{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T01:51:12Z","timestamp":1793670672164,"version":"4.5.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Transapical Neochordae implantation (NC) allows beating heart mitral valve repair in patients with degenerative mitral regurgitation. The aim of this single-centre, retrospective study was to compare outcomes of NC versus conventional surgical (CS) mitral valve repair.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Data of patients who underwent isolated mitral valve repair with NC or CS from January 2010 to December 2018 were collected. A propensity score matching analysis was performed to reduce confounding due to baseline differences between groups. The primary end point was overall all-cause mortality; secondary end points were freedom from reoperation, freedom from moderate (2+) and from severe (3+) mitral regurgitation (MR) and New York Heart Association functional class in the overall population and in patients with isolated P2 prolapse (type A anatomy).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Propensity analysis selected 88 matched pairs. There was no 30-day mortality in the 2 groups. Kaplan\u2013Meier analysis showed similar 5-year survival in the 2 groups. Patients undergoing NC showed worse freedom from moderate MR (\u22652+) (57.6% vs 84.6%; P &amp;lt; 0.001) and from severe MR (3+) at 5-year follow-up: 78.1% vs 89.7% (P = 0.032). In patients with type A anatomy, freedom from moderate MR and from severe MR was similar between groups (moderate: 63.9% vs 74.6%; P = 0.21; severe: 79.3% vs 79%; P = 0.77 in NC and FS, respectively). Freedom from reoperation was lower in the NC group: 78.9% vs 92% (P = 0.022) but, in type A patients, it was similar: 79.7% and 85% (P = 0.75) in the NC and CS group, respectively. More than 90% of patients of both groups were in New York Heart Association class I and II at follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Transapical beating-heart mitral chordae implantation can be considered as an alternative treatment to CS, especially in patients with isolated P2 prolapse<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivac053","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T12:08:08Z","timestamp":1645877288000},"source":"Crossref","is-referenced-by-count":20,"title":["Transapical beating heart mitral valve repair versus conventional surgery: a propensity-matched study"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9835-9091","authenticated-orcid":false,"given":"A","family":"D\u2019Onofrio","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9559-1565","authenticated-orcid":false,"given":"F","family":"Mastro","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6758-5232","authenticated-orcid":false,"given":"M","family":"Nadali","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4029-5678","authenticated-orcid":false,"given":"A","family":"Fiocco","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Pittarello","sequence":"additional","affiliation":[{"name":"Division of Anesthesiology, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Aruta","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Echo Lab, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Lorenzoni","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-0580","authenticated-orcid":false,"given":"D","family":"Gregori","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-699X","authenticated-orcid":false,"given":"G","family":"Gerosa","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"2022070412563710100_ivac053-B1","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"key":"2022070412563710100_ivac053-B2","article-title":"2020 ACC\/AHA Guideline for the management of patients with valvular heart disease","author":"Otto","journal-title":"J Am Coll Cardiol"},{"key":"2022070412563710100_ivac053-B3","first-page":"230","article-title":"Mitral valve repair versus replacement","volume":"4","author":"Mick","year":"2015","journal-title":"Ann Cardiothorac Surg"},{"key":"2022070412563710100_ivac053-B4","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1161\/CIRCULATIONAHA.116.023340","article-title":"Twenty-year outcome after mitral repair versus replacement for severe degenerative mitral regurgitation. 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