: a population-based study","volume":"6","author":"Aubert","year":"2021","journal-title":"Lancet Public Health"},{"key":"2022070412562632200_ivac051-B11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/ejcts\/ezw011","article-title":"Paediatric mechanical circulatory support with Berlin Heart EXCOR: development and outcome of a 23-year experience","volume":"50","author":"Hetzer","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022070412562632200_ivac051-B12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5603\/KP.a2017.0201","article-title":"First Polish analysis of the treatment of advanced heart failure in children with the use of Berlin Heart EXCOR mechanical circulatory support","volume":"76","author":"Pawlak","year":"2018","journal-title":"Kardiol Pol"},{"key":"2022070412562632200_ivac051-B13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/aor.12552","article-title":"Long-term mechanical circulatory support in pediatric patients","volume":"40","author":"Sandica","year":"2016","journal-title":"Artif Organs"},{"key":"2022070412562632200_ivac051-B14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/ejcts\/ezaa033","article-title":"Bridge to recovery with Berlin Heart EXCOR in children &lt;10\u2009kg with dilated cardiomyopathy: a histological analysis","volume":"58","author":"Tominaga","year":"2020","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022070412562632200_ivac051-B15","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/ejcts\/ezy394","article-title":"Improvement of survival in low-weight children on the Berlin Heart EXCOR ventricular assist device support","volume":"55","author":"Miera","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022070412562632200_ivac051-B16","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1093\/ejcts\/ezaa132","article-title":"The European registry for patients with mechanical circulatory support (EUROMACS): second EUROMACS paediatric (Paedi-EUROMACS) report","volume":"57","author":"de By","year":"2020","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022070412562632200_ivac051-B17","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.hlc.2020.05.104","article-title":"Berlin Heart EXCOR support in the first year of life: a single centre experience","volume":"30","author":"Davis","year":"2021","journal-title":"Heart Lung Circ"},{"key":"2022070412562632200_ivac051-B18","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.athoracsur.2019.01.038","article-title":"Third annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) report: preimplant characteristics and outcomes","volume":"107","author":"Morales","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"2022070412562632200_ivac051-B19","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.recesp.2016.01.022","article-title":"Two different sites of membrane rupture in the Berlin-Heart EXCOR ventricular assist device","volume":"69","author":"Sousa Casasnovas","year":"2016","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"2022070412562632200_ivac051-B20","doi-asserted-by":"crossref","first-page":"e129-30","DOI":"10.1016\/j.athoracsur.2016.01.022","article-title":"Berlin Heart EXCOR ventricular assist device: multilayer membrane rupture in a pediatric patient","volume":"102","author":"Di Molfetta","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"2022070412562632200_ivac051-B21","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.healun.2014.03.007","article-title":"Pump size of Berlin Heart EXCOR pediatric device influences clinical outcome in children","volume":"33","author":"Miera","year":"2014","journal-title":"J Heart Lung Transplant"},{"key":"2022070412562632200_ivac051-B22","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jtcvs.2005.05.016","article-title":"Who would be a candidate for bridge to recovery during prolonged mechanical left ventricular support in idiopathic dilated cardiomyopathy?","volume":"130","author":"Matsumiya","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022070412562632200_ivac051-B23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.xjtc.2021.02.023","article-title":"Ventricular assist device-promoted recovery and technical aspects of explant","volume":"7","author":"Faerber","year":"2021","journal-title":"JTCVS Tech"},{"key":"2022070412562632200_ivac051-B24","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.healun.2018.08.005","article-title":"Bridge to recovery in children on ventricular assist devices-protocol, predictors of recovery, and long-term follow-up","volume":"37","author":"Miera","year":"2018","journal-title":"J Heart Lung Transplant"},{"key":"2022070412562632200_ivac051-B25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00595-015-1149-8","article-title":"Building a bridge to recovery: the pathophysiology of LVAD-induced reverse modeling in heart failure","volume":"46","author":"Miyagawa","year":"2016","journal-title":"Surg Today"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/35\/1\/ivac051\/44394755\/ivac051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/35\/1\/ivac051\/44394755\/ivac051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T12:56:54Z","timestamp":1656939414000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivac051\/6545045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,6,15]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivac051","relation":{},"ISSN":["1569-9293","1569-9285"],"issn-type":[{"value":"1569-9293","type":"print"},{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,3,9]]},"article-number":"ivac051"}}